Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable.

Hdl Handle:
http://hdl.handle.net/10147/207111
Title:
Somnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable.
Authors:
Crowley, R K; Woods, C; Fleming, M; Rogers, B; Behan, L A; O'Sullivan, E P; Kane, T; Agha, A; Smith, D; Costello, R W; Thompson, C J
Affiliation:
Department of Academic Endocrinology, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Clin Endocrinol (Oxf). 2011 Jun;74(6):750-5. doi:, 10.1111/j.1365-2265.2011.03993.x.
Journal:
Clinical endocrinology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207111
DOI:
10.1111/j.1365-2265.2011.03993.x
PubMed ID:
21521265
Abstract:
CONTEXT AND OBJECTIVE: Somnolence and obesity are prevalent in craniopharyngioma patients. We hypothesized that somnolence was because of obstructive sleep apnoea in craniopharyngioma patients. DESIGN, PATIENTS AND MEASUREMENTS: We assessed prevalence of somnolence and sleep apnoea in 28 craniopharyngioma and 23 obese controls attending a tertiary referral centre, by means of the Epworth Sleepiness Score (ESS) and polysomnography. All subjects with sleep apnoea were offered continuous positive airway pressure therapy (CPAP) or modafinil. All craniopharyngioma patients, with unexplained somnolence, were offered modafinil. RESULTS: Somnolence was reported by 20/28 (71.5%) craniopharyngioma patients and 4/23 (17%) obese subjects (P < 0.001). Median ESS was 7.5 (IQR 6, 10.7) in craniopharyngioma patients and 4.0 (4,8) in controls, P < 0.01. Eleven somnolent craniopharyngioma patients had obstructive sleep apnoea, in whom treatment led to a reduction in ESS by 6.4 +/- 1.4, P = 0.01. Among the remaining nine patients, five were offered modafinil therapy, of whom four had benefit, three were not compliant with hormone replacement, and one died before intervention. There was no difference in the prevalence of obstructive sleep apnoea between craniopharyngioma (n = 13, 46%) and obese subjects (n = 14, 61%, P = 0.4). Body mass index (BMI) does not correlate with apnoea hypopnoea index [apnoea - hypopnoea index (AHI), r = 0.25, P = 0.08], which suggests that obesity alone does not explain the prevalence of sleep apnoea in craniopharyngioma patients. CONCLUSIONS: Somnolence is common in craniopharyngioma patients and in the majority is because of obstructive sleep apnoea. An additional group of somnolent craniopharyngioma patients benefits from modafinil.
Language:
eng
MeSH:
Adult; Aged; Benzhydryl Compounds/therapeutic use; Central Nervous System Stimulants/therapeutic use; Continuous Positive Airway Pressure; Craniopharyngioma/*complications; Female; Humans; Male; Middle Aged; Pituitary Neoplasms/*complications; Polysomnography; Sleep Apnea Syndromes/complications/*diagnosis/therapy; Sleep Disorders/*diagnosis/etiology/therapy; Treatment Outcome; Young Adult
ISSN:
1365-2265 (Electronic); 0300-0664 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCrowley, R Ken_GB
dc.contributor.authorWoods, Cen_GB
dc.contributor.authorFleming, Men_GB
dc.contributor.authorRogers, Ben_GB
dc.contributor.authorBehan, L Aen_GB
dc.contributor.authorO'Sullivan, E Pen_GB
dc.contributor.authorKane, Ten_GB
dc.contributor.authorAgha, Aen_GB
dc.contributor.authorSmith, Den_GB
dc.contributor.authorCostello, R Wen_GB
dc.contributor.authorThompson, C Jen_GB
dc.date.accessioned2012-02-01T09:59:29Z-
dc.date.available2012-02-01T09:59:29Z-
dc.date.issued2012-02-01T09:59:29Z-
dc.identifier.citationClin Endocrinol (Oxf). 2011 Jun;74(6):750-5. doi:, 10.1111/j.1365-2265.2011.03993.x.en_GB
dc.identifier.issn1365-2265 (Electronic)en_GB
dc.identifier.issn0300-0664 (Linking)en_GB
dc.identifier.pmid21521265en_GB
dc.identifier.doi10.1111/j.1365-2265.2011.03993.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207111-
dc.description.abstractCONTEXT AND OBJECTIVE: Somnolence and obesity are prevalent in craniopharyngioma patients. We hypothesized that somnolence was because of obstructive sleep apnoea in craniopharyngioma patients. DESIGN, PATIENTS AND MEASUREMENTS: We assessed prevalence of somnolence and sleep apnoea in 28 craniopharyngioma and 23 obese controls attending a tertiary referral centre, by means of the Epworth Sleepiness Score (ESS) and polysomnography. All subjects with sleep apnoea were offered continuous positive airway pressure therapy (CPAP) or modafinil. All craniopharyngioma patients, with unexplained somnolence, were offered modafinil. RESULTS: Somnolence was reported by 20/28 (71.5%) craniopharyngioma patients and 4/23 (17%) obese subjects (P < 0.001). Median ESS was 7.5 (IQR 6, 10.7) in craniopharyngioma patients and 4.0 (4,8) in controls, P < 0.01. Eleven somnolent craniopharyngioma patients had obstructive sleep apnoea, in whom treatment led to a reduction in ESS by 6.4 +/- 1.4, P = 0.01. Among the remaining nine patients, five were offered modafinil therapy, of whom four had benefit, three were not compliant with hormone replacement, and one died before intervention. There was no difference in the prevalence of obstructive sleep apnoea between craniopharyngioma (n = 13, 46%) and obese subjects (n = 14, 61%, P = 0.4). Body mass index (BMI) does not correlate with apnoea hypopnoea index [apnoea - hypopnoea index (AHI), r = 0.25, P = 0.08], which suggests that obesity alone does not explain the prevalence of sleep apnoea in craniopharyngioma patients. CONCLUSIONS: Somnolence is common in craniopharyngioma patients and in the majority is because of obstructive sleep apnoea. An additional group of somnolent craniopharyngioma patients benefits from modafinil.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshBenzhydryl Compounds/therapeutic useen_GB
dc.subject.meshCentral Nervous System Stimulants/therapeutic useen_GB
dc.subject.meshContinuous Positive Airway Pressureen_GB
dc.subject.meshCraniopharyngioma/*complicationsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPituitary Neoplasms/*complicationsen_GB
dc.subject.meshPolysomnographyen_GB
dc.subject.meshSleep Apnea Syndromes/complications/*diagnosis/therapyen_GB
dc.subject.meshSleep Disorders/*diagnosis/etiology/therapyen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.subject.meshYoung Adulten_GB
dc.titleSomnolence in adult craniopharyngioma patients is a common, heterogeneous condition that is potentially treatable.en_GB
dc.contributor.departmentDepartment of Academic Endocrinology, Beaumont Hospital, Dublin 9, Ireland.en_GB
dc.identifier.journalClinical endocrinologyen_GB
dc.description.provinceLeinster-

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