Platelet function testing: methods of assessment and clinical utility.

Hdl Handle:
http://hdl.handle.net/10147/207208
Title:
Platelet function testing: methods of assessment and clinical utility.
Authors:
Mylotte, Darren; Foley, David; Kenny, Dermot
Affiliation:
Department of Cardiology, Beaumont Hospital, Dublin, Ireland., darrenmylotte@rcsi.ie
Citation:
Cardiovasc Hematol Agents Med Chem. 2011 Jan;9(1):14-24.
Journal:
Cardiovascular & hematological agents in medicinal chemistry
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207208
PubMed ID:
21121898
Abstract:
Platelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.
Language:
eng
MeSH:
Blood Platelets/*cytology/metabolism; Flow Cytometry/methods; Humans; Platelet Activation; Platelet Aggregation; Platelet Function Tests/instrumentation/*methods; Thrombelastography/methods
ISSN:
1875-6182 (Electronic); 1871-5257 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMylotte, Darrenen_GB
dc.contributor.authorFoley, Daviden_GB
dc.contributor.authorKenny, Dermoten_GB
dc.date.accessioned2012-02-01T10:01:59Z-
dc.date.available2012-02-01T10:01:59Z-
dc.date.issued2012-02-01T10:01:59Z-
dc.identifier.citationCardiovasc Hematol Agents Med Chem. 2011 Jan;9(1):14-24.en_GB
dc.identifier.issn1875-6182 (Electronic)en_GB
dc.identifier.issn1871-5257 (Linking)en_GB
dc.identifier.pmid21121898en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207208-
dc.description.abstractPlatelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.en_GB
dc.language.isoengen_GB
dc.subject.meshBlood Platelets/*cytology/metabolismen_GB
dc.subject.meshFlow Cytometry/methodsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshPlatelet Activationen_GB
dc.subject.meshPlatelet Aggregationen_GB
dc.subject.meshPlatelet Function Tests/instrumentation/*methodsen_GB
dc.subject.meshThrombelastography/methodsen_GB
dc.titlePlatelet function testing: methods of assessment and clinical utility.en_GB
dc.contributor.departmentDepartment of Cardiology, Beaumont Hospital, Dublin, Ireland., darrenmylotte@rcsi.ieen_GB
dc.identifier.journalCardiovascular & hematological agents in medicinal chemistryen_GB
dc.description.provinceLeinster-

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