Bacteria as vectors for gene therapy of cancer.

Hdl Handle:
http://hdl.handle.net/10147/206366
Title:
Bacteria as vectors for gene therapy of cancer.
Authors:
Baban, Chwanrow K; Cronin, Michelle; O'Hanlon, Deirdre; O'Sullivan, Gerald C; Tangney, Mark
Affiliation:
Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr., Laboratory, University College Cork, Cork, Ireland.
Citation:
Bioeng Bugs. 2010 Nov-Dec;1(6):385-94.
Journal:
Bioengineered bugs
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206366
DOI:
10.4161/bbug.1.6.13146
PubMed ID:
21468205
Abstract:
Anti-cancer therapy faces major challenges, particularly in terms of specificity of treatment. The ideal therapy would eradicate tumor cells selectively with minimum side effects on normal tissue. Gene or cell therapies have emerged as realistic prospects for the treatment of cancer, and involve the delivery of genetic information to a tumor to facilitate the production of therapeutic proteins. However, there is still much to be done before an efficient and safe gene medicine is achieved, primarily developing the means of targeting genes to tumors safely and efficiently. An emerging family of vectors involves bacteria of various genera. It has been shown that bacteria are naturally capable of homing to tumors when systemically administered resulting in high levels of replication locally. Furthermore, invasive species can deliver heterologous genes intra-cellularly for tumor cell expression. Here, we review the use of bacteria as vehicles for gene therapy of cancer, detailing the mechanisms of action and successes at preclinical and clinical levels.
Language:
eng
MeSH:
Animals; Bacteria/*genetics/growth & development; Bacterial Physiological Phenomena; Gene Therapy/*methods; Gene Transfer Techniques; *Genetic Vectors; Humans; Mice; Neoplasms/*therapy
ISSN:
1949-1026 (Electronic); 1949-1018 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorBaban, Chwanrow Ken_GB
dc.contributor.authorCronin, Michelleen_GB
dc.contributor.authorO'Hanlon, Deirdreen_GB
dc.contributor.authorO'Sullivan, Gerald Cen_GB
dc.contributor.authorTangney, Marken_GB
dc.date.accessioned2012-01-31T16:39:58Z-
dc.date.available2012-01-31T16:39:58Z-
dc.date.issued2012-01-31T16:39:58Z-
dc.identifier.citationBioeng Bugs. 2010 Nov-Dec;1(6):385-94.en_GB
dc.identifier.issn1949-1026 (Electronic)en_GB
dc.identifier.issn1949-1018 (Linking)en_GB
dc.identifier.pmid21468205en_GB
dc.identifier.doi10.4161/bbug.1.6.13146en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206366-
dc.description.abstractAnti-cancer therapy faces major challenges, particularly in terms of specificity of treatment. The ideal therapy would eradicate tumor cells selectively with minimum side effects on normal tissue. Gene or cell therapies have emerged as realistic prospects for the treatment of cancer, and involve the delivery of genetic information to a tumor to facilitate the production of therapeutic proteins. However, there is still much to be done before an efficient and safe gene medicine is achieved, primarily developing the means of targeting genes to tumors safely and efficiently. An emerging family of vectors involves bacteria of various genera. It has been shown that bacteria are naturally capable of homing to tumors when systemically administered resulting in high levels of replication locally. Furthermore, invasive species can deliver heterologous genes intra-cellularly for tumor cell expression. Here, we review the use of bacteria as vehicles for gene therapy of cancer, detailing the mechanisms of action and successes at preclinical and clinical levels.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshBacteria/*genetics/growth & developmenten_GB
dc.subject.meshBacterial Physiological Phenomenaen_GB
dc.subject.meshGene Therapy/*methodsen_GB
dc.subject.meshGene Transfer Techniquesen_GB
dc.subject.mesh*Genetic Vectorsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMiceen_GB
dc.subject.meshNeoplasms/*therapyen_GB
dc.titleBacteria as vectors for gene therapy of cancer.en_GB
dc.contributor.departmentCork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jr., Laboratory, University College Cork, Cork, Ireland.en_GB
dc.identifier.journalBioengineered bugsen_GB
dc.description.provinceMunster-

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