Organising pneumonia associated with fumaric acid ester treatment for psoriasis.

Hdl Handle:
http://hdl.handle.net/10147/207025
Title:
Organising pneumonia associated with fumaric acid ester treatment for psoriasis.
Authors:
Deegan, Alexander Paul; Kirby, Brian; Rogers, Sarah; Crotty, Tom Bernard; McDonnell, Timonthy John
Affiliation:
St. Vincent's University Hospital, Respiratory Department, Dublin, Ireland.
Citation:
Clin Respir J. 2010 Oct;4(4):248-51. doi: 10.1111/j.1752-699X.2009.00180.x.
Journal:
The clinical respiratory journal
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207025
DOI:
10.1111/j.1752-699X.2009.00180.x
PubMed ID:
20887349
Abstract:
INTRODUCTION: We present the case of a 49-year old male who presented with dyspnoea, cough, weight loss, night sweats and general malaise. He had been on treatment with oral fumaric acid esters (FAE, Fumaderm(R); Biogen Idec GmbH, Ismaning, Germany) for 6 months. METHODS: Report of a case. RESULTS: His chest X-ray showed patchy infiltrates in the left upper lobe which failed to resolve under empiric antibiotic therapy. A computed tomography of thorax revealed bilateral, mostly peripheral foci of consolidation with air bronchograms. Transbronchial biopsies showed a pattern of organising pneumonia (OP). CONCLUSIONS: Therapy with oral prednisolone (40 mg/day) resulted in a rapid clinical and radiological improvement. An association of FAE and OP has not previously been reported. Please cite this paper as: Deegan AP, Kirby B, Rogers S, Crotty TB and McDonnell TJ. Organising pneumonia associated with fumaric acid ester treatment for psoriasis.
Language:
eng
MeSH:
Administration, Oral; Biopsy; Cryptogenic Organizing Pneumonia/diagnosis/drug therapy/*etiology; Fumarates/administration & dosage/*adverse effects; Glucocorticoids/therapeutic use; Humans; Lung Diseases/*chemically induced/diagnosis/drug therapy; Male; Middle Aged; Prednisolone/therapeutic use; Psoriasis/*drug therapy; Tomography, X-Ray Computed
ISSN:
1752-699X (Electronic); 1752-6981 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDeegan, Alexander Paulen_GB
dc.contributor.authorKirby, Brianen_GB
dc.contributor.authorRogers, Sarahen_GB
dc.contributor.authorCrotty, Tom Bernarden_GB
dc.contributor.authorMcDonnell, Timonthy Johnen_GB
dc.date.accessioned2012-02-01T10:28:34Z-
dc.date.available2012-02-01T10:28:34Z-
dc.date.issued2012-02-01T10:28:34Z-
dc.identifier.citationClin Respir J. 2010 Oct;4(4):248-51. doi: 10.1111/j.1752-699X.2009.00180.x.en_GB
dc.identifier.issn1752-699X (Electronic)en_GB
dc.identifier.issn1752-6981 (Linking)en_GB
dc.identifier.pmid20887349en_GB
dc.identifier.doi10.1111/j.1752-699X.2009.00180.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207025-
dc.description.abstractINTRODUCTION: We present the case of a 49-year old male who presented with dyspnoea, cough, weight loss, night sweats and general malaise. He had been on treatment with oral fumaric acid esters (FAE, Fumaderm(R); Biogen Idec GmbH, Ismaning, Germany) for 6 months. METHODS: Report of a case. RESULTS: His chest X-ray showed patchy infiltrates in the left upper lobe which failed to resolve under empiric antibiotic therapy. A computed tomography of thorax revealed bilateral, mostly peripheral foci of consolidation with air bronchograms. Transbronchial biopsies showed a pattern of organising pneumonia (OP). CONCLUSIONS: Therapy with oral prednisolone (40 mg/day) resulted in a rapid clinical and radiological improvement. An association of FAE and OP has not previously been reported. Please cite this paper as: Deegan AP, Kirby B, Rogers S, Crotty TB and McDonnell TJ. Organising pneumonia associated with fumaric acid ester treatment for psoriasis.en_GB
dc.language.isoengen_GB
dc.subject.meshAdministration, Oralen_GB
dc.subject.meshBiopsyen_GB
dc.subject.meshCryptogenic Organizing Pneumonia/diagnosis/drug therapy/*etiologyen_GB
dc.subject.meshFumarates/administration & dosage/*adverse effectsen_GB
dc.subject.meshGlucocorticoids/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLung Diseases/*chemically induced/diagnosis/drug therapyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPrednisolone/therapeutic useen_GB
dc.subject.meshPsoriasis/*drug therapyen_GB
dc.subject.meshTomography, X-Ray Computeden_GB
dc.titleOrganising pneumonia associated with fumaric acid ester treatment for psoriasis.en_GB
dc.contributor.departmentSt. Vincent's University Hospital, Respiratory Department, Dublin, Ireland.en_GB
dc.identifier.journalThe clinical respiratory journalen_GB
dc.description.provinceLeinster-

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