Multiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype.

Hdl Handle:
http://hdl.handle.net/10147/207479
Title:
Multiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype.
Authors:
Lonergan, R; Kinsella, K; Fitzpatrick, P; Brady, J; Murray, B; Dunne, C; Hagan, R; Duggan, M; Jordan, S; McKenna, M; Hutchinson, M; Tubridy, N
Affiliation:
Department of Neurology, St Vincent's University Hospital, Elm Park, Dublin 4,, Ireland. roisin.lonergan@st-vincents.ie
Citation:
J Neurol Neurosurg Psychiatry. 2011 Mar;82(3):317-22. Epub 2011 Jan 19.
Journal:
Journal of neurology, neurosurgery, and psychiatry
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207479
DOI:
10.1136/jnnp.2010.220988
PubMed ID:
21248317
Abstract:
BACKGROUND: The relationship between prevalence of multiple sclerosis (MS) and latitude may be due to both genetic and environmental factors. The hypothesis that, in Ireland, MS prevalence is increasing and that north-south differences relate to variation in serum 25-hydroxyvitamin D (25(OH)D) levels was tested in this study. PATIENTS AND METHODS: Patients and matched control subjects were identified in counties Donegal, Wexford and South Dublin through multiple sources. Prevalence was determined. Blood samples were taken for serum 25(OH)D and serum intact parathyroid hormone measurement, and DNA was extracted. RESULTS: Prevalence in 2007 was significantly greater in Donegal (northwest) (290.3/105, 95% CI 262.3 to 321.7) compared with 2001 (184.6/105; 162 to 209.5). In Wexford (southeast), there was a non-significant increase in prevalence in 2007 compared with 2001. Prevalence was significantly higher in Donegal than in Wexford (144.8/105; 126.7 to 167.8, p<0.0001) and South Dublin (127.8/105; 111.3 to 148.2, p<0.0001). Overall, mean 25(OH)D levels were low and did not differ between patients (38.6 nmol/l) and controls (36.4 nmol/l) However, significantly more patients than controls had 25(OH)D levels <25 nmol/l (deficiency) (p=0.004). Levels of 25(OH)D (mean 50.74 nmol/l) were significantly higher in South Dublin (area with lowest prevalence) (p<0.0001) than in Donegal or Wexford. HLA DRB1*15 occurred most frequently in Donegal (greatest MS prevalence) and least frequently in South Dublin. CONCLUSION: Vitamin D deficiency is common in Ireland. Latitudinal variation in MS probably relates to an interaction between genetic factors and environment (25(OH)D levels), and MS risk may be modified by vitamin D in genetically susceptible individuals.
Language:
eng
MeSH:
Adult; Aged; Aged, 80 and over; Female; Genotype; Geography; HLA Antigens/*genetics; HLA-DR Antigens/genetics; HLA-DRB1 Chains; Humans; Ireland/epidemiology; Male; Middle Aged; Multiple Sclerosis/*epidemiology/etiology/genetics; Parathyroid Hormone/blood; Prevalence; Vitamin D/*blood; Vitamin D Deficiency/complications; Vitamins/*blood; Young Adult
ISSN:
1468-330X (Electronic); 0022-3050 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLonergan, Ren_GB
dc.contributor.authorKinsella, Ken_GB
dc.contributor.authorFitzpatrick, Pen_GB
dc.contributor.authorBrady, Jen_GB
dc.contributor.authorMurray, Ben_GB
dc.contributor.authorDunne, Cen_GB
dc.contributor.authorHagan, Ren_GB
dc.contributor.authorDuggan, Men_GB
dc.contributor.authorJordan, Sen_GB
dc.contributor.authorMcKenna, Men_GB
dc.contributor.authorHutchinson, Men_GB
dc.contributor.authorTubridy, Nen_GB
dc.date.accessioned2012-02-01T10:28:59Z-
dc.date.available2012-02-01T10:28:59Z-
dc.date.issued2012-02-01T10:28:59Z-
dc.identifier.citationJ Neurol Neurosurg Psychiatry. 2011 Mar;82(3):317-22. Epub 2011 Jan 19.en_GB
dc.identifier.issn1468-330X (Electronic)en_GB
dc.identifier.issn0022-3050 (Linking)en_GB
dc.identifier.pmid21248317en_GB
dc.identifier.doi10.1136/jnnp.2010.220988en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207479-
dc.description.abstractBACKGROUND: The relationship between prevalence of multiple sclerosis (MS) and latitude may be due to both genetic and environmental factors. The hypothesis that, in Ireland, MS prevalence is increasing and that north-south differences relate to variation in serum 25-hydroxyvitamin D (25(OH)D) levels was tested in this study. PATIENTS AND METHODS: Patients and matched control subjects were identified in counties Donegal, Wexford and South Dublin through multiple sources. Prevalence was determined. Blood samples were taken for serum 25(OH)D and serum intact parathyroid hormone measurement, and DNA was extracted. RESULTS: Prevalence in 2007 was significantly greater in Donegal (northwest) (290.3/105, 95% CI 262.3 to 321.7) compared with 2001 (184.6/105; 162 to 209.5). In Wexford (southeast), there was a non-significant increase in prevalence in 2007 compared with 2001. Prevalence was significantly higher in Donegal than in Wexford (144.8/105; 126.7 to 167.8, p<0.0001) and South Dublin (127.8/105; 111.3 to 148.2, p<0.0001). Overall, mean 25(OH)D levels were low and did not differ between patients (38.6 nmol/l) and controls (36.4 nmol/l) However, significantly more patients than controls had 25(OH)D levels <25 nmol/l (deficiency) (p=0.004). Levels of 25(OH)D (mean 50.74 nmol/l) were significantly higher in South Dublin (area with lowest prevalence) (p<0.0001) than in Donegal or Wexford. HLA DRB1*15 occurred most frequently in Donegal (greatest MS prevalence) and least frequently in South Dublin. CONCLUSION: Vitamin D deficiency is common in Ireland. Latitudinal variation in MS probably relates to an interaction between genetic factors and environment (25(OH)D levels), and MS risk may be modified by vitamin D in genetically susceptible individuals.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshGeographyen_GB
dc.subject.meshHLA Antigens/*geneticsen_GB
dc.subject.meshHLA-DR Antigens/geneticsen_GB
dc.subject.meshHLA-DRB1 Chainsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMultiple Sclerosis/*epidemiology/etiology/geneticsen_GB
dc.subject.meshParathyroid Hormone/blooden_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshVitamin D/*blooden_GB
dc.subject.meshVitamin D Deficiency/complicationsen_GB
dc.subject.meshVitamins/*blooden_GB
dc.subject.meshYoung Adulten_GB
dc.titleMultiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype.en_GB
dc.contributor.departmentDepartment of Neurology, St Vincent's University Hospital, Elm Park, Dublin 4,, Ireland. roisin.lonergan@st-vincents.ieen_GB
dc.identifier.journalJournal of neurology, neurosurgery, and psychiatryen_GB
dc.description.provinceLeinster-
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