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Affiliation
St Vincent's University Hospital and University College Dublin, Dublin 4,, Ireland.Issue Date
2012-02-01T10:29:05ZMeSH
AlphapapillomavirusBacterial Infections/*complications/metabolism/microbiology/physiopathology
Bacterial Toxins/*adverse effects
Bacteroides
Cell Transformation, Neoplastic/chemically induced/*metabolism
Colorectal Neoplasms/*microbiology/physiopathology/*virology
Cyclooxygenase 2/metabolism
Cytomegalovirus
DNA Damage
Escherichia coli
Free Radicals/metabolism
Helicobacter pylori
Herpesvirus 4, Human
Humans
Inflammation/*metabolism/physiopathology
JC Virus
NF-kappa B/metabolism
Neovascularization, Pathologic/*metabolism/physiopathology
Streptococcus bovis
Virus Diseases/*complications/metabolism/physiopathology/virology
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Lancet Oncol. 2011 May;12(5):504-12. Epub 2010 Nov 8.Journal
The lancet oncologyDOI
10.1016/S1470-2045(10)70186-8PubMed ID
21067973Abstract
The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.Language
engISSN
1474-5488 (Electronic)1470-2045 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1016/S1470-2045(10)70186-8
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