Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.

Hdl Handle:
http://hdl.handle.net/10147/207076
Title:
Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.
Authors:
Low, Teck Boon; Greene, Catherine M; O'Neill, Shane J; McElvaney, Noel G
Affiliation:
Respiratory Research Division, Department of Medicine, Royal College of Surgeons , in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Pulm Med. 2011;2011:826160. Epub 2011 Mar 31.
Journal:
Pulmonary medicine
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207076
DOI:
10.1155/2011/826160
PubMed ID:
21660246
Abstract:
Chronic obstructive pulmonary disease (COPD) may be an autoimmune disease. Smoking causes an imbalance of proteases and antiproteases in the lung resulting in the generation of elastin peptides that can potentially act as autoantigens. Similar to COPD, Z alpha-1 antitrypsin deficiency (Z-A1ATD) and cystic fibrosis (CF) are associated with impaired pulmonary antiprotease defences leading to unopposed protease activity. Here, we show that there is a trend towards higher bronchoalveolar lavage fluid (BALF) antielastin antibody levels in COPD and Z-A1ATD and significantly lower levels in CF compared to control BALF; the lower levels in CF are due to the degradation of these antibodies by neutrophil elastase. We also provide evidence that these autoantibodies have the potential to induce T cell proliferation in the emphysematous lung. This study highlights that antielastin antibodies are tissue specific, can be detected at elevated levels in COPD and Z-A1ATD BALF despite their being no differences in their levels in plasma compared to controls, and suggests a therapeutic role for agents targeting these autoantibodies in the lungs.
Language:
eng
ISSN:
2090-1844 (Electronic); 2090-1844 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLow, Teck Boonen_GB
dc.contributor.authorGreene, Catherine Men_GB
dc.contributor.authorO'Neill, Shane Jen_GB
dc.contributor.authorMcElvaney, Noel Gen_GB
dc.date.accessioned2012-02-01T09:58:39Z-
dc.date.available2012-02-01T09:58:39Z-
dc.date.issued2012-02-01T09:58:39Z-
dc.identifier.citationPulm Med. 2011;2011:826160. Epub 2011 Mar 31.en_GB
dc.identifier.issn2090-1844 (Electronic)en_GB
dc.identifier.issn2090-1844 (Linking)en_GB
dc.identifier.pmid21660246en_GB
dc.identifier.doi10.1155/2011/826160en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207076-
dc.description.abstractChronic obstructive pulmonary disease (COPD) may be an autoimmune disease. Smoking causes an imbalance of proteases and antiproteases in the lung resulting in the generation of elastin peptides that can potentially act as autoantigens. Similar to COPD, Z alpha-1 antitrypsin deficiency (Z-A1ATD) and cystic fibrosis (CF) are associated with impaired pulmonary antiprotease defences leading to unopposed protease activity. Here, we show that there is a trend towards higher bronchoalveolar lavage fluid (BALF) antielastin antibody levels in COPD and Z-A1ATD and significantly lower levels in CF compared to control BALF; the lower levels in CF are due to the degradation of these antibodies by neutrophil elastase. We also provide evidence that these autoantibodies have the potential to induce T cell proliferation in the emphysematous lung. This study highlights that antielastin antibodies are tissue specific, can be detected at elevated levels in COPD and Z-A1ATD BALF despite their being no differences in their levels in plasma compared to controls, and suggests a therapeutic role for agents targeting these autoantibodies in the lungs.en_GB
dc.language.isoengen_GB
dc.titleQuantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung.en_GB
dc.contributor.departmentRespiratory Research Division, Department of Medicine, Royal College of Surgeons , in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.en_GB
dc.identifier.journalPulmonary medicineen_GB
dc.description.provinceLeinster-

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