The role of S100 genes in breast cancer progression.

Hdl Handle:
http://hdl.handle.net/10147/207493
Title:
The role of S100 genes in breast cancer progression.
Authors:
McKiernan, Eadaoin; McDermott, Enda W; Evoy, Dennis; Crown, John; Duffy, Michael J
Affiliation:
Department of Pathology and Laboratory Medicine, St Vincent's University, Hospital, Dublin 4, Ireland. eadaoin0@yahoo.com
Citation:
Tumour Biol. 2011 Jun;32(3):441-50. Epub 2010 Dec 14.
Journal:
Tumour biology : the journal of the International Society for Oncodevelopmental, Biology and Medicine
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207493
DOI:
10.1007/s13277-010-0137-2
PubMed ID:
21153724
Abstract:
The S100 gene family encode low molecular weight proteins implicated in cancer progression. In this study, we analyzed the expression of four S100 genes in one cohort of patients with breast cancer and 16 S100 genes in a second cohort. In both cohorts, the expression of S100A8 and S1009 mRNA level was elevated in high-grade compared to low-grade tumors and in estrogen receptor-negative compared to estrogen receptor-positive tumors. None of the S100 transcripts investigated were significantly associated with the presence of lymph node metastasis. Notably, multiple S100 genes, including S100A1, S100A2, S100A4, S100A6, S100A8, S100A9, S100A10, S100A11, and S100A14 were upregulated in basal-type breast cancers compared to non-basal types. Using Spearman's correlation analysis, several S100 transcripts correlated significantly with each other, the strongest correlation has been found between S100A8 and S100A9 (r = 0.889, P < 0.001, n = 295). Of the 16 S100 transcripts investigated, only S100A11 and S100A14 were significantly associated with patient outcome. Indeed, these two transcripts predicted outcome in the cohort of patients that did not receive systemic adjuvant therapy. Based on our findings, we conclude that the different S100 genes play varying roles in breast cancer progression. Specific S100 genes are potential targets for the treatment of basal-type breast cancers.
Language:
eng
MeSH:
Adult; Aged; Breast Neoplasms/*etiology; Cohort Studies; Disease Progression; Female; Humans; Middle Aged; RNA, Messenger/analysis; S100 Proteins/*genetics/physiology
ISSN:
1423-0380 (Electronic); 1010-4283 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcKiernan, Eadaoinen_GB
dc.contributor.authorMcDermott, Enda Wen_GB
dc.contributor.authorEvoy, Dennisen_GB
dc.contributor.authorCrown, Johnen_GB
dc.contributor.authorDuffy, Michael Jen_GB
dc.date.accessioned2012-02-01T10:29:24Z-
dc.date.available2012-02-01T10:29:24Z-
dc.date.issued2012-02-01T10:29:24Z-
dc.identifier.citationTumour Biol. 2011 Jun;32(3):441-50. Epub 2010 Dec 14.en_GB
dc.identifier.issn1423-0380 (Electronic)en_GB
dc.identifier.issn1010-4283 (Linking)en_GB
dc.identifier.pmid21153724en_GB
dc.identifier.doi10.1007/s13277-010-0137-2en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207493-
dc.description.abstractThe S100 gene family encode low molecular weight proteins implicated in cancer progression. In this study, we analyzed the expression of four S100 genes in one cohort of patients with breast cancer and 16 S100 genes in a second cohort. In both cohorts, the expression of S100A8 and S1009 mRNA level was elevated in high-grade compared to low-grade tumors and in estrogen receptor-negative compared to estrogen receptor-positive tumors. None of the S100 transcripts investigated were significantly associated with the presence of lymph node metastasis. Notably, multiple S100 genes, including S100A1, S100A2, S100A4, S100A6, S100A8, S100A9, S100A10, S100A11, and S100A14 were upregulated in basal-type breast cancers compared to non-basal types. Using Spearman's correlation analysis, several S100 transcripts correlated significantly with each other, the strongest correlation has been found between S100A8 and S100A9 (r = 0.889, P < 0.001, n = 295). Of the 16 S100 transcripts investigated, only S100A11 and S100A14 were significantly associated with patient outcome. Indeed, these two transcripts predicted outcome in the cohort of patients that did not receive systemic adjuvant therapy. Based on our findings, we conclude that the different S100 genes play varying roles in breast cancer progression. Specific S100 genes are potential targets for the treatment of basal-type breast cancers.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshBreast Neoplasms/*etiologyen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshDisease Progressionen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRNA, Messenger/analysisen_GB
dc.subject.meshS100 Proteins/*genetics/physiologyen_GB
dc.titleThe role of S100 genes in breast cancer progression.en_GB
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, St Vincent's University, Hospital, Dublin 4, Ireland. eadaoin0@yahoo.comen_GB
dc.identifier.journalTumour biology : the journal of the International Society for Oncodevelopmental, Biology and Medicineen_GB
dc.description.provinceLeinster-

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