Hdl Handle:
http://hdl.handle.net/10147/207446
Title:
Hepatitis B virus infection in children.
Authors:
O'Gorman, C S; O'Connell, K; Broderick, A M; Butler, K M
Affiliation:
Our Lady's Children's Hospital, Crumlin, Dublin.
Citation:
Ir Med J. 2009 Nov-Dec;102(10):328-31.
Journal:
Irish medical journal
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207446
PubMed ID:
20108802
Abstract:
Recent increases in Hepatitis B virus (HBV) infection prompted us to characterize HBV-infected children in Ireland and to audit management, by reviewing prospectively gathered data. Of 46 children (29 [63%] male), median age at presentation was 8.1 years (range 0.6-17.6), monitoring duration was 22.5 months (range 1-101), 23/46 (50%) were European (including 9 [19.6%] Irish), 15 (32.6%) African and 9 (19.6%) Asian. Acquisition was vertical (25/46 [54.3%]), horizontal (5/46 [10.9%]), unknown (16/46 [34.8%]). HBV-DNA was >100,000,000 cpm in 20/32 (62.5%) with chronic infection. Hepatitis B e antigen (HBeAg) was detected in 32/44 (72.7%). We estimate that universal neonatal vaccination (UNV-HBV) could have prevented 22% of cases, and could limit further horizontal HBV spread. This supports the recent introduction of UNV-HBV.
Language:
eng
MeSH:
Adolescent; Child; Child, Preschool; Female; Hepatitis B/*epidemiology/prevention & control/transmission; Hepatitis B Vaccines/administration & dosage; Humans; Infant; Ireland/epidemiology; Male; Polymerase Chain Reaction; Prevalence; Prospective Studies
ISSN:
0332-3102 (Print); 0332-3102 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Gorman, C Sen_GB
dc.contributor.authorO'Connell, Ken_GB
dc.contributor.authorBroderick, A Men_GB
dc.contributor.authorButler, K Men_GB
dc.date.accessioned2012-02-01T10:25:13Z-
dc.date.available2012-02-01T10:25:13Z-
dc.date.issued2012-02-01T10:25:13Z-
dc.identifier.citationIr Med J. 2009 Nov-Dec;102(10):328-31.en_GB
dc.identifier.issn0332-3102 (Print)en_GB
dc.identifier.issn0332-3102 (Linking)en_GB
dc.identifier.pmid20108802en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207446-
dc.description.abstractRecent increases in Hepatitis B virus (HBV) infection prompted us to characterize HBV-infected children in Ireland and to audit management, by reviewing prospectively gathered data. Of 46 children (29 [63%] male), median age at presentation was 8.1 years (range 0.6-17.6), monitoring duration was 22.5 months (range 1-101), 23/46 (50%) were European (including 9 [19.6%] Irish), 15 (32.6%) African and 9 (19.6%) Asian. Acquisition was vertical (25/46 [54.3%]), horizontal (5/46 [10.9%]), unknown (16/46 [34.8%]). HBV-DNA was >100,000,000 cpm in 20/32 (62.5%) with chronic infection. Hepatitis B e antigen (HBeAg) was detected in 32/44 (72.7%). We estimate that universal neonatal vaccination (UNV-HBV) could have prevented 22% of cases, and could limit further horizontal HBV spread. This supports the recent introduction of UNV-HBV.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshChilden_GB
dc.subject.meshChild, Preschoolen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHepatitis B/*epidemiology/prevention & control/transmissionen_GB
dc.subject.meshHepatitis B Vaccines/administration & dosageen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfanten_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshPolymerase Chain Reactionen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshProspective Studiesen_GB
dc.titleHepatitis B virus infection in children.en_GB
dc.contributor.departmentOur Lady's Children's Hospital, Crumlin, Dublin.en_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinster-
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.