Can mean platelet component be used as an index of platelet activity in stable coronary artery disease?

Hdl Handle:
http://hdl.handle.net/10147/206300
Title:
Can mean platelet component be used as an index of platelet activity in stable coronary artery disease?
Authors:
Cooke, John; Murphy, Tracy; McFadden, Eugene; O'Reilly, Mairead; Cahill, Mary R
Affiliation:
Mid-Western Regional Hospital, Dooradoyle, Limerick, Ireland.
Citation:
Hematology. 2009 Apr;14(2):111-4.
Journal:
Hematology (Amsterdam, Netherlands)
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206300
DOI:
10.1179/102453309X385160
PubMed ID:
19298724
Abstract:
Acute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.
Language:
eng
MeSH:
Blood Platelets/metabolism/pathology/*physiology; Case-Control Studies; Coronary Angiography; Coronary Artery Disease/*blood; Female; Flow Cytometry/methods; Humans; Male; Middle Aged; P-Selectin/pharmacology; Platelet Activation/*physiology; Platelet Count/methods; Prospective Studies
ISSN:
1607-8454 (Electronic); 1024-5332 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCooke, Johnen_GB
dc.contributor.authorMurphy, Tracyen_GB
dc.contributor.authorMcFadden, Eugeneen_GB
dc.contributor.authorO'Reilly, Maireaden_GB
dc.contributor.authorCahill, Mary Ren_GB
dc.date.accessioned2012-01-31T16:46:25Z-
dc.date.available2012-01-31T16:46:25Z-
dc.date.issued2012-01-31T16:46:25Z-
dc.identifier.citationHematology. 2009 Apr;14(2):111-4.en_GB
dc.identifier.issn1607-8454 (Electronic)en_GB
dc.identifier.issn1024-5332 (Linking)en_GB
dc.identifier.pmid19298724en_GB
dc.identifier.doi10.1179/102453309X385160en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206300-
dc.description.abstractAcute coronary syndrome is associated with intracoronary thrombosis secondary to platelet activation. Previous groups have investigated platelet activation in both stable and unstable vascular disease. Most measures of platelet activation are not routinely available or easily adaptable to large scale clinical use. Recently, measurement of the mean platelet component (MPC) has become part of the routine data provided by an automated full blood count analyser, the Advia 120. MPC measures platelet density which changes on platelet activation. Our objectives were to determine if platelet activation, as measured by MPC, is increased in patients with stable coronary artery disease (CAD) and to determine if MPC could be useful in differentiating people with stable CAD from controls on an everyday clinical basis. Three hundred and forty-five consecutive patients attending for elective coronary angiography had full blood count analysis and MPC measurement performed using an ADVIA-120 analyser. Three hundred and twenty-four were analysed in our final dataset. Two hundred and fifty-three (78%) had CAD. Patients with CAD were significantly (p<0.001) older than those without (63.8 versus 56.0 years). Results failed to demonstrate a difference (p=0.467) in MPC between patients with CAD and those with normal coronary arteries (25.8 versus 26.0). Likewise, there was no correlation between MPC and the severity of CAD (Kendall's tau b=-0.086, p=0.04). MPC is not a useful index of platelet activity in stable CAD when used in everyday clinical practice.en_GB
dc.language.isoengen_GB
dc.subject.meshBlood Platelets/metabolism/pathology/*physiologyen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCoronary Angiographyen_GB
dc.subject.meshCoronary Artery Disease/*blooden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFlow Cytometry/methodsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshP-Selectin/pharmacologyen_GB
dc.subject.meshPlatelet Activation/*physiologyen_GB
dc.subject.meshPlatelet Count/methodsen_GB
dc.subject.meshProspective Studiesen_GB
dc.titleCan mean platelet component be used as an index of platelet activity in stable coronary artery disease?en_GB
dc.contributor.departmentMid-Western Regional Hospital, Dooradoyle, Limerick, Ireland.en_GB
dc.identifier.journalHematology (Amsterdam, Netherlands)en_GB
dc.description.provinceMunster-

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