Affiliation
Department of Dermatology, St Vincent's University Hospital, Dublin, Ireland., tobin.annemarie@gmail.comIssue Date
2012-02-01T10:29:11ZMeSH
HumansImmunity, Innate
Killer Cells, Natural/*immunology
Psoriasis/*immunology/pathology/*physiopathology
Skin/immunology/pathology
Metadata
Show full item recordCitation
J Innate Immun. 2011;3(4):403-10. Epub 2011 May 25.Journal
Journal of innate immunityDOI
10.1159/000328011PubMed ID
21613780Abstract
Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-alpha, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions, natural killer and natural killer T cells appear to have a unique role. We review the evidence supporting a role for natural killer cells in psoriasis.Language
engISSN
1662-8128 (Electronic)1662-811X (Linking)
ae974a485f413a2113503eed53cd6c53
10.1159/000328011