EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force.

Hdl Handle:
http://hdl.handle.net/10147/207346
Title:
EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force.
Affiliation:
Umea University, Umea, Sweden University of Edinburgh, Edinburgh, UK Centre, Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland , Hospital de Santa Maria, Lisbon, Portugal University of Turin and San Giovanni, Hospital, Turin, Italy University of Leuven and VIB, Leuven, Belgium Trinity, College and Beaumont Hospital, Dublin, Ireland Medizinische Hochschule Hannover, , Germany School of Clinical and Experimental Medicine, University of Birmingham, and Queen Elizabeth Hospital, Birmingham, UK Hopital de la Salpetriere, Paris,, France University of Milan Medical School, Milan, Italy Jagiellonian University, Medical College, Krakow, Poland Munich University Hospital, Munich, Germany, Kantonsspital St Gallen and University Hospital Basel, Basel, Switzerland.
Citation:
Eur J Neurol. 2011 Sep 14. doi: 10.1111/j.1468-1331.2011.03501.x.
Journal:
European journal of neurology : the official journal of the European Federation, of Neurological Societies
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207346
DOI:
10.1111/j.1468-1331.2011.03501.x
PubMed ID:
21914052
Abstract:
Background: The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. Objectives: To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an expert panel. Methods: All available medical reference systems were searched, and original papers, meta-analyses, review papers, book chapters and guidelines recommendations were reviewed. The final literature search was performed in February 2011. Recommendations were reached by consensus. Recommendations: Patients with symptoms suggestive of ALS should be assessed as soon as possible by an experienced neurologist. Early diagnosis should be pursued, and investigations, including neurophysiology, performed with a high priority. The patient should be informed of the diagnosis by a consultant with a good knowledge of the patient and the disease. Following diagnosis, the patient and relatives/carers should receive regular support from a multidisciplinary care team. Medication with riluzole should be initiated as early as possible. Control of symptoms such as sialorrhoea, thick mucus, emotional lability, cramps, spasticity and pain should be attempted. Percutaneous endoscopic gastrostomy feeding improves nutrition and quality of life, and gastrostomy tubes should be placed before respiratory insufficiency develops. Non-invasive positive-pressure ventilation also improves survival and quality of life. Maintaining the patient's ability to communicate is essential. During the entire course of the disease, every effort should be made to maintain patient autonomy. Advance directives for palliative end-of-life care should be discussed early with the patient and carers, respecting the patient's social and cultural background.
Language:
ENG
ISSN:
1468-1331 (Electronic); 1351-5101 (Linking)

Full metadata record

DC FieldValue Language
dc.date.accessioned2012-02-01T10:05:22Z-
dc.date.available2012-02-01T10:05:22Z-
dc.date.issued2012-02-01T10:05:22Z-
dc.identifier.citationEur J Neurol. 2011 Sep 14. doi: 10.1111/j.1468-1331.2011.03501.x.en_GB
dc.identifier.issn1468-1331 (Electronic)en_GB
dc.identifier.issn1351-5101 (Linking)en_GB
dc.identifier.pmid21914052en_GB
dc.identifier.doi10.1111/j.1468-1331.2011.03501.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207346-
dc.description.abstractBackground: The evidence base for the diagnosis and management of amyotrophic lateral sclerosis (ALS) is weak. Objectives: To provide evidence-based or expert recommendations for the diagnosis and management of ALS based on a literature search and the consensus of an expert panel. Methods: All available medical reference systems were searched, and original papers, meta-analyses, review papers, book chapters and guidelines recommendations were reviewed. The final literature search was performed in February 2011. Recommendations were reached by consensus. Recommendations: Patients with symptoms suggestive of ALS should be assessed as soon as possible by an experienced neurologist. Early diagnosis should be pursued, and investigations, including neurophysiology, performed with a high priority. The patient should be informed of the diagnosis by a consultant with a good knowledge of the patient and the disease. Following diagnosis, the patient and relatives/carers should receive regular support from a multidisciplinary care team. Medication with riluzole should be initiated as early as possible. Control of symptoms such as sialorrhoea, thick mucus, emotional lability, cramps, spasticity and pain should be attempted. Percutaneous endoscopic gastrostomy feeding improves nutrition and quality of life, and gastrostomy tubes should be placed before respiratory insufficiency develops. Non-invasive positive-pressure ventilation also improves survival and quality of life. Maintaining the patient's ability to communicate is essential. During the entire course of the disease, every effort should be made to maintain patient autonomy. Advance directives for palliative end-of-life care should be discussed early with the patient and carers, respecting the patient's social and cultural background.en_GB
dc.language.isoENGen_GB
dc.titleEFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) - revised report of an EFNS task force.en_GB
dc.contributor.departmentUmea University, Umea, Sweden University of Edinburgh, Edinburgh, UK Centre, Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland , Hospital de Santa Maria, Lisbon, Portugal University of Turin and San Giovanni, Hospital, Turin, Italy University of Leuven and VIB, Leuven, Belgium Trinity, College and Beaumont Hospital, Dublin, Ireland Medizinische Hochschule Hannover, , Germany School of Clinical and Experimental Medicine, University of Birmingham, and Queen Elizabeth Hospital, Birmingham, UK Hopital de la Salpetriere, Paris,, France University of Milan Medical School, Milan, Italy Jagiellonian University, Medical College, Krakow, Poland Munich University Hospital, Munich, Germany, Kantonsspital St Gallen and University Hospital Basel, Basel, Switzerland.en_GB
dc.identifier.journalEuropean journal of neurology : the official journal of the European Federation, of Neurological Societiesen_GB
dc.description.provinceLeinster-

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