A progressive multifocal neurological syndrome in a 42-year-old woman.

Hdl Handle:
http://hdl.handle.net/10147/207007
Title:
A progressive multifocal neurological syndrome in a 42-year-old woman.
Authors:
Cryan, Jane; Brett, Francesca M
Affiliation:
Department of Neuropathology, Beaumont Hospital, Dublin, Ireland.
Citation:
Brain Pathol. 2011 Sep;21(5):611-4. doi: 10.1111/j.1750-3639.2011.00522.x.
Journal:
Brain pathology (Zurich, Switzerland)
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207007
DOI:
10.1111/j.1750-3639.2011.00522.x
PubMed ID:
21854478
Abstract:
This is the case of a 42-year-old female who presented with transient dizziness. Her symptoms and signs progressed to include dysarthria, ataxia and cognitive decline over 2 years, such that she was unable to care for herself. She died 4 years after first presentation without a diagnosis. Investigations revealed a normochromic normocytic anaemia. Cerebrospinal fluid was normal. Serial computed tomography brain showed a wedge-shaped frontal infarct but no progressive changes. Examination at autopsy showed discoloration of the gray and white matter of the brain and spinal cord.Microscopy of leptomeningeal and parenchymal vessels showed they were filled with atypical B lymphocytes confined to the intravascular space with multiple infarcts in the brain, cerebellum and spinal cord. A diagnosis of intravascular B cell lymphoma was made and is discussed.
Language:
eng
MeSH:
Adult; Antigens, CD/metabolism; Autopsy; Cognition Disorders/etiology; Female; Humans; Lymphoma, B-Cell/pathology; Magnetic Resonance Imaging; Nervous System Diseases/complications/*pathology/*physiopathology
ISSN:
1750-3639 (Electronic); 1015-6305 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCryan, Janeen_GB
dc.contributor.authorBrett, Francesca Men_GB
dc.date.accessioned2012-02-01T09:57:29Z-
dc.date.available2012-02-01T09:57:29Z-
dc.date.issued2012-02-01T09:57:29Z-
dc.identifier.citationBrain Pathol. 2011 Sep;21(5):611-4. doi: 10.1111/j.1750-3639.2011.00522.x.en_GB
dc.identifier.issn1750-3639 (Electronic)en_GB
dc.identifier.issn1015-6305 (Linking)en_GB
dc.identifier.pmid21854478en_GB
dc.identifier.doi10.1111/j.1750-3639.2011.00522.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207007-
dc.description.abstractThis is the case of a 42-year-old female who presented with transient dizziness. Her symptoms and signs progressed to include dysarthria, ataxia and cognitive decline over 2 years, such that she was unable to care for herself. She died 4 years after first presentation without a diagnosis. Investigations revealed a normochromic normocytic anaemia. Cerebrospinal fluid was normal. Serial computed tomography brain showed a wedge-shaped frontal infarct but no progressive changes. Examination at autopsy showed discoloration of the gray and white matter of the brain and spinal cord.Microscopy of leptomeningeal and parenchymal vessels showed they were filled with atypical B lymphocytes confined to the intravascular space with multiple infarcts in the brain, cerebellum and spinal cord. A diagnosis of intravascular B cell lymphoma was made and is discussed.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAntigens, CD/metabolismen_GB
dc.subject.meshAutopsyen_GB
dc.subject.meshCognition Disorders/etiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLymphoma, B-Cell/pathologyen_GB
dc.subject.meshMagnetic Resonance Imagingen_GB
dc.subject.meshNervous System Diseases/complications/*pathology/*physiopathologyen_GB
dc.titleA progressive multifocal neurological syndrome in a 42-year-old woman.en_GB
dc.contributor.departmentDepartment of Neuropathology, Beaumont Hospital, Dublin, Ireland.en_GB
dc.identifier.journalBrain pathology (Zurich, Switzerland)en_GB
dc.description.provinceLeinster-

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