Secondary recurrent miscarriage is associated with previous male birth.

Hdl Handle:
http://hdl.handle.net/10147/206257
Title:
Secondary recurrent miscarriage is associated with previous male birth.
Authors:
Ooi, Poh Veh; Russell, Noirin; O'Donoghue, Keelin
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
Citation:
J Reprod Immunol. 2011 Jan;88(1):38-41. Epub 2010 Dec 3.
Journal:
Journal of reproductive immunology
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206257
DOI:
10.1016/j.jri.2010.10.004
PubMed ID:
21129780
Abstract:
Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13/32 vs. 6/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.
Language:
eng
MeSH:
Abortion, Habitual/*etiology/immunology; Cohort Studies; Female; HLA Antigens/immunology; Humans; Live Birth; Male; Parturition; Pregnancy; Pregnancy Complications/etiology; Pregnancy Outcome; Reproductive History; Retrospective Studies; Risk Factors; Sex Factors
ISSN:
1872-7603 (Electronic); 0165-0378 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorOoi, Poh Vehen_GB
dc.contributor.authorRussell, Noirinen_GB
dc.contributor.authorO'Donoghue, Keelinen_GB
dc.date.accessioned2012-01-31T16:43:17Z-
dc.date.available2012-01-31T16:43:17Z-
dc.date.issued2012-01-31T16:43:17Z-
dc.identifier.citationJ Reprod Immunol. 2011 Jan;88(1):38-41. Epub 2010 Dec 3.en_GB
dc.identifier.issn1872-7603 (Electronic)en_GB
dc.identifier.issn0165-0378 (Linking)en_GB
dc.identifier.pmid21129780en_GB
dc.identifier.doi10.1016/j.jri.2010.10.004en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206257-
dc.description.abstractSecondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13/32 vs. 6/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.en_GB
dc.language.isoengen_GB
dc.subject.meshAbortion, Habitual/*etiology/immunologyen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHLA Antigens/immunologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLive Birthen_GB
dc.subject.meshMaleen_GB
dc.subject.meshParturitionen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Complications/etiologyen_GB
dc.subject.meshPregnancy Outcomeen_GB
dc.subject.meshReproductive Historyen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSex Factorsen_GB
dc.titleSecondary recurrent miscarriage is associated with previous male birth.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.en_GB
dc.identifier.journalJournal of reproductive immunologyen_GB
dc.description.provinceMunster-

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