Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.

Hdl Handle:
http://hdl.handle.net/10147/207468
Title:
Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.
Authors:
Cooley, Sharon M; Donnelly, Jennifer C; Geary, Michael P; Rodeck, Charles H; Hindmarsh, Peter C
Affiliation:
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com
Citation:
J Matern Fetal Neonatal Med. 2010 Jul;23(7):658-61.
Journal:
The journal of maternal-fetal & neonatal medicine : the official journal of the, European Association of Perinatal Medicine, the Federation of Asia and Oceania, Perinatal Societies, the International Society of Perinatal Obstetricians
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207468
DOI:
10.3109/14767050903301033
PubMed ID:
20540659
Abstract:
OBJECTIVE: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET). METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET. RESULTS: There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET. CONCLUSIONS: Maternal IGF-2 has a significant positive correlation with PET.
Language:
eng
MeSH:
Adult; Cohort Studies; Female; Humans; Hypertension, Pregnancy-Induced/*blood/diagnosis; Infant, Newborn; Infant, Newborn, Diseases/epidemiology; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins/*blood; Insulin-Like Growth Factor I/*analysis; Insulin-Like Growth Factor II/*analysis; Intensive Care Units, Neonatal/statistics & numerical data; *Mothers; Patient Admission/statistics & numerical data; Pregnancy; Pregnancy Outcome; Prognosis
ISSN:
1476-4954 (Electronic); 1476-4954 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCooley, Sharon Men_GB
dc.contributor.authorDonnelly, Jennifer Cen_GB
dc.contributor.authorGeary, Michael Pen_GB
dc.contributor.authorRodeck, Charles Hen_GB
dc.contributor.authorHindmarsh, Peter Cen_GB
dc.date.accessioned2012-02-01T10:37:37Z-
dc.date.available2012-02-01T10:37:37Z-
dc.date.issued2012-02-01T10:37:37Z-
dc.identifier.citationJ Matern Fetal Neonatal Med. 2010 Jul;23(7):658-61.en_GB
dc.identifier.issn1476-4954 (Electronic)en_GB
dc.identifier.issn1476-4954 (Linking)en_GB
dc.identifier.pmid20540659en_GB
dc.identifier.doi10.3109/14767050903301033en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207468-
dc.description.abstractOBJECTIVE: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET). METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET. RESULTS: There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET. CONCLUSIONS: Maternal IGF-2 has a significant positive correlation with PET.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypertension, Pregnancy-Induced/*blood/diagnosisen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshInfant, Newborn, Diseases/epidemiologyen_GB
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3en_GB
dc.subject.meshInsulin-Like Growth Factor Binding Proteins/*blooden_GB
dc.subject.meshInsulin-Like Growth Factor I/*analysisen_GB
dc.subject.meshInsulin-Like Growth Factor II/*analysisen_GB
dc.subject.meshIntensive Care Units, Neonatal/statistics & numerical dataen_GB
dc.subject.mesh*Mothersen_GB
dc.subject.meshPatient Admission/statistics & numerical dataen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Outcomeen_GB
dc.subject.meshPrognosisen_GB
dc.titleMaternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.en_GB
dc.contributor.departmentRotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comen_GB
dc.identifier.journalThe journal of maternal-fetal & neonatal medicine : the official journal of the, European Association of Perinatal Medicine, the Federation of Asia and Oceania, Perinatal Societies, the International Society of Perinatal Obstetriciansen_GB
dc.description.provinceLeinster-

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