Systematic review and metaanalysis of statins for heterozygous familial hypercholesterolemia in children: evaluation of cholesterol changes and side effects.

Hdl Handle:
http://hdl.handle.net/10147/207418
Title:
Systematic review and metaanalysis of statins for heterozygous familial hypercholesterolemia in children: evaluation of cholesterol changes and side effects.
Authors:
O'Gorman, Clodagh S; Higgins, Mary F; O'Neill, Michael B
Affiliation:
Department of Paediatrics, Our Lady's Children's Hospital, Crumlin, Dublin,, Ireland. Clodagh.ogorman@sickkids.ca
Citation:
Pediatr Cardiol. 2009 May;30(4):482-9. Epub 2009 Feb 3.
Journal:
Pediatric cardiology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207418
DOI:
10.1007/s00246-008-9364-3
PubMed ID:
19189168
Abstract:
Heterozygous familial hypercholesterolemia (heFH) affects 1 in 500 individuals. Evidence supports the low-density lipoprotein (LDL)-lowering effect of statins for adults with heFH. However, there are concerns regarding the treatment children with heFH. By performing a systematic review and metaanalysis of the published literature, this study aimed to evaluate the efficacy and safety of statins used for children with heFH. A systematic review was performed by searching multiple medical databases and citations to identify reports of randomized controlled trials of statins used to treat children with heFH. The trials were retrieved, reviewed, and subjected to metaanalysis. The search yielded 2,174 titles. Of the 63 studies retrieved and reviewed, 56 were excluded, 7 were included in the systematic review, and 4 were included in the metaanalysis. Significant heterogeneity was detected. The metaanalysis showed significant LDL lowering, high-density lipoprotein (HDL) cholesterol elevation, and increases in height and weight with statins. The metaanalysis could not be performed for many side effects of statins, but individual trials showed no significant side effects. Quality assessment showed methodologic concerns, with potential for bias. For example, six trials analyzed statin effects without intention to treat despite such a stated intention. Metaanalysis shows significant LDL lowering with statin treatment. Further studies, including epidemiologic and multicenter studies, are required.
Language:
eng
MeSH:
Child; Cholesterol, LDL/*blood/drug effects; Female; Heterozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse; effects/pharmacology/*therapeutic use; Hyperlipoproteinemia Type II/*blood/*drug therapy; Male; Treatment Outcome
ISSN:
1432-1971 (Electronic); 0172-0643 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Gorman, Clodagh Sen_GB
dc.contributor.authorHiggins, Mary Fen_GB
dc.contributor.authorO'Neill, Michael Ben_GB
dc.date.accessioned2012-02-01T10:24:30Z-
dc.date.available2012-02-01T10:24:30Z-
dc.date.issued2012-02-01T10:24:30Z-
dc.identifier.citationPediatr Cardiol. 2009 May;30(4):482-9. Epub 2009 Feb 3.en_GB
dc.identifier.issn1432-1971 (Electronic)en_GB
dc.identifier.issn0172-0643 (Linking)en_GB
dc.identifier.pmid19189168en_GB
dc.identifier.doi10.1007/s00246-008-9364-3en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207418-
dc.description.abstractHeterozygous familial hypercholesterolemia (heFH) affects 1 in 500 individuals. Evidence supports the low-density lipoprotein (LDL)-lowering effect of statins for adults with heFH. However, there are concerns regarding the treatment children with heFH. By performing a systematic review and metaanalysis of the published literature, this study aimed to evaluate the efficacy and safety of statins used for children with heFH. A systematic review was performed by searching multiple medical databases and citations to identify reports of randomized controlled trials of statins used to treat children with heFH. The trials were retrieved, reviewed, and subjected to metaanalysis. The search yielded 2,174 titles. Of the 63 studies retrieved and reviewed, 56 were excluded, 7 were included in the systematic review, and 4 were included in the metaanalysis. Significant heterogeneity was detected. The metaanalysis showed significant LDL lowering, high-density lipoprotein (HDL) cholesterol elevation, and increases in height and weight with statins. The metaanalysis could not be performed for many side effects of statins, but individual trials showed no significant side effects. Quality assessment showed methodologic concerns, with potential for bias. For example, six trials analyzed statin effects without intention to treat despite such a stated intention. Metaanalysis shows significant LDL lowering with statin treatment. Further studies, including epidemiologic and multicenter studies, are required.en_GB
dc.language.isoengen_GB
dc.subject.meshChilden_GB
dc.subject.meshCholesterol, LDL/*blood/drug effectsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHeterozygoteen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors/adverseen_GB
dc.subject.mesheffects/pharmacology/*therapeutic useen_GB
dc.subject.meshHyperlipoproteinemia Type II/*blood/*drug therapyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleSystematic review and metaanalysis of statins for heterozygous familial hypercholesterolemia in children: evaluation of cholesterol changes and side effects.en_GB
dc.contributor.departmentDepartment of Paediatrics, Our Lady's Children's Hospital, Crumlin, Dublin,, Ireland. Clodagh.ogorman@sickkids.caen_GB
dc.identifier.journalPediatric cardiologyen_GB
dc.description.provinceLeinster-

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