The involvement of glycosaminoglycans in airway disease associated with cystic fibrosis.

Hdl Handle:
http://hdl.handle.net/10147/207114
Title:
The involvement of glycosaminoglycans in airway disease associated with cystic fibrosis.
Authors:
Reeves, Emer P; Bergin, David A; Murray, Michelle A; McElvaney, Noel G
Affiliation:
Respiratory Research Division, Department of Medicine, Royal College of Surgeons , in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland., emerreeves@rcsi.ie
Citation:
ScientificWorldJournal. 2011 Apr 19;11:959-71.
Journal:
TheScientificWorldJournal
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207114
DOI:
10.1100/tsw.2011.81
PubMed ID:
21516290
Abstract:
Individuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets.
Language:
eng
MeSH:
Cystic Fibrosis/*complications/immunology/metabolism/microbiology; Extracellular Matrix/metabolism; Glycosaminoglycans/chemistry/*physiology; Humans; Peptide Hydrolases/metabolism; Respiration Disorders/etiology/metabolism/microbiology/pathology; Respiratory System/metabolism/microbiology/physiopathology; Signal Transduction
ISSN:
1537-744X (Electronic); 1537-744X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorReeves, Emer Pen_GB
dc.contributor.authorBergin, David Aen_GB
dc.contributor.authorMurray, Michelle Aen_GB
dc.contributor.authorMcElvaney, Noel Gen_GB
dc.date.accessioned2012-02-01T09:59:34Z-
dc.date.available2012-02-01T09:59:34Z-
dc.date.issued2012-02-01T09:59:34Z-
dc.identifier.citationScientificWorldJournal. 2011 Apr 19;11:959-71.en_GB
dc.identifier.issn1537-744X (Electronic)en_GB
dc.identifier.issn1537-744X (Linking)en_GB
dc.identifier.pmid21516290en_GB
dc.identifier.doi10.1100/tsw.2011.81en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207114-
dc.description.abstractIndividuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets.en_GB
dc.language.isoengen_GB
dc.subject.meshCystic Fibrosis/*complications/immunology/metabolism/microbiologyen_GB
dc.subject.meshExtracellular Matrix/metabolismen_GB
dc.subject.meshGlycosaminoglycans/chemistry/*physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshPeptide Hydrolases/metabolismen_GB
dc.subject.meshRespiration Disorders/etiology/metabolism/microbiology/pathologyen_GB
dc.subject.meshRespiratory System/metabolism/microbiology/physiopathologyen_GB
dc.subject.meshSignal Transductionen_GB
dc.titleThe involvement of glycosaminoglycans in airway disease associated with cystic fibrosis.en_GB
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Royal College of Surgeons , in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland., emerreeves@rcsi.ieen_GB
dc.identifier.journalTheScientificWorldJournalen_GB
dc.description.provinceLeinster-

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