Immediate re-transplantation following early kidney transplant thrombosis.

Hdl Handle:
http://hdl.handle.net/10147/207043
Title:
Immediate re-transplantation following early kidney transplant thrombosis.
Authors:
Phelan, Paul J; Magee, Colm; O'Kelly, Patrick; J O'Brien, Frank; Little, Dilly; Conlon, Peter J
Affiliation:
Department of Nephrology, Beaumont Hospital, Dublin, Ireland. paulphel@gmail.com
Citation:
Nephrology (Carlton). 2011 Aug;16(6):607-11. doi:, 10.1111/j.1440-1797.2011.01483.x.
Journal:
Nephrology (Carlton, Vic.)
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207043
DOI:
10.1111/j.1440-1797.2011.01483.x
PubMed ID:
21793989
Abstract:
Allograft thrombosis is a devastating early complication of renal transplantation that ultimately leads to allograft loss. We report here on our experience of nine cases of immediate re-transplantation following early kidney transplant thrombosis at a single centre between January 1990 and June 2009. The mean age was 42.9 years at time of transplant. For seven patients, the allograft thrombosis was their first kidney transplant and seven of the nine cases had a deceased donor transplant. The initial transplants functioned for a mean of 1.67 days and the patients received a second allograft at a mean of 3.1 days after graft failure. All of the re-transplants worked immediately. Four allografts failed after a mean of 52.5 months (2-155 months). Two of these died with a functioning allograft, one failed owing to chronic allograft nephropathy and one owing to persistent acute cellular rejection. The remaining five patients still have a functioning allograft after a mean of 101.8 months (7-187 months). One year allograft and patient survival after re-transplantation were 87.5% and 100% respectively (after 5 years, both were 57%). Immediate re-transplantation following early kidney transplant thrombosis can be a success. It may be considered in selected cases after allograft thrombosis.
Language:
eng
MeSH:
Adult; Aged; Female; Graft Rejection/etiology; Graft Survival; Humans; Immunosuppressive Agents/therapeutic use; Ireland; Kaplan-Meier Estimate; Kidney Transplantation/*adverse effects; Male; Middle Aged; Renal Artery/*surgery; Renal Veins/*surgery; Reoperation; Retrospective Studies; Thrombosis/etiology/*surgery; Time Factors; Treatment Failure; Venous Thrombosis/etiology/*surgery; Young Adult
ISSN:
1440-1797 (Electronic); 1320-5358 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorPhelan, Paul Jen_GB
dc.contributor.authorMagee, Colmen_GB
dc.contributor.authorO'Kelly, Patricken_GB
dc.contributor.authorJ O'Brien, Franken_GB
dc.contributor.authorLittle, Dillyen_GB
dc.contributor.authorConlon, Peter Jen_GB
dc.date.accessioned2012-02-01T09:57:53Z-
dc.date.available2012-02-01T09:57:53Z-
dc.date.issued2012-02-01T09:57:53Z-
dc.identifier.citationNephrology (Carlton). 2011 Aug;16(6):607-11. doi:, 10.1111/j.1440-1797.2011.01483.x.en_GB
dc.identifier.issn1440-1797 (Electronic)en_GB
dc.identifier.issn1320-5358 (Linking)en_GB
dc.identifier.pmid21793989en_GB
dc.identifier.doi10.1111/j.1440-1797.2011.01483.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207043-
dc.description.abstractAllograft thrombosis is a devastating early complication of renal transplantation that ultimately leads to allograft loss. We report here on our experience of nine cases of immediate re-transplantation following early kidney transplant thrombosis at a single centre between January 1990 and June 2009. The mean age was 42.9 years at time of transplant. For seven patients, the allograft thrombosis was their first kidney transplant and seven of the nine cases had a deceased donor transplant. The initial transplants functioned for a mean of 1.67 days and the patients received a second allograft at a mean of 3.1 days after graft failure. All of the re-transplants worked immediately. Four allografts failed after a mean of 52.5 months (2-155 months). Two of these died with a functioning allograft, one failed owing to chronic allograft nephropathy and one owing to persistent acute cellular rejection. The remaining five patients still have a functioning allograft after a mean of 101.8 months (7-187 months). One year allograft and patient survival after re-transplantation were 87.5% and 100% respectively (after 5 years, both were 57%). Immediate re-transplantation following early kidney transplant thrombosis can be a success. It may be considered in selected cases after allograft thrombosis.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGraft Rejection/etiologyen_GB
dc.subject.meshGraft Survivalen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunosuppressive Agents/therapeutic useen_GB
dc.subject.meshIrelanden_GB
dc.subject.meshKaplan-Meier Estimateen_GB
dc.subject.meshKidney Transplantation/*adverse effectsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRenal Artery/*surgeryen_GB
dc.subject.meshRenal Veins/*surgeryen_GB
dc.subject.meshReoperationen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshThrombosis/etiology/*surgeryen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshTreatment Failureen_GB
dc.subject.meshVenous Thrombosis/etiology/*surgeryen_GB
dc.subject.meshYoung Adulten_GB
dc.titleImmediate re-transplantation following early kidney transplant thrombosis.en_GB
dc.contributor.departmentDepartment of Nephrology, Beaumont Hospital, Dublin, Ireland. paulphel@gmail.comen_GB
dc.identifier.journalNephrology (Carlton, Vic.)en_GB
dc.description.provinceLeinster-

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