Estrogen and its role in gastrointestinal health and disease.

Hdl Handle:
http://hdl.handle.net/10147/207483
Title:
Estrogen and its role in gastrointestinal health and disease.
Authors:
Hogan, Aisling M; Collins, Danielle; Baird, Alan W; Winter, Des C
Affiliation:
Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent's, University Hospital, Dublin, 4, Ireland. Aislinghogan@yahoo.com
Citation:
Int J Colorectal Dis. 2009 Dec;24(12):1367-75. Epub 2009 Aug 5.
Journal:
International journal of colorectal disease
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207483
DOI:
10.1007/s00384-009-0785-0
PubMed ID:
19655153
Abstract:
INTRODUCTION: While the concept of a role of estrogen in gastrointestinal (in particular, colonic) malignancy has generated excitement in recent years, no review has examined the role of this potent and omnipresent steroid hormone in physiological states or its contribution to the development of benign pathological processes. Understanding these effects (and mechanisms therein) may provide a platform for a deeper understanding of more complex disease processes. METHODS: A literature search was conducted using the PubMed database and the search terms were "estrogen," "estrogen AND gastrointestinal tract," "estrogen AND colon," "estrogen AND esophagus," "estrogen AND small intestine," "estrogen AND stomach," "estrogen AND gallbladder," and "estrogen AND motility." Bibliographies of extracted studies were further cross-referenced. In all, 136 full-text articles were selected for review. A logical organ-based approach was taken to enable extraction of data of clinical relevance and meaningful interpretation thereof. Insight is provided into the hypotheses, theories, controversies, and contradictions generated over the last five decades by extensive investigation of estrogen in human, animal, and cell models using techniques as diverse as autoradiographic studies of baboons to human population analysis. CONCLUSIONS: Effects from esophagus through to the colon and rectum are summarized in this first concise collection of data pertaining to estrogenic actions in gastrointestinal health and disease. Mechanisms of these actions are discussed where possible. Undoubtedly, this hormone exerts many actions yet to be elucidated, and its potential therapeutic applications remain, as yet, largely unexplored.
Language:
eng
MeSH:
Animals; *Disease; Estrogens/biosynthesis/*metabolism; Gastrointestinal Tract/*physiology; *Health; Humans; Organ Specificity
ISSN:
1432-1262 (Electronic); 0179-1958 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHogan, Aisling Men_GB
dc.contributor.authorCollins, Danielleen_GB
dc.contributor.authorBaird, Alan Wen_GB
dc.contributor.authorWinter, Des Cen_GB
dc.date.accessioned2012-02-01T10:29:06Z-
dc.date.available2012-02-01T10:29:06Z-
dc.date.issued2012-02-01T10:29:06Z-
dc.identifier.citationInt J Colorectal Dis. 2009 Dec;24(12):1367-75. Epub 2009 Aug 5.en_GB
dc.identifier.issn1432-1262 (Electronic)en_GB
dc.identifier.issn0179-1958 (Linking)en_GB
dc.identifier.pmid19655153en_GB
dc.identifier.doi10.1007/s00384-009-0785-0en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207483-
dc.description.abstractINTRODUCTION: While the concept of a role of estrogen in gastrointestinal (in particular, colonic) malignancy has generated excitement in recent years, no review has examined the role of this potent and omnipresent steroid hormone in physiological states or its contribution to the development of benign pathological processes. Understanding these effects (and mechanisms therein) may provide a platform for a deeper understanding of more complex disease processes. METHODS: A literature search was conducted using the PubMed database and the search terms were "estrogen," "estrogen AND gastrointestinal tract," "estrogen AND colon," "estrogen AND esophagus," "estrogen AND small intestine," "estrogen AND stomach," "estrogen AND gallbladder," and "estrogen AND motility." Bibliographies of extracted studies were further cross-referenced. In all, 136 full-text articles were selected for review. A logical organ-based approach was taken to enable extraction of data of clinical relevance and meaningful interpretation thereof. Insight is provided into the hypotheses, theories, controversies, and contradictions generated over the last five decades by extensive investigation of estrogen in human, animal, and cell models using techniques as diverse as autoradiographic studies of baboons to human population analysis. CONCLUSIONS: Effects from esophagus through to the colon and rectum are summarized in this first concise collection of data pertaining to estrogenic actions in gastrointestinal health and disease. Mechanisms of these actions are discussed where possible. Undoubtedly, this hormone exerts many actions yet to be elucidated, and its potential therapeutic applications remain, as yet, largely unexplored.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.mesh*Diseaseen_GB
dc.subject.meshEstrogens/biosynthesis/*metabolismen_GB
dc.subject.meshGastrointestinal Tract/*physiologyen_GB
dc.subject.mesh*Healthen_GB
dc.subject.meshHumansen_GB
dc.subject.meshOrgan Specificityen_GB
dc.titleEstrogen and its role in gastrointestinal health and disease.en_GB
dc.contributor.departmentInstitute for Clinical Outcomes Research and Education (iCORE), St. Vincent's, University Hospital, Dublin, 4, Ireland. Aislinghogan@yahoo.comen_GB
dc.identifier.journalInternational journal of colorectal diseaseen_GB
dc.description.provinceLeinster-

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