The cystic fibrosis neutrophil: a specialized yet potentially defective cell.

Hdl Handle:
http://hdl.handle.net/10147/207165
Title:
The cystic fibrosis neutrophil: a specialized yet potentially defective cell.
Authors:
Hayes, Elaine; Pohl, Kerstin; McElvaney, Noel G; Reeves, Emer P
Affiliation:
Respiratory Research Division, Department of Medicine, Education and Research, Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9,, Ireland.
Citation:
Arch Immunol Ther Exp (Warsz). 2011 Apr;59(2):97-112. Epub 2011 Feb 11.
Journal:
Archivum immunologiae et therapiae experimentalis
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207165
DOI:
10.1007/s00005-011-0113-6
PubMed ID:
21311988
Abstract:
Cystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence by killing and digesting phagocytosed bacteria and fungi, yet despite advances in our understanding of the molecular and cellular basis of CF, there remains a paradox of why recruited CF neutrophils fail to eradicate bacterial infections in the lung. This review describes mechanisms involved in neutrophil migration, microbial killing and apoptosis leading to inflammatory resolution. We discuss dysregulated neutrophil activity and consider genetic versus inflammatory neutrophil reprogramming in CF and ultimately pharmacological modulation of the CF neutrophil for therapeutic intervention.
Language:
eng
MeSH:
Animals; Apoptosis; Cell Degranulation; Chemotaxis, Leukocyte; Cystic Fibrosis/genetics/*immunology/metabolism/microbiology/pathology/therapy; Humans; NADPH Oxidase/metabolism; *Neutrophil Activation; Neutrophils/*immunology/metabolism/microbiology/pathology; Phagocytosis; Respiratory Burst
ISSN:
1661-4917 (Electronic); 0004-069X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHayes, Elaineen_GB
dc.contributor.authorPohl, Kerstinen_GB
dc.contributor.authorMcElvaney, Noel Gen_GB
dc.contributor.authorReeves, Emer Pen_GB
dc.date.accessioned2012-02-01T10:00:51Z-
dc.date.available2012-02-01T10:00:51Z-
dc.date.issued2012-02-01T10:00:51Z-
dc.identifier.citationArch Immunol Ther Exp (Warsz). 2011 Apr;59(2):97-112. Epub 2011 Feb 11.en_GB
dc.identifier.issn1661-4917 (Electronic)en_GB
dc.identifier.issn0004-069X (Linking)en_GB
dc.identifier.pmid21311988en_GB
dc.identifier.doi10.1007/s00005-011-0113-6en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207165-
dc.description.abstractCystic fibrosis (CF) is one of the commonest genetically inherited diseases in the world. It is characterized by recurrent respiratory tract infections eventually leading to respiratory failure. One of the hallmarks of this disease is a persistent and predominantly neutrophil driven inflammation. Neutrophils provide the first line of defence by killing and digesting phagocytosed bacteria and fungi, yet despite advances in our understanding of the molecular and cellular basis of CF, there remains a paradox of why recruited CF neutrophils fail to eradicate bacterial infections in the lung. This review describes mechanisms involved in neutrophil migration, microbial killing and apoptosis leading to inflammatory resolution. We discuss dysregulated neutrophil activity and consider genetic versus inflammatory neutrophil reprogramming in CF and ultimately pharmacological modulation of the CF neutrophil for therapeutic intervention.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshApoptosisen_GB
dc.subject.meshCell Degranulationen_GB
dc.subject.meshChemotaxis, Leukocyteen_GB
dc.subject.meshCystic Fibrosis/genetics/*immunology/metabolism/microbiology/pathology/therapyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshNADPH Oxidase/metabolismen_GB
dc.subject.mesh*Neutrophil Activationen_GB
dc.subject.meshNeutrophils/*immunology/metabolism/microbiology/pathologyen_GB
dc.subject.meshPhagocytosisen_GB
dc.subject.meshRespiratory Bursten_GB
dc.titleThe cystic fibrosis neutrophil: a specialized yet potentially defective cell.en_GB
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Education and Research, Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9,, Ireland.en_GB
dc.identifier.journalArchivum immunologiae et therapiae experimentalisen_GB
dc.description.provinceLeinster-

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