Identifying coronary artery disease in men with type 2 diabetes: osteoprotegerin, pulse wave velocity, and other biomarkers of cardiovascular risk.

Hdl Handle:
http://hdl.handle.net/10147/207325
Title:
Identifying coronary artery disease in men with type 2 diabetes: osteoprotegerin, pulse wave velocity, and other biomarkers of cardiovascular risk.
Authors:
Davenport, Colin; Ashley, David T; O'Sullivan, Eoin P; Corley, Brian T; Fitzgerald, Patricia; Agha, Amar; Thompson, Christopher J; O'Gorman, Donal J; Smith, Diarmuid
Affiliation:
Department of Diabetes and Endocrinology, Royal College of Surgeons in Ireland, Medical School, Beaumont Hospital, Dublin, Ireland. drcdavenport@gmail.com
Citation:
J Hypertens. 2011 Dec;29(12):2469-75.
Journal:
Journal of hypertension
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207325
DOI:
10.1097/HJH.0b013e32834c1e95
PubMed ID:
21970938
Abstract:
OBJECTIVES: In patients with type 2 diabetes, high serum levels of osteoprotegerin (OPG) have been associated with a greater risk of cardiovascular events. However, it remains unclear how well OPG performs when compared with traditional biomarkers of cardiovascular risk such as high-sensitivity C-reactive protein (hsCRP). Furthermore, OPG levels are also high in the presence of diabetes-related microvascular disease, and it is unclear whether OPG can distinguish microvascular disease from large-vessel atherosclerosis. The first aim of this study was to compare OPG levels against other biomarkers of cardiovascular risk in the identification of patients with documented multivessel coronary artery disease (CAD). The second aim was to compare OPG levels in patients with microvascular complications (microalbuminuria) against those with established CAD. METHODS: Three groups of male patients with type 2 diabetes were recruited: patients without microvascular complications or large-vessel atherosclerosis (n = 24), patients with microalbuminuria only (n = 23), and patients with microalbuminuria and documented multivessel CAD (n = 25). OPG, hsCRP, interleukin 6, urate, and pulse wave velocity were measured. RESULTS: Serum OPG levels were significantly higher in patients with a combination of microalbuminuria and CAD than in those with microalbuminuria alone. There were no significant differences in any of the other biomarkers between the groups. CONCLUSION: OPG was found to be superior to the other biomarkers studied in identifying patients with documented CAD. The presence of CAD was a greater determinant of serum OPG levels than microalbuminuria in our population. These findings support the use of OPG as a biomarker of cardiovascular risk.
Language:
eng
ISSN:
1473-5598 (Electronic); 0263-6352 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDavenport, Colinen_GB
dc.contributor.authorAshley, David Ten_GB
dc.contributor.authorO'Sullivan, Eoin Pen_GB
dc.contributor.authorCorley, Brian Ten_GB
dc.contributor.authorFitzgerald, Patriciaen_GB
dc.contributor.authorAgha, Amaren_GB
dc.contributor.authorThompson, Christopher Jen_GB
dc.contributor.authorO'Gorman, Donal Jen_GB
dc.contributor.authorSmith, Diarmuiden_GB
dc.date.accessioned2012-02-01T10:04:53Z-
dc.date.available2012-02-01T10:04:53Z-
dc.date.issued2012-02-01T10:04:53Z-
dc.identifier.citationJ Hypertens. 2011 Dec;29(12):2469-75.en_GB
dc.identifier.issn1473-5598 (Electronic)en_GB
dc.identifier.issn0263-6352 (Linking)en_GB
dc.identifier.pmid21970938en_GB
dc.identifier.doi10.1097/HJH.0b013e32834c1e95en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207325-
dc.description.abstractOBJECTIVES: In patients with type 2 diabetes, high serum levels of osteoprotegerin (OPG) have been associated with a greater risk of cardiovascular events. However, it remains unclear how well OPG performs when compared with traditional biomarkers of cardiovascular risk such as high-sensitivity C-reactive protein (hsCRP). Furthermore, OPG levels are also high in the presence of diabetes-related microvascular disease, and it is unclear whether OPG can distinguish microvascular disease from large-vessel atherosclerosis. The first aim of this study was to compare OPG levels against other biomarkers of cardiovascular risk in the identification of patients with documented multivessel coronary artery disease (CAD). The second aim was to compare OPG levels in patients with microvascular complications (microalbuminuria) against those with established CAD. METHODS: Three groups of male patients with type 2 diabetes were recruited: patients without microvascular complications or large-vessel atherosclerosis (n = 24), patients with microalbuminuria only (n = 23), and patients with microalbuminuria and documented multivessel CAD (n = 25). OPG, hsCRP, interleukin 6, urate, and pulse wave velocity were measured. RESULTS: Serum OPG levels were significantly higher in patients with a combination of microalbuminuria and CAD than in those with microalbuminuria alone. There were no significant differences in any of the other biomarkers between the groups. CONCLUSION: OPG was found to be superior to the other biomarkers studied in identifying patients with documented CAD. The presence of CAD was a greater determinant of serum OPG levels than microalbuminuria in our population. These findings support the use of OPG as a biomarker of cardiovascular risk.en_GB
dc.language.isoengen_GB
dc.titleIdentifying coronary artery disease in men with type 2 diabetes: osteoprotegerin, pulse wave velocity, and other biomarkers of cardiovascular risk.en_GB
dc.contributor.departmentDepartment of Diabetes and Endocrinology, Royal College of Surgeons in Ireland, Medical School, Beaumont Hospital, Dublin, Ireland. drcdavenport@gmail.comen_GB
dc.identifier.journalJournal of hypertensionen_GB
dc.description.provinceLeinster-

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