Obstructive sleep apnea in chronic obstructive pulmonary disease patients.

Hdl Handle:
http://hdl.handle.net/10147/207475
Title:
Obstructive sleep apnea in chronic obstructive pulmonary disease patients.
Authors:
Lee, Ruth; McNicholas, Walter T
Affiliation:
Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin,, Ireland.
Citation:
Curr Opin Pulm Med. 2011 Mar;17(2):79-83.
Journal:
Current opinion in pulmonary medicine
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207475
DOI:
10.1097/MCP.0b013e32834317bb
PubMed ID:
21169840
Abstract:
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) represent two of the most prevalent chronic respiratory disorders and cardiovascular diseases are major co-morbidities in both. Co-existence of both disorders (overlap syndrome) occurs in 1% of adults and overlap patients have worse nocturnal hypoxemia and hypercapnia than COPD and OSA patients alone. The present review discusses recent data concerning the pathophysiological and clinical significance of the overlap syndrome. RECENT FINDINGS: The severity of obstructive ventilatory impairment and hyperinflation, especially the inspiratory capacity to total lung capacity (TLC) ratio, correlates with the severity of sleep-related breathing disturbances. Early treatment with continuous positive airway pressure (CPAP) improves survival, reduces hospitalization and pulmonary hypertension, and also reduces hypoxemia. Evidence of systemic inflammation and oxidative stress in COPD and sleep apnea provides insight into potential interactions between both disorders that may predispose to cardiovascular disease. Long-term outcome studies of overlap patients currently underway should provide further evidence of the clinical significance of the overlap syndrome. SUMMARY: Studies of overlap syndrome patients at a clinical, physiological and molecular level should provide insight into disease mechanisms and consequences of COPD and sleep apnea, in addition to identifying potential relationships with cardiovascular disease.
Language:
eng
MeSH:
Anoxia/etiology/physiopathology; Cardiovascular Diseases/epidemiology/physiopathology; Comorbidity; Humans; Hypercapnia/etiology/physiopathology; Inflammation/physiopathology; Oxidative Stress/physiology; Prevalence; Pulmonary Disease, Chronic Obstructive/*epidemiology/physiopathology; Sleep Apnea, Obstructive/*epidemiology/physiopathology; Syndrome
ISSN:
1531-6971 (Electronic); 1070-5287 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, Ruthen_GB
dc.contributor.authorMcNicholas, Walter Ten_GB
dc.date.accessioned2012-02-01T10:28:52Z-
dc.date.available2012-02-01T10:28:52Z-
dc.date.issued2012-02-01T10:28:52Z-
dc.identifier.citationCurr Opin Pulm Med. 2011 Mar;17(2):79-83.en_GB
dc.identifier.issn1531-6971 (Electronic)en_GB
dc.identifier.issn1070-5287 (Linking)en_GB
dc.identifier.pmid21169840en_GB
dc.identifier.doi10.1097/MCP.0b013e32834317bben_GB
dc.identifier.urihttp://hdl.handle.net/10147/207475-
dc.description.abstractPURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) represent two of the most prevalent chronic respiratory disorders and cardiovascular diseases are major co-morbidities in both. Co-existence of both disorders (overlap syndrome) occurs in 1% of adults and overlap patients have worse nocturnal hypoxemia and hypercapnia than COPD and OSA patients alone. The present review discusses recent data concerning the pathophysiological and clinical significance of the overlap syndrome. RECENT FINDINGS: The severity of obstructive ventilatory impairment and hyperinflation, especially the inspiratory capacity to total lung capacity (TLC) ratio, correlates with the severity of sleep-related breathing disturbances. Early treatment with continuous positive airway pressure (CPAP) improves survival, reduces hospitalization and pulmonary hypertension, and also reduces hypoxemia. Evidence of systemic inflammation and oxidative stress in COPD and sleep apnea provides insight into potential interactions between both disorders that may predispose to cardiovascular disease. Long-term outcome studies of overlap patients currently underway should provide further evidence of the clinical significance of the overlap syndrome. SUMMARY: Studies of overlap syndrome patients at a clinical, physiological and molecular level should provide insight into disease mechanisms and consequences of COPD and sleep apnea, in addition to identifying potential relationships with cardiovascular disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAnoxia/etiology/physiopathologyen_GB
dc.subject.meshCardiovascular Diseases/epidemiology/physiopathologyen_GB
dc.subject.meshComorbidityen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypercapnia/etiology/physiopathologyen_GB
dc.subject.meshInflammation/physiopathologyen_GB
dc.subject.meshOxidative Stress/physiologyen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshPulmonary Disease, Chronic Obstructive/*epidemiology/physiopathologyen_GB
dc.subject.meshSleep Apnea, Obstructive/*epidemiology/physiopathologyen_GB
dc.subject.meshSyndromeen_GB
dc.titleObstructive sleep apnea in chronic obstructive pulmonary disease patients.en_GB
dc.contributor.departmentPulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin,, Ireland.en_GB
dc.identifier.journalCurrent opinion in pulmonary medicineen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.