New insights about vitamin d and cardiovascular disease: a narrative review.

Hdl Handle:
http://hdl.handle.net/10147/207141
Title:
New insights about vitamin d and cardiovascular disease: a narrative review.
Authors:
McGreevy, Cora; Williams, David
Affiliation:
Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Citation:
Ann Intern Med. 2011 Dec 20;155(12):820-6.
Journal:
Annals of internal medicine
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207141
DOI:
10.1059/0003-4819-155-12-201112200-00004
PubMed ID:
22184689
Abstract:
The worsening worldwide trend toward nutritional insufficiency and the emerging knowledge of the nonhormonal actions of vitamin D and its metabolites have increased interest in the synthesis, metabolism, and action of vitamin D. Vitamin D deficiency has been linked with hypertension, myocardial infarction, and stroke, as well as other cardiovascular-related diseases, such as diabetes, congestive heart failure, peripheral vascular disease, atherosclerosis, and endothelial dysfunction. This review discusses the physiology and definition of vitamin D deficiency, evaluates the worldwide prevalence of vitamin D deficiency, and discusses recent evidence for the association between hypovitaminosis D and cardiovascular disease. Few randomized, controlled trials have evaluated the effect of vitamin D replacement on cardiovascular outcomes, and the results have been inconclusive or contradictory. Carefully designed randomized, controlled trials are essential to evaluate the role of vitamin D supplementation in reducing cardiovascular disease.
Language:
eng
ISSN:
1539-3704 (Electronic); 0003-4819 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcGreevy, Coraen_GB
dc.contributor.authorWilliams, Daviden_GB
dc.date.accessioned2012-02-01T10:00:14Z-
dc.date.available2012-02-01T10:00:14Z-
dc.date.issued2012-02-01T10:00:14Z-
dc.identifier.citationAnn Intern Med. 2011 Dec 20;155(12):820-6.en_GB
dc.identifier.issn1539-3704 (Electronic)en_GB
dc.identifier.issn0003-4819 (Linking)en_GB
dc.identifier.pmid22184689en_GB
dc.identifier.doi10.1059/0003-4819-155-12-201112200-00004en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207141-
dc.description.abstractThe worsening worldwide trend toward nutritional insufficiency and the emerging knowledge of the nonhormonal actions of vitamin D and its metabolites have increased interest in the synthesis, metabolism, and action of vitamin D. Vitamin D deficiency has been linked with hypertension, myocardial infarction, and stroke, as well as other cardiovascular-related diseases, such as diabetes, congestive heart failure, peripheral vascular disease, atherosclerosis, and endothelial dysfunction. This review discusses the physiology and definition of vitamin D deficiency, evaluates the worldwide prevalence of vitamin D deficiency, and discusses recent evidence for the association between hypovitaminosis D and cardiovascular disease. Few randomized, controlled trials have evaluated the effect of vitamin D replacement on cardiovascular outcomes, and the results have been inconclusive or contradictory. Carefully designed randomized, controlled trials are essential to evaluate the role of vitamin D supplementation in reducing cardiovascular disease.en_GB
dc.language.isoengen_GB
dc.titleNew insights about vitamin d and cardiovascular disease: a narrative review.en_GB
dc.contributor.departmentRoyal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.en_GB
dc.identifier.journalAnnals of internal medicineen_GB
dc.description.provinceLeinster-

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