Mechanism of sphingosine 1-phosphate- and lysophosphatidic Acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.

Hdl Handle:
http://hdl.handle.net/10147/207066
Title:
Mechanism of sphingosine 1-phosphate- and lysophosphatidic Acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.
Authors:
Costello, Richard W; Maloney, Michael; Atiyeh, Mazin; Gleich, Gerald; Walsh, Marie-Therese
Affiliation:
Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, , Dublin 9, Ireland; E-Mails: rcostello@rcsi.ie (R.W.C.); micmaloney@rcsi.ie, (M.M.); matiyeh@rcsi.ie (M.A.).
Citation:
Int J Mol Sci. 2011;12(5):3237-49. Epub 2011 May 17.
Journal:
International journal of molecular sciences
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207066
DOI:
10.3390/ijms12053237
PubMed ID:
21686182
Abstract:
The lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via G-protein coupled receptors S1P(1-5) and LPA(1-3) respectively, and are implicated in allergy. Eosinophils accumulate at innervating cholinergic nerves in asthma and adhere to nerve cells via intercellular adhesion molecule-1 (ICAM-1). IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. The G(i) coupled receptors S1P(1), S1P(3), LPA(1), LPA(2) and LPA(3) were expressed on IMR-32 cells. Both S1P and LPA induced ERK phosphorylation and ERK- and G(i)-dependent up-regulation of ICAM-1 expression, with differing time courses. LPA also induced ERK- and G(i)-dependent up-regulation of the eosinophil chemoattractant, CCL-26. The eosinophil granule protein eosinophil peroxidase (EPO) induced ERK-dependent up-regulation of transcription of S1P(1), LPA(1), LPA(2) and LPA(3), providing the situation whereby eosinophil granule proteins may enhance S1P- and/or LPA- induced eosinophil accumulation at nerve cells in allergic conditions.
Language:
eng
ISSN:
1422-0067 (Electronic); 1422-0067 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCostello, Richard Wen_GB
dc.contributor.authorMaloney, Michaelen_GB
dc.contributor.authorAtiyeh, Mazinen_GB
dc.contributor.authorGleich, Geralden_GB
dc.contributor.authorWalsh, Marie-Thereseen_GB
dc.date.accessioned2012-02-01T09:58:26Z-
dc.date.available2012-02-01T09:58:26Z-
dc.date.issued2012-02-01T09:58:26Z-
dc.identifier.citationInt J Mol Sci. 2011;12(5):3237-49. Epub 2011 May 17.en_GB
dc.identifier.issn1422-0067 (Electronic)en_GB
dc.identifier.issn1422-0067 (Linking)en_GB
dc.identifier.pmid21686182en_GB
dc.identifier.doi10.3390/ijms12053237en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207066-
dc.description.abstractThe lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via G-protein coupled receptors S1P(1-5) and LPA(1-3) respectively, and are implicated in allergy. Eosinophils accumulate at innervating cholinergic nerves in asthma and adhere to nerve cells via intercellular adhesion molecule-1 (ICAM-1). IMR-32 neuroblastoma cells were used as an in vitro cholinergic nerve cell model. The G(i) coupled receptors S1P(1), S1P(3), LPA(1), LPA(2) and LPA(3) were expressed on IMR-32 cells. Both S1P and LPA induced ERK phosphorylation and ERK- and G(i)-dependent up-regulation of ICAM-1 expression, with differing time courses. LPA also induced ERK- and G(i)-dependent up-regulation of the eosinophil chemoattractant, CCL-26. The eosinophil granule protein eosinophil peroxidase (EPO) induced ERK-dependent up-regulation of transcription of S1P(1), LPA(1), LPA(2) and LPA(3), providing the situation whereby eosinophil granule proteins may enhance S1P- and/or LPA- induced eosinophil accumulation at nerve cells in allergic conditions.en_GB
dc.language.isoengen_GB
dc.titleMechanism of sphingosine 1-phosphate- and lysophosphatidic Acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.en_GB
dc.contributor.departmentDepartment of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, , Dublin 9, Ireland; E-Mails: rcostello@rcsi.ie (R.W.C.); micmaloney@rcsi.ie, (M.M.); matiyeh@rcsi.ie (M.A.).en_GB
dc.identifier.journalInternational journal of molecular sciencesen_GB
dc.description.provinceLeinster-
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