In touch with psoriasis: topical treatments and current guidelines.

Hdl Handle:
http://hdl.handle.net/10147/207108
Title:
In touch with psoriasis: topical treatments and current guidelines.
Authors:
Murphy, G; Reich, K
Affiliation:
National Photobiology Unit Beaumont & Mater Hospitals, Dermatology Department,, Beaumont Hospital, Dublin, Ireland. gillianmmurphy@gmail.com
Citation:
J Eur Acad Dermatol Venereol. 2011 Jun;25 Suppl 4:3-8. doi:, 10.1111/j.1468-3083.2011.04059.x.
Journal:
Journal of the European Academy of Dermatology and Venereology : JEADV
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207108
DOI:
10.1111/j.1468-3083.2011.04059.x
PubMed ID:
21507077
Abstract:
This article describes topical therapies and treatment guidelines for psoriasis and is based on a presentation given by the authors at a satellite symposium held during the 19th Congress of the European Academy of Dermatology and Venereology, 6-10 October, 2010, in Gothenburg, Sweden. The highly variable nature of psoriasis and its individual presentation in patients can make it difficult to choose the most appropriate treatment. There are many treatment options, from topical treatment with emollients for very mild psoriasis, to systemic therapy with fumaric acid esters, methotrexate or biologics for severe disease. For the treatment of mild-to-moderate psoriasis, topical therapy is generally the most appropriate and a variety of options, both historical and recent, are available. Newer therapies offer greater convenience and fewer side-effects. Of the more recently available therapies, vitamin D analogues and topical corticosteroids are the two with the greatest proven efficacy in randomized clinical trials. A recent Cochrane review showed the highest efficacy overall with the fixed combination vitamin D analogue (calcipotriol) and corticosteroid (betamethasone dipropionate). Indeed, clinical trials have shown that two-compound calcipotriol/betamethasone dipropionate ointment has higher efficacy than calcipotriol or betamethasone dipropionate alone. With regard to safety, two-compound calcipotriol/betamethasone dipropionate was shown to be suitable for intermittent long-term treatment of mild-to-moderate psoriasis. The findings of the Cochrane review are reflected in the current treatment guidelines from the USA and Germany regarding the treatment of mild-to-moderate psoriasis. In both these guidelines, which will be discussed in this article, the recommended treatments for this patient group are vitamin D analogues and corticosteroids, particularly when used in combination.
Language:
eng
MeSH:
Administration, Topical; Betamethasone/administration & dosage/analogs & derivatives/therapeutic use; Calcitriol/administration & dosage/analogs & derivatives/therapeutic use; Dermatologic Agents/administration & dosage/*therapeutic use; Humans; *Practice Guidelines as Topic; Psoriasis/*drug therapy
ISSN:
1468-3083 (Electronic); 0926-9959 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Gen_GB
dc.contributor.authorReich, Ken_GB
dc.date.accessioned2012-02-01T09:59:25Z-
dc.date.available2012-02-01T09:59:25Z-
dc.date.issued2012-02-01T09:59:25Z-
dc.identifier.citationJ Eur Acad Dermatol Venereol. 2011 Jun;25 Suppl 4:3-8. doi:, 10.1111/j.1468-3083.2011.04059.x.en_GB
dc.identifier.issn1468-3083 (Electronic)en_GB
dc.identifier.issn0926-9959 (Linking)en_GB
dc.identifier.pmid21507077en_GB
dc.identifier.doi10.1111/j.1468-3083.2011.04059.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207108-
dc.description.abstractThis article describes topical therapies and treatment guidelines for psoriasis and is based on a presentation given by the authors at a satellite symposium held during the 19th Congress of the European Academy of Dermatology and Venereology, 6-10 October, 2010, in Gothenburg, Sweden. The highly variable nature of psoriasis and its individual presentation in patients can make it difficult to choose the most appropriate treatment. There are many treatment options, from topical treatment with emollients for very mild psoriasis, to systemic therapy with fumaric acid esters, methotrexate or biologics for severe disease. For the treatment of mild-to-moderate psoriasis, topical therapy is generally the most appropriate and a variety of options, both historical and recent, are available. Newer therapies offer greater convenience and fewer side-effects. Of the more recently available therapies, vitamin D analogues and topical corticosteroids are the two with the greatest proven efficacy in randomized clinical trials. A recent Cochrane review showed the highest efficacy overall with the fixed combination vitamin D analogue (calcipotriol) and corticosteroid (betamethasone dipropionate). Indeed, clinical trials have shown that two-compound calcipotriol/betamethasone dipropionate ointment has higher efficacy than calcipotriol or betamethasone dipropionate alone. With regard to safety, two-compound calcipotriol/betamethasone dipropionate was shown to be suitable for intermittent long-term treatment of mild-to-moderate psoriasis. The findings of the Cochrane review are reflected in the current treatment guidelines from the USA and Germany regarding the treatment of mild-to-moderate psoriasis. In both these guidelines, which will be discussed in this article, the recommended treatments for this patient group are vitamin D analogues and corticosteroids, particularly when used in combination.en_GB
dc.language.isoengen_GB
dc.subject.meshAdministration, Topicalen_GB
dc.subject.meshBetamethasone/administration & dosage/analogs & derivatives/therapeutic useen_GB
dc.subject.meshCalcitriol/administration & dosage/analogs & derivatives/therapeutic useen_GB
dc.subject.meshDermatologic Agents/administration & dosage/*therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Practice Guidelines as Topicen_GB
dc.subject.meshPsoriasis/*drug therapyen_GB
dc.titleIn touch with psoriasis: topical treatments and current guidelines.en_GB
dc.contributor.departmentNational Photobiology Unit Beaumont & Mater Hospitals, Dermatology Department,, Beaumont Hospital, Dublin, Ireland. gillianmmurphy@gmail.comen_GB
dc.identifier.journalJournal of the European Academy of Dermatology and Venereology : JEADVen_GB
dc.description.provinceLeinster-
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