Mechanisms underlying rapid aldosterone effects in the kidney.

Hdl Handle:
http://hdl.handle.net/10147/207243
Title:
Mechanisms underlying rapid aldosterone effects in the kidney.
Authors:
Thomas, Warren; Harvey, Brian J
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont , Hospital, Dublin, Ireland. wthomas@rcsi.ie
Citation:
Annu Rev Physiol. 2011 Mar 17;73:335-57.
Journal:
Annual review of physiology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207243
DOI:
10.1146/annurev-physiol-012110-142222
PubMed ID:
20809792
Abstract:
The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.
Language:
eng
MeSH:
Aldosterone/*physiology; Animals; Biological Transport/physiology; Epithelial Sodium Channel/physiology; Humans; Kidney/*physiology; Mice; Protein Kinases/physiology; Rats; Receptors, Aldosterone/*physiology; Receptors, Growth Factor/physiology; Signal Transduction/physiology; Sodium-Potassium-Exchanging ATPase/physiology; Transcription, Genetic/physiology
ISSN:
1545-1585 (Electronic); 0066-4278 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorThomas, Warrenen_GB
dc.contributor.authorHarvey, Brian Jen_GB
dc.date.accessioned2012-02-01T10:02:54Z-
dc.date.available2012-02-01T10:02:54Z-
dc.date.issued2012-02-01T10:02:54Z-
dc.identifier.citationAnnu Rev Physiol. 2011 Mar 17;73:335-57.en_GB
dc.identifier.issn1545-1585 (Electronic)en_GB
dc.identifier.issn0066-4278 (Linking)en_GB
dc.identifier.pmid20809792en_GB
dc.identifier.doi10.1146/annurev-physiol-012110-142222en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207243-
dc.description.abstractThe steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.en_GB
dc.language.isoengen_GB
dc.subject.meshAldosterone/*physiologyen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshBiological Transport/physiologyen_GB
dc.subject.meshEpithelial Sodium Channel/physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshKidney/*physiologyen_GB
dc.subject.meshMiceen_GB
dc.subject.meshProtein Kinases/physiologyen_GB
dc.subject.meshRatsen_GB
dc.subject.meshReceptors, Aldosterone/*physiologyen_GB
dc.subject.meshReceptors, Growth Factor/physiologyen_GB
dc.subject.meshSignal Transduction/physiologyen_GB
dc.subject.meshSodium-Potassium-Exchanging ATPase/physiologyen_GB
dc.subject.meshTranscription, Genetic/physiologyen_GB
dc.titleMechanisms underlying rapid aldosterone effects in the kidney.en_GB
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Beaumont , Hospital, Dublin, Ireland. wthomas@rcsi.ieen_GB
dc.identifier.journalAnnual review of physiologyen_GB
dc.description.provinceLeinster-

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