Impaired endothelial nitric oxide bioavailability: a common link between aging, hypertension, and atherogenesis?

Hdl Handle:
http://hdl.handle.net/10147/206309
Title:
Impaired endothelial nitric oxide bioavailability: a common link between aging, hypertension, and atherogenesis?
Authors:
Walsh, Thomas; Donnelly, Teresa; Lyons, Declan
Affiliation:
Department of Medical Gerontology, Mid Western Regional Hospital, University of, Limerick, Dooradoyle, Ireland. thomaswalsh_3@hotmail.com
Citation:
J Am Geriatr Soc. 2009 Jan;57(1):140-5. Epub 2008 Nov 14.
Journal:
Journal of the American Geriatrics Society
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206309
DOI:
10.1111/j.1532-5415.2008.02051.x
PubMed ID:
19054194
Abstract:
Endothelial-derived nitric oxide (NO) is responsible for maintaining continuous vasodilator tone and for regulating local perfusion and systemic blood pressure. It also has significant antiproliferative effects on vascular smooth muscle and platelet anti-aggregatory effects. Impaired endothelial-dependent (NO mediated) vasorelaxation is observed in most animal and human models of healthy aging. It also occurs in age-associated conditions such as atherosclerosis and hypertension. Such "endotheliopathy" increases vascular risk in older adults. Studies have indicated that pharmacotherapeutic intervention with angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methyl-glutaryl coenzyme-A reductase inhibitors may improve NO-mediated vasomotor function. This review, evaluates the association between impaired endothelial NO bioavailability, accelerated vascular aging, and the age-associated conditions hypertension and atherogenesis. This is important, because pharmacotherapy aimed at improving endothelial NO bioavailability could modify age-related vascular disease and transform age into a potentially modifiable vascular risk factor, at least in a subpopulation of older adults.
Language:
eng
MeSH:
Aging/*physiology; Animals; Atherosclerosis/*physiopathology; Biological Availability; Endothelium, Vascular/*physiopathology; Humans; Hypertension/*physiopathology; Nitric Oxide/*physiology
ISSN:
1532-5415 (Electronic); 0002-8614 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Thomasen_GB
dc.contributor.authorDonnelly, Teresaen_GB
dc.contributor.authorLyons, Declanen_GB
dc.date.accessioned2012-01-31T16:47:24Z-
dc.date.available2012-01-31T16:47:24Z-
dc.date.issued2012-01-31T16:47:24Z-
dc.identifier.citationJ Am Geriatr Soc. 2009 Jan;57(1):140-5. Epub 2008 Nov 14.en_GB
dc.identifier.issn1532-5415 (Electronic)en_GB
dc.identifier.issn0002-8614 (Linking)en_GB
dc.identifier.pmid19054194en_GB
dc.identifier.doi10.1111/j.1532-5415.2008.02051.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/206309-
dc.description.abstractEndothelial-derived nitric oxide (NO) is responsible for maintaining continuous vasodilator tone and for regulating local perfusion and systemic blood pressure. It also has significant antiproliferative effects on vascular smooth muscle and platelet anti-aggregatory effects. Impaired endothelial-dependent (NO mediated) vasorelaxation is observed in most animal and human models of healthy aging. It also occurs in age-associated conditions such as atherosclerosis and hypertension. Such "endotheliopathy" increases vascular risk in older adults. Studies have indicated that pharmacotherapeutic intervention with angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methyl-glutaryl coenzyme-A reductase inhibitors may improve NO-mediated vasomotor function. This review, evaluates the association between impaired endothelial NO bioavailability, accelerated vascular aging, and the age-associated conditions hypertension and atherogenesis. This is important, because pharmacotherapy aimed at improving endothelial NO bioavailability could modify age-related vascular disease and transform age into a potentially modifiable vascular risk factor, at least in a subpopulation of older adults.en_GB
dc.language.isoengen_GB
dc.subject.meshAging/*physiologyen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshAtherosclerosis/*physiopathologyen_GB
dc.subject.meshBiological Availabilityen_GB
dc.subject.meshEndothelium, Vascular/*physiopathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypertension/*physiopathologyen_GB
dc.subject.meshNitric Oxide/*physiologyen_GB
dc.titleImpaired endothelial nitric oxide bioavailability: a common link between aging, hypertension, and atherogenesis?en_GB
dc.contributor.departmentDepartment of Medical Gerontology, Mid Western Regional Hospital, University of, Limerick, Dooradoyle, Ireland. thomaswalsh_3@hotmail.comen_GB
dc.identifier.journalJournal of the American Geriatrics Societyen_GB
dc.description.provinceMunster-

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