Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.

Hdl Handle:
http://hdl.handle.net/10147/207246
Title:
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
Authors:
Behan, Aine T; van den Hove, Daniel L A; Mueller, Lynn; Jetten, Marlon J A; Steinbusch, Harry W M; Cotter, David R; Prickaerts, Jos
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education, and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland., abehan@rcsi.ie
Citation:
Eur Neuropsychopharmacol. 2011 Jan;21(1):71-9. Epub 2010 Aug 10.
Journal:
European neuropsychopharmacology : the journal of the European College of, Neuropsychopharmacology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207246
DOI:
10.1016/j.euroneuro.2010.07.004
PubMed ID:
20702067
Abstract:
Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.
Language:
eng
MeSH:
Animals; Anxiety/pathology; Behavior, Animal; Cognition; Corticosterone/blood; Depression/pathology; Disease Models, Animal; Female; Hippocampus/*pathology; Humans; Male; Mice; Mood Disorders/pathology; Neuroglia/*pathology; Pregnancy; *Prenatal Exposure Delayed Effects; Sex Characteristics; *Stress, Psychological
ISSN:
1873-7862 (Electronic); 0924-977X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorBehan, Aine Ten_GB
dc.contributor.authorvan den Hove, Daniel L Aen_GB
dc.contributor.authorMueller, Lynnen_GB
dc.contributor.authorJetten, Marlon J Aen_GB
dc.contributor.authorSteinbusch, Harry W Men_GB
dc.contributor.authorCotter, David Ren_GB
dc.contributor.authorPrickaerts, Josen_GB
dc.date.accessioned2012-02-01T10:02:59Z-
dc.date.available2012-02-01T10:02:59Z-
dc.date.issued2012-02-01T10:02:59Z-
dc.identifier.citationEur Neuropsychopharmacol. 2011 Jan;21(1):71-9. Epub 2010 Aug 10.en_GB
dc.identifier.issn1873-7862 (Electronic)en_GB
dc.identifier.issn0924-977X (Linking)en_GB
dc.identifier.pmid20702067en_GB
dc.identifier.doi10.1016/j.euroneuro.2010.07.004en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207246-
dc.description.abstractPrenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety, schizophrenia, and autism. To determine the effects of PS on hippocampal-dependent behaviour hippocampal morphology, we examined behavioural responses and hippocampal cytoarchitecture of a maternal restraint stress paradigm of PS in C57BL6 mice. Female offspring only showed a reduction in hippocampal glial count in the pyramidal layer following PS. Additionally, only PS females showed increased depressive-like behaviour with cognitive deficits predominantly in female offspring when compared to males. This data provides evidence for functional female-specific glial deficits within the hippocampus as a consequence of PS.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshAnxiety/pathologyen_GB
dc.subject.meshBehavior, Animalen_GB
dc.subject.meshCognitionen_GB
dc.subject.meshCorticosterone/blooden_GB
dc.subject.meshDepression/pathologyen_GB
dc.subject.meshDisease Models, Animalen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHippocampus/*pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiceen_GB
dc.subject.meshMood Disorders/pathologyen_GB
dc.subject.meshNeuroglia/*pathologyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.mesh*Prenatal Exposure Delayed Effectsen_GB
dc.subject.meshSex Characteristicsen_GB
dc.subject.mesh*Stress, Psychologicalen_GB
dc.titleEvidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.en_GB
dc.contributor.departmentDepartment of Psychiatry, Royal College of Surgeons in Ireland, RCSI Education, and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland., abehan@rcsi.ieen_GB
dc.identifier.journalEuropean neuropsychopharmacology : the journal of the European College of, Neuropsychopharmacologyen_GB
dc.description.provinceLeinster-

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