Microbial and viral pathogens in colorectal cancer.

Hdl Handle:
http://hdl.handle.net/10147/207482
Title:
Microbial and viral pathogens in colorectal cancer.
Authors:
Collins, Danielle; Hogan, Aisling M; Winter, Desmond C
Affiliation:
St Vincent's University Hospital and University College Dublin, Dublin 4,, Ireland.
Citation:
Lancet Oncol. 2011 May;12(5):504-12. Epub 2010 Nov 8.
Journal:
The lancet oncology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207482
DOI:
10.1016/S1470-2045(10)70186-8
PubMed ID:
21067973
Abstract:
The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.
Language:
eng
MeSH:
Alphapapillomavirus; Bacterial Infections/*complications/metabolism/microbiology/physiopathology; Bacterial Toxins/*adverse effects; Bacteroides; Cell Transformation, Neoplastic/chemically induced/*metabolism; Colorectal Neoplasms/*microbiology/physiopathology/*virology; Cyclooxygenase 2/metabolism; Cytomegalovirus; DNA Damage; Escherichia coli; Free Radicals/metabolism; Helicobacter pylori; Herpesvirus 4, Human; Humans; Inflammation/*metabolism/physiopathology; JC Virus; NF-kappa B/metabolism; Neovascularization, Pathologic/*metabolism/physiopathology; Streptococcus bovis; Virus Diseases/*complications/metabolism/physiopathology/virology
ISSN:
1474-5488 (Electronic); 1470-2045 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCollins, Danielleen_GB
dc.contributor.authorHogan, Aisling Men_GB
dc.contributor.authorWinter, Desmond Cen_GB
dc.date.accessioned2012-02-01T10:29:05Z-
dc.date.available2012-02-01T10:29:05Z-
dc.date.issued2012-02-01T10:29:05Z-
dc.identifier.citationLancet Oncol. 2011 May;12(5):504-12. Epub 2010 Nov 8.en_GB
dc.identifier.issn1474-5488 (Electronic)en_GB
dc.identifier.issn1470-2045 (Linking)en_GB
dc.identifier.pmid21067973en_GB
dc.identifier.doi10.1016/S1470-2045(10)70186-8en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207482-
dc.description.abstractThe heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.en_GB
dc.language.isoengen_GB
dc.subject.meshAlphapapillomavirusen_GB
dc.subject.meshBacterial Infections/*complications/metabolism/microbiology/physiopathologyen_GB
dc.subject.meshBacterial Toxins/*adverse effectsen_GB
dc.subject.meshBacteroidesen_GB
dc.subject.meshCell Transformation, Neoplastic/chemically induced/*metabolismen_GB
dc.subject.meshColorectal Neoplasms/*microbiology/physiopathology/*virologyen_GB
dc.subject.meshCyclooxygenase 2/metabolismen_GB
dc.subject.meshCytomegalovirusen_GB
dc.subject.meshDNA Damageen_GB
dc.subject.meshEscherichia colien_GB
dc.subject.meshFree Radicals/metabolismen_GB
dc.subject.meshHelicobacter pylorien_GB
dc.subject.meshHerpesvirus 4, Humanen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInflammation/*metabolism/physiopathologyen_GB
dc.subject.meshJC Virusen_GB
dc.subject.meshNF-kappa B/metabolismen_GB
dc.subject.meshNeovascularization, Pathologic/*metabolism/physiopathologyen_GB
dc.subject.meshStreptococcus bovisen_GB
dc.subject.meshVirus Diseases/*complications/metabolism/physiopathology/virologyen_GB
dc.titleMicrobial and viral pathogens in colorectal cancer.en_GB
dc.contributor.departmentSt Vincent's University Hospital and University College Dublin, Dublin 4,, Ireland.en_GB
dc.identifier.journalThe lancet oncologyen_GB
dc.description.provinceLeinster-

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