The role of topical antibiotics used as prophylaxis in surgical site infection prevention.

Hdl Handle:
http://hdl.handle.net/10147/207144
Title:
The role of topical antibiotics used as prophylaxis in surgical site infection prevention.
Authors:
McHugh, S M; Collins, C J; Corrigan, M A; Hill, A D K; Humphreys, H
Affiliation:
Department of Surgery, Royal College of Surgeons in Ireland, and Beaumont, Hospital, Dublin, Ireland. seamusmchugh@rcsi.ie
Citation:
J Antimicrob Chemother. 2011 Apr;66(4):693-701. Epub 2011 Feb 3.
Journal:
The Journal of antimicrobial chemotherapy
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207144
DOI:
10.1093/jac/dkr009
PubMed ID:
21393223
Abstract:
Compared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining 'topical' or 'local' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.
Language:
eng
MeSH:
Anti-Infective Agents, Local/*therapeutic use; Antibiotic Prophylaxis/*methods; Humans; Randomized Controlled Trials as Topic; Surgical Wound Infection/*prevention & control; Treatment Outcome
ISSN:
1460-2091 (Electronic); 0305-7453 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcHugh, S Men_GB
dc.contributor.authorCollins, C Jen_GB
dc.contributor.authorCorrigan, M Aen_GB
dc.contributor.authorHill, A D Ken_GB
dc.contributor.authorHumphreys, Hen_GB
dc.date.accessioned2012-02-01T10:00:18Z-
dc.date.available2012-02-01T10:00:18Z-
dc.date.issued2012-02-01T10:00:18Z-
dc.identifier.citationJ Antimicrob Chemother. 2011 Apr;66(4):693-701. Epub 2011 Feb 3.en_GB
dc.identifier.issn1460-2091 (Electronic)en_GB
dc.identifier.issn0305-7453 (Linking)en_GB
dc.identifier.pmid21393223en_GB
dc.identifier.doi10.1093/jac/dkr009en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207144-
dc.description.abstractCompared with systemic antibiotic therapy, the topical or local delivery of an antibiotic has many potential advantages. However, local antibiotics at the surgical site have received very limited approval in any of the surgical prophylaxis consensus guidelines that we are aware of. A review of the literature was carried out through searches of peer-reviewed publications in PubMed in the English language over a 30 year period between January 1980 and May 2010. Both retrospective and prospective studies were included, as well as meta-analyses. With regard to defining 'topical' or 'local' antibiotic application, the application of an antibiotic solution to the surgical site intraoperatively or immediately post-operatively was included. A number of surgical procedures have been shown to significantly benefit from perioperative topical prophylaxis, e.g. joint arthroplasty, cataract surgery and, possibly, breast augmentation. In obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. The selective use of topical antibiotics as surgical prophylaxis is justified for specific procedures, such as joint arthroplasty, cataract surgery and, possibly, breast augmentation. In selective cases, such as obese patients undergoing abdominal surgery, topical surgical prophylaxis is also proven to be beneficial. Apart from these specific indications, the evidence for use of topical antibiotics in surgery is lacking in conclusive randomized controlled trials.en_GB
dc.language.isoengen_GB
dc.subject.meshAnti-Infective Agents, Local/*therapeutic useen_GB
dc.subject.meshAntibiotic Prophylaxis/*methodsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshRandomized Controlled Trials as Topicen_GB
dc.subject.meshSurgical Wound Infection/*prevention & controlen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleThe role of topical antibiotics used as prophylaxis in surgical site infection prevention.en_GB
dc.contributor.departmentDepartment of Surgery, Royal College of Surgeons in Ireland, and Beaumont, Hospital, Dublin, Ireland. seamusmchugh@rcsi.ieen_GB
dc.identifier.journalThe Journal of antimicrobial chemotherapyen_GB
dc.description.provinceLeinster-

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