Late-onset CMV disease following CMV prophylaxis.

Hdl Handle:
http://hdl.handle.net/10147/207471
Title:
Late-onset CMV disease following CMV prophylaxis.
Authors:
Donnelly, C; Kennedy, F; Keane, C; Schaffer, K; McCormick, P A
Affiliation:
Pharmacy Department, St Vincent's University Hospital, Elm Park, Dublin 4,, Ireland. c.donnelly@st-vincents.ie
Citation:
Ir J Med Sci. 2009 Sep;178(3):333-6. Epub 2009 Apr 2.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207471
DOI:
10.1007/s11845-009-0327-3
PubMed ID:
19340518
Abstract:
BACKGROUND: Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. AIMS: To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. METHODS: Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. RESULTS: The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. CONCLUSIONS: The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage.
Language:
eng
MeSH:
Adolescent; Adult; Aged; Antiviral Agents/therapeutic use; Confidence Intervals; *Cytomegalovirus; Cytomegalovirus Infections/drug therapy/*prevention & control; Female; Ganciclovir/*analogs & derivatives/therapeutic use; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk Factors; Time Factors; Young Adult
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDonnelly, Cen_GB
dc.contributor.authorKennedy, Fen_GB
dc.contributor.authorKeane, Cen_GB
dc.contributor.authorSchaffer, Ken_GB
dc.contributor.authorMcCormick, P Aen_GB
dc.date.accessioned2012-02-01T10:28:45Z-
dc.date.available2012-02-01T10:28:45Z-
dc.date.issued2012-02-01T10:28:45Z-
dc.identifier.citationIr J Med Sci. 2009 Sep;178(3):333-6. Epub 2009 Apr 2.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid19340518en_GB
dc.identifier.doi10.1007/s11845-009-0327-3en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207471-
dc.description.abstractBACKGROUND: Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised. AIMS: To investigate the incidence and the time of detection of CMV infections in liver transplant recipients who received CMV prophylaxis. METHODS: Retrospective review of 64 high- and moderate-risk patients with 1 year of follow-up. RESULTS: The incidence of CMV infection was 12.5%, with 4.7% disease. All cases of symptomatic CMV disease were of late-onset. CONCLUSIONS: The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAntiviral Agents/therapeutic useen_GB
dc.subject.meshConfidence Intervalsen_GB
dc.subject.mesh*Cytomegalovirusen_GB
dc.subject.meshCytomegalovirus Infections/drug therapy/*prevention & controlen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGanciclovir/*analogs & derivatives/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIncidenceen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshYoung Adulten_GB
dc.titleLate-onset CMV disease following CMV prophylaxis.en_GB
dc.contributor.departmentPharmacy Department, St Vincent's University Hospital, Elm Park, Dublin 4,, Ireland. c.donnelly@st-vincents.ieen_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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