Are screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview.

Hdl Handle:
http://hdl.handle.net/10147/207273
Title:
Are screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview.
Authors:
Kelleher, Ian; Harley, Michelle; Murtagh, Aileen; Cannon, Mary
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont, Hospital, Dublin, Ireland.
Citation:
Schizophr Bull. 2011 Mar;37(2):362-9. Epub 2009 Jun 19.
Journal:
Schizophrenia bulletin
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207273
DOI:
10.1093/schbul/sbp057
PubMed ID:
19542527
Abstract:
Individuals who report psychotic-like experiences are at increased risk of future clinical psychotic disorder. They constitute a unique "high-risk" group for studying the developmental trajectory to schizophrenia and related illnesses. Previous research has used screening instruments to identify this high-risk group, but the validity of these instruments has not yet been established. We administered a screening questionnaire with 7 items designed to assess psychotic-like experiences to 334 adolescents aged 11-13 years. Detailed clinical interviews were subsequently carried out with a sample of these adolescents. We calculated sensitivity and specificity and positive predictive value (PPV) and negative predictive value (NPV) for each screening question for the specific symptom it enquired about and also in relation to any psychotic-like experience. The predictive power varied substantially between items, with the question on auditory hallucinations ("Have you ever heard voices or sounds that no one else can hear?") providing the best predictive power. For interview-verified auditory hallucinations specifically, this question had a PPV of 71.4% and an NPV of 90.4%. When assessed for its predictive power for any psychotic-like experience (including, but not limited to, auditory hallucinations), it provided a PPV of 100% and an NPV of 88.4%. Two further questions-relating to visual hallucinations and paranoid thoughts-also demonstrated good predictive power for psychotic-like experiences. Our results suggest that it may be possible to screen the general adolescent population for psychotic-like experiences with a high degree of accuracy using a short self-report questionnaire.
Language:
eng
MeSH:
Adolescent; Child; Comorbidity; Delusions/diagnosis/psychology; Early Diagnosis; Female; Hallucinations/diagnosis/psychology; Humans; *Interview, Psychological; Ireland; Male; Mass Screening/*statistics & numerical data; Mental Disorders/diagnosis/psychology; Paranoid Behavior/diagnosis/psychology; Psychometrics/statistics & numerical data; Psychotic Disorders/*diagnosis/psychology; Questionnaires; Reference Values; Reproducibility of Results; Risk Assessment/statistics & numerical data
ISSN:
1745-1701 (Electronic); 0586-7614 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKelleher, Ianen_GB
dc.contributor.authorHarley, Michelleen_GB
dc.contributor.authorMurtagh, Aileenen_GB
dc.contributor.authorCannon, Maryen_GB
dc.date.accessioned2012-02-01T10:03:43Z-
dc.date.available2012-02-01T10:03:43Z-
dc.date.issued2012-02-01T10:03:43Z-
dc.identifier.citationSchizophr Bull. 2011 Mar;37(2):362-9. Epub 2009 Jun 19.en_GB
dc.identifier.issn1745-1701 (Electronic)en_GB
dc.identifier.issn0586-7614 (Linking)en_GB
dc.identifier.pmid19542527en_GB
dc.identifier.doi10.1093/schbul/sbp057en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207273-
dc.description.abstractIndividuals who report psychotic-like experiences are at increased risk of future clinical psychotic disorder. They constitute a unique "high-risk" group for studying the developmental trajectory to schizophrenia and related illnesses. Previous research has used screening instruments to identify this high-risk group, but the validity of these instruments has not yet been established. We administered a screening questionnaire with 7 items designed to assess psychotic-like experiences to 334 adolescents aged 11-13 years. Detailed clinical interviews were subsequently carried out with a sample of these adolescents. We calculated sensitivity and specificity and positive predictive value (PPV) and negative predictive value (NPV) for each screening question for the specific symptom it enquired about and also in relation to any psychotic-like experience. The predictive power varied substantially between items, with the question on auditory hallucinations ("Have you ever heard voices or sounds that no one else can hear?") providing the best predictive power. For interview-verified auditory hallucinations specifically, this question had a PPV of 71.4% and an NPV of 90.4%. When assessed for its predictive power for any psychotic-like experience (including, but not limited to, auditory hallucinations), it provided a PPV of 100% and an NPV of 88.4%. Two further questions-relating to visual hallucinations and paranoid thoughts-also demonstrated good predictive power for psychotic-like experiences. Our results suggest that it may be possible to screen the general adolescent population for psychotic-like experiences with a high degree of accuracy using a short self-report questionnaire.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshChilden_GB
dc.subject.meshComorbidityen_GB
dc.subject.meshDelusions/diagnosis/psychologyen_GB
dc.subject.meshEarly Diagnosisen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHallucinations/diagnosis/psychologyen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Interview, Psychologicalen_GB
dc.subject.meshIrelanden_GB
dc.subject.meshMaleen_GB
dc.subject.meshMass Screening/*statistics & numerical dataen_GB
dc.subject.meshMental Disorders/diagnosis/psychologyen_GB
dc.subject.meshParanoid Behavior/diagnosis/psychologyen_GB
dc.subject.meshPsychometrics/statistics & numerical dataen_GB
dc.subject.meshPsychotic Disorders/*diagnosis/psychologyen_GB
dc.subject.meshQuestionnairesen_GB
dc.subject.meshReference Valuesen_GB
dc.subject.meshReproducibility of Resultsen_GB
dc.subject.meshRisk Assessment/statistics & numerical dataen_GB
dc.titleAre screening instruments valid for psychotic-like experiences? A validation study of screening questions for psychotic-like experiences using in-depth clinical interview.en_GB
dc.contributor.departmentDepartment of Psychiatry, Royal College of Surgeons in Ireland, Beaumont, Hospital, Dublin, Ireland.en_GB
dc.identifier.journalSchizophrenia bulletinen_GB
dc.description.provinceLeinster-

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