The regulation of cell growth and survival by aldosterone.

Hdl Handle:
http://hdl.handle.net/10147/207187
Title:
The regulation of cell growth and survival by aldosterone.
Authors:
Dooley, Ruth; Harvey, Brian J; Thomas, Warren
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education, and Research Centre, Beaumont Hospital, Dublin 9, Ireland. ruthdooley@rcsi.ie
Citation:
Front Biosci. 2011 Jan 1;16:440-57.
Journal:
Frontiers in bioscience : a journal and virtual library
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207187
PubMed ID:
21196180
Abstract:
The steroid hormone aldosterone is synthesized from cholesterol, mainly in the zona glomerulosa of the adrenal cortex. Aldosterone exerts its effects in the epithelial tissues of the kidney and colon and in non-epithelial tissues such as the brain and cardiovasculature. The genomic response to aldosterone involves dimerization of the mineralocorticoid receptor (MR), dissociation of heat shock proteins from MR, translocation of the aldosterone-MR complex to the nucleus and the concomitant regulation of gene expression. Rapid responses to aldosterone occur within seconds to minutes, do not involve transcription or translation and can modulate directly or indirectly the later genomic responses. Aside from the well-known effects of aldosterone on the regulation of sodium and water homeostasis, aldosterone can also produce deleterious structural changes in tissues by inducing hypertrophy and the dysregulation of proliferation and apoptosis, leading to fibrosis and tissue remodelling. Here we discuss the involvement of aldosterone-mediated rapid signalling cascades in the development of disease states such as chronic kidney disease and heart failure, and the antagonists that can inhibit these pathophysiological responses.
Language:
eng
MeSH:
11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone/*physiology; Animals; Blood Vessels/physiology; Brain/drug effects/physiopathology; Cardiovascular Diseases/physiopathology; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Humans; Kidney/drug effects/physiopathology; Kidney Diseases/physiopathology; MAP Kinase Signaling System/physiology; Myocytes, Cardiac/physiology; Nephrons/drug effects/growth & development; Receptors, Aldosterone/physiology; Receptors, Glucocorticoid/physiology; Receptors, Mineralocorticoid/drug effects/*physiology; Renin-Angiotensin System/physiology
ISSN:
1093-4715 (Electronic); 1093-4715 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDooley, Ruthen_GB
dc.contributor.authorHarvey, Brian Jen_GB
dc.contributor.authorThomas, Warrenen_GB
dc.date.accessioned2012-02-01T10:01:25Z-
dc.date.available2012-02-01T10:01:25Z-
dc.date.issued2012-02-01T10:01:25Z-
dc.identifier.citationFront Biosci. 2011 Jan 1;16:440-57.en_GB
dc.identifier.issn1093-4715 (Electronic)en_GB
dc.identifier.issn1093-4715 (Linking)en_GB
dc.identifier.pmid21196180en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207187-
dc.description.abstractThe steroid hormone aldosterone is synthesized from cholesterol, mainly in the zona glomerulosa of the adrenal cortex. Aldosterone exerts its effects in the epithelial tissues of the kidney and colon and in non-epithelial tissues such as the brain and cardiovasculature. The genomic response to aldosterone involves dimerization of the mineralocorticoid receptor (MR), dissociation of heat shock proteins from MR, translocation of the aldosterone-MR complex to the nucleus and the concomitant regulation of gene expression. Rapid responses to aldosterone occur within seconds to minutes, do not involve transcription or translation and can modulate directly or indirectly the later genomic responses. Aside from the well-known effects of aldosterone on the regulation of sodium and water homeostasis, aldosterone can also produce deleterious structural changes in tissues by inducing hypertrophy and the dysregulation of proliferation and apoptosis, leading to fibrosis and tissue remodelling. Here we discuss the involvement of aldosterone-mediated rapid signalling cascades in the development of disease states such as chronic kidney disease and heart failure, and the antagonists that can inhibit these pathophysiological responses.en_GB
dc.language.isoengen_GB
dc.subject.mesh11-beta-Hydroxysteroid Dehydrogenase Type 2en_GB
dc.subject.meshAldosterone/*physiologyen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshBlood Vessels/physiologyen_GB
dc.subject.meshBrain/drug effects/physiopathologyen_GB
dc.subject.meshCardiovascular Diseases/physiopathologyen_GB
dc.subject.meshCell Differentiation/drug effectsen_GB
dc.subject.meshCell Proliferation/drug effectsen_GB
dc.subject.meshCell Survival/drug effectsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshKidney/drug effects/physiopathologyen_GB
dc.subject.meshKidney Diseases/physiopathologyen_GB
dc.subject.meshMAP Kinase Signaling System/physiologyen_GB
dc.subject.meshMyocytes, Cardiac/physiologyen_GB
dc.subject.meshNephrons/drug effects/growth & developmenten_GB
dc.subject.meshReceptors, Aldosterone/physiologyen_GB
dc.subject.meshReceptors, Glucocorticoid/physiologyen_GB
dc.subject.meshReceptors, Mineralocorticoid/drug effects/*physiologyen_GB
dc.subject.meshRenin-Angiotensin System/physiologyen_GB
dc.titleThe regulation of cell growth and survival by aldosterone.en_GB
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education, and Research Centre, Beaumont Hospital, Dublin 9, Ireland. ruthdooley@rcsi.ieen_GB
dc.identifier.journalFrontiers in bioscience : a journal and virtual libraryen_GB
dc.description.provinceLeinster-

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