Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone.

Hdl Handle:
http://hdl.handle.net/10147/206350
Title:
Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone.
Authors:
Saidha, S; Mok, T H; Butler, M; Fanning, N; Harrington, H
Affiliation:
Department of Neurology, Mercy University Hospital, Grenville Place, Cork,, Ireland. shivsaidha@physicians.ie <shivsaidha@physicians.ie>
Citation:
J Clin Neurosci. 2010 May;17(5):654-5. Epub 2010 Mar 9.
Journal:
Journal of clinical neuroscience : official journal of the Neurosurgical Society , of Australasia
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206350
DOI:
10.1016/j.jocn.2009.09.026
PubMed ID:
20219377
Abstract:
Parkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon beta1a.
Language:
eng
MeSH:
Disease Progression; Glucocorticoids/therapeutic use; Humans; Magnetic Resonance Imaging; Male; Methylprednisolone/*therapeutic use; Middle Aged; Multiple Sclerosis/*complications/*drug therapy; Parkinsonian Disorders/drug therapy/*etiology; Treatment Outcome
ISSN:
1532-2653 (Electronic); 0967-5868 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorSaidha, Sen_GB
dc.contributor.authorMok, T Hen_GB
dc.contributor.authorButler, Men_GB
dc.contributor.authorFanning, Nen_GB
dc.contributor.authorHarrington, Hen_GB
dc.date.accessioned2012-01-31T16:38:34Z-
dc.date.available2012-01-31T16:38:34Z-
dc.date.issued2012-01-31T16:38:34Z-
dc.identifier.citationJ Clin Neurosci. 2010 May;17(5):654-5. Epub 2010 Mar 9.en_GB
dc.identifier.issn1532-2653 (Electronic)en_GB
dc.identifier.issn0967-5868 (Linking)en_GB
dc.identifier.pmid20219377en_GB
dc.identifier.doi10.1016/j.jocn.2009.09.026en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206350-
dc.description.abstractParkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon beta1a.en_GB
dc.language.isoengen_GB
dc.subject.meshDisease Progressionen_GB
dc.subject.meshGlucocorticoids/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMagnetic Resonance Imagingen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMethylprednisolone/*therapeutic useen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMultiple Sclerosis/*complications/*drug therapyen_GB
dc.subject.meshParkinsonian Disorders/drug therapy/*etiologyen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleMultiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone.en_GB
dc.contributor.departmentDepartment of Neurology, Mercy University Hospital, Grenville Place, Cork,, Ireland. shivsaidha@physicians.ie <shivsaidha@physicians.ie>en_GB
dc.identifier.journalJournal of clinical neuroscience : official journal of the Neurosurgical Society , of Australasiaen_GB
dc.description.provinceMunster-

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