The role of secreted frizzled-related protein 2 expression in prostate cancer.

Hdl Handle:
http://hdl.handle.net/10147/207152
Title:
The role of secreted frizzled-related protein 2 expression in prostate cancer.
Authors:
O'Hurley, Gillian; Perry, Antoinette S; O'Grady, Anthony; Loftus, Barbara; Smyth, Paul; O'Leary, John J; Sheils, Orla; Fitzpatrick, John M; Hewitt, Stephen M; Lawler, Mark; Kay, Elaine W
Affiliation:
Department of Pathology, RCSI Education & Research Centre, Royal College of, Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. gillianohurley@rcsi.ie
Citation:
Histopathology. 2011 Dec;59(6):1240-8. doi: 10.1111/j.1365-2559.2011.04073.x.
Journal:
Histopathology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207152
DOI:
10.1111/j.1365-2559.2011.04073.x
PubMed ID:
22175903
Abstract:
AIMS: Improved prostate cancer (PCa)-specific biomarkers are urgently required to distinguish between indolent and aggressive disease, in order to avoid overtreatment. In this study, we investigated the prostatic tissue expression of secreted frizzled-related protein (SFRP)-2. METHODS AND RESULTS: Following immunohistochemical analysis on PCa tissue microarrays with samples from 216 patients, strong/moderate SFRP-2 expression was observed in epithelial cells of benign prostatic hyperplasia, and negative/weak SFRP-2 expression was observed in the majority of tumour epithelia. However, among Gleason grade 5 carcinomas, 40% showed strong/moderate SFRP-2 expression and 60% showed negative SFRP-2 expression in epithelial cells. Further microscopic evaluation of Gleason grade 5 tumours revealed different morphological patterns, corresponding with differential SFRP-2 expression. The first subgroup (referred to as Type A) appeared to have a morphologically solid growth pattern, whereas the second subgroup (referred to as Type B) appeared to have a more diffuse pattern. Furthermore, 100% (4/4) of Type A patients experienced biochemical recurrence, as compared with 0% (0/6) of Type B patients. CONCLUSIONS: These results imply: (i) that there is a loss of SFRP-2 expression from benign to malignant prostate glands; and (ii) differential SFRP-2 expression among two possible subgroups of Gleason grade 5 tumours.
Language:
eng
ISSN:
1365-2559 (Electronic); 0309-0167 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Hurley, Gillianen_GB
dc.contributor.authorPerry, Antoinette Sen_GB
dc.contributor.authorO'Grady, Anthonyen_GB
dc.contributor.authorLoftus, Barbaraen_GB
dc.contributor.authorSmyth, Paulen_GB
dc.contributor.authorO'Leary, John Jen_GB
dc.contributor.authorSheils, Orlaen_GB
dc.contributor.authorFitzpatrick, John Men_GB
dc.contributor.authorHewitt, Stephen Men_GB
dc.contributor.authorLawler, Marken_GB
dc.contributor.authorKay, Elaine Wen_GB
dc.date.accessioned2012-02-01T10:00:30Z-
dc.date.available2012-02-01T10:00:30Z-
dc.date.issued2012-02-01T10:00:30Z-
dc.identifier.citationHistopathology. 2011 Dec;59(6):1240-8. doi: 10.1111/j.1365-2559.2011.04073.x.en_GB
dc.identifier.issn1365-2559 (Electronic)en_GB
dc.identifier.issn0309-0167 (Linking)en_GB
dc.identifier.pmid22175903en_GB
dc.identifier.doi10.1111/j.1365-2559.2011.04073.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207152-
dc.description.abstractAIMS: Improved prostate cancer (PCa)-specific biomarkers are urgently required to distinguish between indolent and aggressive disease, in order to avoid overtreatment. In this study, we investigated the prostatic tissue expression of secreted frizzled-related protein (SFRP)-2. METHODS AND RESULTS: Following immunohistochemical analysis on PCa tissue microarrays with samples from 216 patients, strong/moderate SFRP-2 expression was observed in epithelial cells of benign prostatic hyperplasia, and negative/weak SFRP-2 expression was observed in the majority of tumour epithelia. However, among Gleason grade 5 carcinomas, 40% showed strong/moderate SFRP-2 expression and 60% showed negative SFRP-2 expression in epithelial cells. Further microscopic evaluation of Gleason grade 5 tumours revealed different morphological patterns, corresponding with differential SFRP-2 expression. The first subgroup (referred to as Type A) appeared to have a morphologically solid growth pattern, whereas the second subgroup (referred to as Type B) appeared to have a more diffuse pattern. Furthermore, 100% (4/4) of Type A patients experienced biochemical recurrence, as compared with 0% (0/6) of Type B patients. CONCLUSIONS: These results imply: (i) that there is a loss of SFRP-2 expression from benign to malignant prostate glands; and (ii) differential SFRP-2 expression among two possible subgroups of Gleason grade 5 tumours.en_GB
dc.language.isoengen_GB
dc.titleThe role of secreted frizzled-related protein 2 expression in prostate cancer.en_GB
dc.contributor.departmentDepartment of Pathology, RCSI Education & Research Centre, Royal College of, Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland. gillianohurley@rcsi.ieen_GB
dc.identifier.journalHistopathologyen_GB
dc.description.provinceLeinster-

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