Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting.

Hdl Handle:
http://hdl.handle.net/10147/207216
Title:
Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting.
Authors:
Moloney, M A; McHugh, S; O' Donnell, D H; Casey, R G; Kavanagh, E G; Grace, P A; Fitzgerald, P; Bouchier-Hayes, D J
Affiliation:
Department of Vascular Surgery, Beaumont Hospital, Beaumont Road, Beaumont,, Dublin 9, Ireland. tmoloney90@hotmail.com
Citation:
Ir J Med Sci. 2011 Jun;180(2):375-8. Epub 2010 Nov 11.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207216
DOI:
10.1007/s11845-010-0513-3
PubMed ID:
21069574
Abstract:
BACKGOUND: Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta. AIM: We investigated whether replacement of an aneurysmal aorta with a compliant graft would result in a decrease in AI, which would thus decrease myocardial workload parameters. METHODS: Patients undergoing elective open or endovascular AAA repair were assessed with applanation tonometry and laser fluximetry pre-operatively, immediately and long-term post-operatively. RESULTS: Replacement of a small segment of abnormal conduit vessel resulted in improvements in AI, demonstrating that arterial stiffness can be surgically manipulated. CONCLUSIONS: These results reflect a decreased myocardial workload post-aortic grafting. This decrease in AI is important from a risk factor management perspective, and arterial stiffness should become a further recognised and screened for risk factor in patients with known aneurysmal disease.
Language:
eng
MeSH:
Aged; Aorta, Abdominal/physiopathology; Aortic Aneurysm, Abdominal/*physiopathology/*surgery; Blood Pressure/physiology; Elasticity/*physiology; Female; Humans; Laser-Doppler Flowmetry; Male; Manometry; Microcirculation/*physiology; Tissue Transplantation/physiology
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMoloney, M Aen_GB
dc.contributor.authorMcHugh, Sen_GB
dc.contributor.authorO' Donnell, D Hen_GB
dc.contributor.authorCasey, R Gen_GB
dc.contributor.authorKavanagh, E Gen_GB
dc.contributor.authorGrace, P Aen_GB
dc.contributor.authorFitzgerald, Pen_GB
dc.contributor.authorBouchier-Hayes, D Jen_GB
dc.date.accessioned2012-02-01T10:02:11Z-
dc.date.available2012-02-01T10:02:11Z-
dc.date.issued2012-02-01T10:02:11Z-
dc.identifier.citationIr J Med Sci. 2011 Jun;180(2):375-8. Epub 2010 Nov 11.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid21069574en_GB
dc.identifier.doi10.1007/s11845-010-0513-3en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207216-
dc.description.abstractBACKGOUND: Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta. AIM: We investigated whether replacement of an aneurysmal aorta with a compliant graft would result in a decrease in AI, which would thus decrease myocardial workload parameters. METHODS: Patients undergoing elective open or endovascular AAA repair were assessed with applanation tonometry and laser fluximetry pre-operatively, immediately and long-term post-operatively. RESULTS: Replacement of a small segment of abnormal conduit vessel resulted in improvements in AI, demonstrating that arterial stiffness can be surgically manipulated. CONCLUSIONS: These results reflect a decreased myocardial workload post-aortic grafting. This decrease in AI is important from a risk factor management perspective, and arterial stiffness should become a further recognised and screened for risk factor in patients with known aneurysmal disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAorta, Abdominal/physiopathologyen_GB
dc.subject.meshAortic Aneurysm, Abdominal/*physiopathology/*surgeryen_GB
dc.subject.meshBlood Pressure/physiologyen_GB
dc.subject.meshElasticity/*physiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLaser-Doppler Flowmetryen_GB
dc.subject.meshMaleen_GB
dc.subject.meshManometryen_GB
dc.subject.meshMicrocirculation/*physiologyen_GB
dc.subject.meshTissue Transplantation/physiologyen_GB
dc.titleComparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting.en_GB
dc.contributor.departmentDepartment of Vascular Surgery, Beaumont Hospital, Beaumont Road, Beaumont,, Dublin 9, Ireland. tmoloney90@hotmail.comen_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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