B-type natriuretic peptide as predictor of heart failure in patients with acute ST elevation myocardial infarction, single-vessel disease, and complete revascularization: follow-up study.

Hdl Handle:
http://hdl.handle.net/10147/206385
Title:
B-type natriuretic peptide as predictor of heart failure in patients with acute ST elevation myocardial infarction, single-vessel disease, and complete revascularization: follow-up study.
Authors:
Manola, Sime; Pavlovic, Nikola; Radeljic, Vjekoslav; Delic Brkljacic, Diana; Pintaric, Hrvoje; Stambuk, Kresimir; Bulj, Nikola; Trbusic, Matias; Krcmar, Tomislav; Lukinac, Ljerka
Affiliation:
Departmet of Cardiology, Sisters of Mercy University Hospital, Zagreb, Croatia.
Citation:
Croat Med J. 2009 Oct;50(5):449-54.
Journal:
Croatian medical journal
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206385
PubMed ID:
19839068
Abstract:
AIM: To assess the concentration of B-type natriuretic peptide (BNP) as a predictor of heart failure in patients with acute ST elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) with successful and complete revascularization. METHODS: Out of a total of 220 patients with acute STEMI admitted to the Sisters of Mercy University Hospital in the period January 1 to December 31, 2007, only patients with acute STEMI undergoing primary PCI who had single vessel disease and were successfully revascularized were included in the study. Selected patients had no history of myocardial infarction or heart failure and a normal or near-normal left ventricular ejection fraction (> or =50%) assessed by left ventriculography at admission. Only 58 patients met the inclusion criteria for the study. Out of those, 6 patients refused to participate in the study, and another 5 could not be followed up, so a total of 47 patients were evaluated. Blood samples were taken for measurement of BNP levels at admission, 24 hours later, and 7 days later. Patients were followed up for 1 year. The primary outcome was reduction in left ventricular ejection fraction (LVEF) to <50% after 1 year. RESULTS: Patients who developed echocardiographic signs of reduced systolic function defined as LVEF<50% had significantly higher values of BNP (> or =80 pg/mL) at 24 hours (P=0.001) and 7 days (P=0.020) after STEMI and successful reperfusion. Patients who had BNP levels > or =80 pg/mL after 7 days were 21 times more likely to develop LVEF<50 (odds ratio, 20.8; 95% confidence interval, 2.2-195.2; P=0.008). CONCLUSION: BNP can be used as a predictor of reduced systolic function in patients with STEMI who underwent successful reperfusion and had normal ejection fraction at admission.
Language:
eng
MeSH:
*Angioplasty, Balloon, Coronary; Biological Markers/blood; Croatia; Female; Follow-Up Studies; Heart Failure, Systolic/*blood/diagnosis; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction/*blood/diagnosis/therapy; Natriuretic Peptide, Brain/*blood; Predictive Value of Tests; Prognosis; ROC Curve; Ventricular Dysfunction, Left/blood/diagnosis
ISSN:
1332-8166 (Electronic); 0353-9504 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorManola, Simeen_GB
dc.contributor.authorPavlovic, Nikolaen_GB
dc.contributor.authorRadeljic, Vjekoslaven_GB
dc.contributor.authorDelic Brkljacic, Dianaen_GB
dc.contributor.authorPintaric, Hrvojeen_GB
dc.contributor.authorStambuk, Kresimiren_GB
dc.contributor.authorBulj, Nikolaen_GB
dc.contributor.authorTrbusic, Matiasen_GB
dc.contributor.authorKrcmar, Tomislaven_GB
dc.contributor.authorLukinac, Ljerkaen_GB
dc.date.accessioned2012-01-31T16:39:20Z-
dc.date.available2012-01-31T16:39:20Z-
dc.date.issued2012-01-31T16:39:20Z-
dc.identifier.citationCroat Med J. 2009 Oct;50(5):449-54.en_GB
dc.identifier.issn1332-8166 (Electronic)en_GB
dc.identifier.issn0353-9504 (Linking)en_GB
dc.identifier.pmid19839068en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206385-
dc.description.abstractAIM: To assess the concentration of B-type natriuretic peptide (BNP) as a predictor of heart failure in patients with acute ST elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI) with successful and complete revascularization. METHODS: Out of a total of 220 patients with acute STEMI admitted to the Sisters of Mercy University Hospital in the period January 1 to December 31, 2007, only patients with acute STEMI undergoing primary PCI who had single vessel disease and were successfully revascularized were included in the study. Selected patients had no history of myocardial infarction or heart failure and a normal or near-normal left ventricular ejection fraction (> or =50%) assessed by left ventriculography at admission. Only 58 patients met the inclusion criteria for the study. Out of those, 6 patients refused to participate in the study, and another 5 could not be followed up, so a total of 47 patients were evaluated. Blood samples were taken for measurement of BNP levels at admission, 24 hours later, and 7 days later. Patients were followed up for 1 year. The primary outcome was reduction in left ventricular ejection fraction (LVEF) to <50% after 1 year. RESULTS: Patients who developed echocardiographic signs of reduced systolic function defined as LVEF<50% had significantly higher values of BNP (> or =80 pg/mL) at 24 hours (P=0.001) and 7 days (P=0.020) after STEMI and successful reperfusion. Patients who had BNP levels > or =80 pg/mL after 7 days were 21 times more likely to develop LVEF<50 (odds ratio, 20.8; 95% confidence interval, 2.2-195.2; P=0.008). CONCLUSION: BNP can be used as a predictor of reduced systolic function in patients with STEMI who underwent successful reperfusion and had normal ejection fraction at admission.en_GB
dc.language.isoengen_GB
dc.subject.mesh*Angioplasty, Balloon, Coronaryen_GB
dc.subject.meshBiological Markers/blooden_GB
dc.subject.meshCroatiaen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFollow-Up Studiesen_GB
dc.subject.meshHeart Failure, Systolic/*blood/diagnosisen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLogistic Modelsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMyocardial Infarction/*blood/diagnosis/therapyen_GB
dc.subject.meshNatriuretic Peptide, Brain/*blooden_GB
dc.subject.meshPredictive Value of Testsen_GB
dc.subject.meshPrognosisen_GB
dc.subject.meshROC Curveen_GB
dc.subject.meshVentricular Dysfunction, Left/blood/diagnosisen_GB
dc.titleB-type natriuretic peptide as predictor of heart failure in patients with acute ST elevation myocardial infarction, single-vessel disease, and complete revascularization: follow-up study.en_GB
dc.contributor.departmentDepartmet of Cardiology, Sisters of Mercy University Hospital, Zagreb, Croatia.en_GB
dc.identifier.journalCroatian medical journalen_GB
dc.description.provinceMunster-

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