Characteristics of patients presenting with erythema nodosum and sarcoidosis.

Hdl Handle:
http://hdl.handle.net/10147/206369
Title:
Characteristics of patients presenting with erythema nodosum and sarcoidosis.
Authors:
O'Connor, T M; Cagney, D; Jahangir, A; Brady, A; Fitzgibbon, J; Lee, G; El-Gammal, A; Brennan, N J
Affiliation:
Department of Respiratory Medicine, Mercy University Hospital, Cork., terryoconnor@eircom.net
Citation:
Ir Med J. 2009 Jun;102(6):181-4.
Journal:
Irish medical journal
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206369
PubMed ID:
19722355
Abstract:
We explored the relationship between erythema nodosum (EN) and sex, age, serum angiotensin converting enzyme (ACE), bronchoalveolar lavage lymphocytosis (BAL-I), interstitial granulomas and radiological stage in patients presenting with pulmonary sarcoidosis in Ireland. Sixty-nine patients diagnosed with sarcoidosis between 2003 and 2006 were studied. Forty one patients (59%) were male. Sixteen patients (23%) presented with EN. Forty one patients of 65 (63%) had transbronchial biopsies demonstrating non-caseating granulomas. Patients with sarcoidosis presenting with EN were more likely to be female (p=0.042), younger (p=0.012) and have earlier stage pulmonary disease (p=0.02). There were no correlations between serum ACE, interstitial granulomas and disease stage. BAL-I did however predict increasing disease radiological stage (p=0.042). In this study, one quarter of patients with sarcoidosis presented with EN among their presenting features. These patients were more likely to be young females with early stage radiological disease.
Language:
eng
MeSH:
Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Bronchoalveolar Lavage Fluid/*chemistry/cytology; Erythema Nodosum/epidemiology/*radiography; Female; Granuloma/epidemiology/pathology; Humans; Ireland/epidemiology; Lymphocytosis/epidemiology/*radiography; Male; Middle Aged; Peptidyl-Dipeptidase A/*blood; Retrospective Studies; Risk Factors; Sarcoidosis, Pulmonary/epidemiology/pathology/*radiography; Statistics as Topic; Young Adult
ISSN:
0332-3102 (Print); 0332-3102 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connor, T Men_GB
dc.contributor.authorCagney, Den_GB
dc.contributor.authorJahangir, Aen_GB
dc.contributor.authorBrady, Aen_GB
dc.contributor.authorFitzgibbon, Jen_GB
dc.contributor.authorLee, Gen_GB
dc.contributor.authorEl-Gammal, Aen_GB
dc.contributor.authorBrennan, N Jen_GB
dc.date.accessioned2012-01-31T16:39:10Z-
dc.date.available2012-01-31T16:39:10Z-
dc.date.issued2012-01-31T16:39:10Z-
dc.identifier.citationIr Med J. 2009 Jun;102(6):181-4.en_GB
dc.identifier.issn0332-3102 (Print)en_GB
dc.identifier.issn0332-3102 (Linking)en_GB
dc.identifier.pmid19722355en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206369-
dc.description.abstractWe explored the relationship between erythema nodosum (EN) and sex, age, serum angiotensin converting enzyme (ACE), bronchoalveolar lavage lymphocytosis (BAL-I), interstitial granulomas and radiological stage in patients presenting with pulmonary sarcoidosis in Ireland. Sixty-nine patients diagnosed with sarcoidosis between 2003 and 2006 were studied. Forty one patients (59%) were male. Sixteen patients (23%) presented with EN. Forty one patients of 65 (63%) had transbronchial biopsies demonstrating non-caseating granulomas. Patients with sarcoidosis presenting with EN were more likely to be female (p=0.042), younger (p=0.012) and have earlier stage pulmonary disease (p=0.02). There were no correlations between serum ACE, interstitial granulomas and disease stage. BAL-I did however predict increasing disease radiological stage (p=0.042). In this study, one quarter of patients with sarcoidosis presented with EN among their presenting features. These patients were more likely to be young females with early stage radiological disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAge Distributionen_GB
dc.subject.meshAge Factorsen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshBronchoalveolar Lavage Fluid/*chemistry/cytologyen_GB
dc.subject.meshErythema Nodosum/epidemiology/*radiographyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGranuloma/epidemiology/pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshLymphocytosis/epidemiology/*radiographyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPeptidyl-Dipeptidase A/*blooden_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSarcoidosis, Pulmonary/epidemiology/pathology/*radiographyen_GB
dc.subject.meshStatistics as Topicen_GB
dc.subject.meshYoung Adulten_GB
dc.titleCharacteristics of patients presenting with erythema nodosum and sarcoidosis.en_GB
dc.contributor.departmentDepartment of Respiratory Medicine, Mercy University Hospital, Cork., terryoconnor@eircom.neten_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceMunster-

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