Non-genomic actions of aldosterone: From receptors and signals to membrane targets.

Hdl Handle:
http://hdl.handle.net/10147/207039
Title:
Non-genomic actions of aldosterone: From receptors and signals to membrane targets.
Affiliation:
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education, and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
Citation:
Mol Cell Endocrinol. 2011 Jul 27.
Journal:
Molecular and cellular endocrinology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207039
DOI:
10.1016/j.mce.2011.07.019
PubMed ID:
21801805
Abstract:
In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.
Language:
ENG
ISSN:
1872-8057 (Electronic); 0303-7207 (Linking)

Full metadata record

DC FieldValue Language
dc.date.accessioned2012-02-01T09:57:48Z-
dc.date.available2012-02-01T09:57:48Z-
dc.date.issued2012-02-01T09:57:48Z-
dc.identifier.citationMol Cell Endocrinol. 2011 Jul 27.en_GB
dc.identifier.issn1872-8057 (Electronic)en_GB
dc.identifier.issn0303-7207 (Linking)en_GB
dc.identifier.pmid21801805en_GB
dc.identifier.doi10.1016/j.mce.2011.07.019en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207039-
dc.description.abstractIn tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.en_GB
dc.language.isoENGen_GB
dc.titleNon-genomic actions of aldosterone: From receptors and signals to membrane targets.en_GB
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education, and Research Centre, Beaumont Hospital, Dublin 9, Ireland.en_GB
dc.identifier.journalMolecular and cellular endocrinologyen_GB
dc.description.provinceLeinster-

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