High fetal plasma adenosine concentration: a role for the fetus in preeclampsia?

Hdl Handle:
http://hdl.handle.net/10147/207005
Title:
High fetal plasma adenosine concentration: a role for the fetus in preeclampsia?
Authors:
Espinoza, Jimmy; Espinoza, Andres F; Power, Gordon G
Affiliation:
Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, Michigan and Oakland University, Rochester, MI, USA. jimmy.espinoza@beaumont
Citation:
Am J Obstet Gynecol. 2011 Nov;205(5):485.e24-7. Epub 2011 Jun 15.
Journal:
American journal of obstetrics and gynecology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207005
DOI:
10.1016/j.ajog.2011.06.034
PubMed ID:
21855848
Abstract:
OBJECTIVE: Clinical observations suggest a role for the fetus in the maternal manifestations of preeclampsia, but the possible signaling mechanisms remain unclear. This study compares the fetal plasma concentrations of adenosine from normal pregnancies with those from preeclampsia. STUDY DESIGN: This secondary data analysis included normal pregnancies (n = 27) and patients with preeclampsia (n = 39). Patients with preeclampsia were subclassified into patients with (n = 25) and without (n = 14) abnormal uterine artery Doppler velocimetry (UADV). RESULTS: Fetal plasma concentrations of adenosine were significantly higher in patients with preeclampsia (1.35 +/- 0.09 mumol/L) than in normal pregnancies (0.52 +/- 0.06 mumol/L; P < .0001). Fetal plasma concentrations of adenosine in patients with preeclampsia with abnormal UADV (1.78 +/- 0.15 mumol/L), but not with normal UADV (0.58 +/- 0.14 mumol/L), were significantly higher than in normal pregnancies (P < .0001). CONCLUSION: Patients with preeclampsia with sonographic evidence of chronic uteroplacental ischemia have high fetal plasma concentrations of adenosine.
Language:
eng
MeSH:
Adenosine/*blood; Adult; Female; Fetal Blood/*metabolism; Humans; Pre-Eclampsia/blood/*etiology; Pregnancy; Uterine Artery
ISSN:
1097-6868 (Electronic); 0002-9378 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorEspinoza, Jimmyen_GB
dc.contributor.authorEspinoza, Andres Fen_GB
dc.contributor.authorPower, Gordon Gen_GB
dc.date.accessioned2012-02-01T09:57:27Z-
dc.date.available2012-02-01T09:57:27Z-
dc.date.issued2012-02-01T09:57:27Z-
dc.identifier.citationAm J Obstet Gynecol. 2011 Nov;205(5):485.e24-7. Epub 2011 Jun 15.en_GB
dc.identifier.issn1097-6868 (Electronic)en_GB
dc.identifier.issn0002-9378 (Linking)en_GB
dc.identifier.pmid21855848en_GB
dc.identifier.doi10.1016/j.ajog.2011.06.034en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207005-
dc.description.abstractOBJECTIVE: Clinical observations suggest a role for the fetus in the maternal manifestations of preeclampsia, but the possible signaling mechanisms remain unclear. This study compares the fetal plasma concentrations of adenosine from normal pregnancies with those from preeclampsia. STUDY DESIGN: This secondary data analysis included normal pregnancies (n = 27) and patients with preeclampsia (n = 39). Patients with preeclampsia were subclassified into patients with (n = 25) and without (n = 14) abnormal uterine artery Doppler velocimetry (UADV). RESULTS: Fetal plasma concentrations of adenosine were significantly higher in patients with preeclampsia (1.35 +/- 0.09 mumol/L) than in normal pregnancies (0.52 +/- 0.06 mumol/L; P < .0001). Fetal plasma concentrations of adenosine in patients with preeclampsia with abnormal UADV (1.78 +/- 0.15 mumol/L), but not with normal UADV (0.58 +/- 0.14 mumol/L), were significantly higher than in normal pregnancies (P < .0001). CONCLUSION: Patients with preeclampsia with sonographic evidence of chronic uteroplacental ischemia have high fetal plasma concentrations of adenosine.en_GB
dc.language.isoengen_GB
dc.subject.meshAdenosine/*blooden_GB
dc.subject.meshAdulten_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFetal Blood/*metabolismen_GB
dc.subject.meshHumansen_GB
dc.subject.meshPre-Eclampsia/blood/*etiologyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshUterine Arteryen_GB
dc.titleHigh fetal plasma adenosine concentration: a role for the fetus in preeclampsia?en_GB
dc.contributor.departmentDepartment of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, Michigan and Oakland University, Rochester, MI, USA. jimmy.espinoza@beaumonten_GB
dc.identifier.journalAmerican journal of obstetrics and gynecologyen_GB
dc.description.provinceLeinster-

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