Idiopathic neonatal necrotising fasciitis caused by community-acquired MSSA encoding Panton Valentine Leukocidin genes.

Hdl Handle:
http://hdl.handle.net/10147/207403
Title:
Idiopathic neonatal necrotising fasciitis caused by community-acquired MSSA encoding Panton Valentine Leukocidin genes.
Authors:
Dunlop, Rebecca L E; Eadie, Patricia
Affiliation:
Department of Plastic and Reconstructive Surgery, Our Lady's Children's Hospital,, Crumlin, Dublin 12, Ireland. rledunlop@gmail.com
Citation:
J Plast Reconstr Aesthet Surg. 2011 Nov;64(11):1522-4. Epub 2011 Apr 20.
Journal:
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207403
DOI:
10.1016/j.bjps.2011.03.041
PubMed ID:
21511548
Abstract:
Neonatal necrotising fasciitis is very rare in comparison to the adult presentation of the disease and a Plastic Surgeon may only encounter one such case during his or her career. Often this is initially misdiagnosed and managed as simple cellulitis. It generally affects previously healthy babies, the site is often the lower back area and a history of minor skin trauma may be elicited. The causative organism is usually Streptococcus or polymicrobial, as is the case in the adult population. We present the case of a previously healthy 11-day-old infant with idiopathic, rapidly progressive necrotising fasciitis of the back, cause by Methicillin sensitive Staphylococcus aureus (MSSA) infection. The strain was isolated and found to encode the Panton-Valentine Leukocidin genes, which have been associated with particularly severe necrotising infections in other sites, with high mortality. These strains are the subject of specific treatment and eradication guidance in the UK but awareness of this and the importance of obtaining detailed culture typing is likely to be low amongst Plastic Surgeons.
Language:
eng
MeSH:
Bacterial Toxins/genetics; Bacterial Typing Techniques; Buttocks; Combined Modality Therapy; Community-Acquired Infections/*microbiology/therapy; Exotoxins/genetics; Fasciitis, Necrotizing/*microbiology/therapy; Gene Transfer, Horizontal/genetics; Humans; Infant, Newborn; Leukocidins/genetics; Male; Methicillin Resistance/genetics; Microbial Sensitivity Tests; Staphylococcal Infections/*microbiology/therapy; Staphylococcus aureus/genetics
ISSN:
1878-0539 (Electronic); 1748-6815 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDunlop, Rebecca L Een_GB
dc.contributor.authorEadie, Patriciaen_GB
dc.date.accessioned2012-02-01T10:24:07Z-
dc.date.available2012-02-01T10:24:07Z-
dc.date.issued2012-02-01T10:24:07Z-
dc.identifier.citationJ Plast Reconstr Aesthet Surg. 2011 Nov;64(11):1522-4. Epub 2011 Apr 20.en_GB
dc.identifier.issn1878-0539 (Electronic)en_GB
dc.identifier.issn1748-6815 (Linking)en_GB
dc.identifier.pmid21511548en_GB
dc.identifier.doi10.1016/j.bjps.2011.03.041en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207403-
dc.description.abstractNeonatal necrotising fasciitis is very rare in comparison to the adult presentation of the disease and a Plastic Surgeon may only encounter one such case during his or her career. Often this is initially misdiagnosed and managed as simple cellulitis. It generally affects previously healthy babies, the site is often the lower back area and a history of minor skin trauma may be elicited. The causative organism is usually Streptococcus or polymicrobial, as is the case in the adult population. We present the case of a previously healthy 11-day-old infant with idiopathic, rapidly progressive necrotising fasciitis of the back, cause by Methicillin sensitive Staphylococcus aureus (MSSA) infection. The strain was isolated and found to encode the Panton-Valentine Leukocidin genes, which have been associated with particularly severe necrotising infections in other sites, with high mortality. These strains are the subject of specific treatment and eradication guidance in the UK but awareness of this and the importance of obtaining detailed culture typing is likely to be low amongst Plastic Surgeons.en_GB
dc.language.isoengen_GB
dc.subject.meshBacterial Toxins/geneticsen_GB
dc.subject.meshBacterial Typing Techniquesen_GB
dc.subject.meshButtocksen_GB
dc.subject.meshCombined Modality Therapyen_GB
dc.subject.meshCommunity-Acquired Infections/*microbiology/therapyen_GB
dc.subject.meshExotoxins/geneticsen_GB
dc.subject.meshFasciitis, Necrotizing/*microbiology/therapyen_GB
dc.subject.meshGene Transfer, Horizontal/geneticsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshLeukocidins/geneticsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMethicillin Resistance/geneticsen_GB
dc.subject.meshMicrobial Sensitivity Testsen_GB
dc.subject.meshStaphylococcal Infections/*microbiology/therapyen_GB
dc.subject.meshStaphylococcus aureus/geneticsen_GB
dc.titleIdiopathic neonatal necrotising fasciitis caused by community-acquired MSSA encoding Panton Valentine Leukocidin genes.en_GB
dc.contributor.departmentDepartment of Plastic and Reconstructive Surgery, Our Lady's Children's Hospital,, Crumlin, Dublin 12, Ireland. rledunlop@gmail.comen_GB
dc.identifier.journalJournal of plastic, reconstructive & aesthetic surgery : JPRASen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.