Animal models of preeclampsia; uses and limitations.

Hdl Handle:
http://hdl.handle.net/10147/206251
Title:
Animal models of preeclampsia; uses and limitations.
Authors:
McCarthy, F P; Kingdom, J C; Kenny, L C; Walsh, S K
Affiliation:
Anu Research Centre, Department of Obstetrics & Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland., fergusmccarthy@gmail.com
Citation:
Placenta. 2011 Jun;32(6):413-9. Epub 2011 Apr 17.
Journal:
Placenta
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206251
DOI:
10.1016/j.placenta.2011.03.010
PubMed ID:
21497901
Abstract:
Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality and has an unknown etiology. The limited progress made regarding new treatments to reduce the incidence and severity of preeclampsia has been attributed to the difficulties faced in the development of suitable animal models for the mechanistic research of this disease. In addition, animal models need hypotheses on which to be based and the slow development of testable hypotheses has also contributed to this poor progress. The past decade has seen significant advances in our understanding of preeclampsia and the development of viable reproducible animal models has contributed significantly to these advances. Although many of these models have features of preeclampsia, they are still poor overall models of the human disease and limited due to lack of reproducibility and because they do not include the complete spectrum of pathophysiological changes associated with preeclampsia. This review aims to provide a succinct and comprehensive assessment of current animal models of preeclampsia, their uses and limitations with particular attention paid to the best validated and most comprehensive models, in addition to those models which have been utilized to investigate potential therapeutic interventions for the treatment or prevention of preeclampsia.
Language:
eng
MeSH:
Animals; *Disease Models, Animal; Female; Humans; *Pre-Eclampsia; Pregnancy
ISSN:
1532-3102 (Electronic); 0143-4004 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcCarthy, F Pen_GB
dc.contributor.authorKingdom, J Cen_GB
dc.contributor.authorKenny, L Cen_GB
dc.contributor.authorWalsh, S Ken_GB
dc.date.accessioned2012-01-31T16:42:35Z-
dc.date.available2012-01-31T16:42:35Z-
dc.date.issued2012-01-31T16:42:35Z-
dc.identifier.citationPlacenta. 2011 Jun;32(6):413-9. Epub 2011 Apr 17.en_GB
dc.identifier.issn1532-3102 (Electronic)en_GB
dc.identifier.issn0143-4004 (Linking)en_GB
dc.identifier.pmid21497901en_GB
dc.identifier.doi10.1016/j.placenta.2011.03.010en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206251-
dc.description.abstractPreeclampsia remains a leading cause of maternal and fetal morbidity and mortality and has an unknown etiology. The limited progress made regarding new treatments to reduce the incidence and severity of preeclampsia has been attributed to the difficulties faced in the development of suitable animal models for the mechanistic research of this disease. In addition, animal models need hypotheses on which to be based and the slow development of testable hypotheses has also contributed to this poor progress. The past decade has seen significant advances in our understanding of preeclampsia and the development of viable reproducible animal models has contributed significantly to these advances. Although many of these models have features of preeclampsia, they are still poor overall models of the human disease and limited due to lack of reproducibility and because they do not include the complete spectrum of pathophysiological changes associated with preeclampsia. This review aims to provide a succinct and comprehensive assessment of current animal models of preeclampsia, their uses and limitations with particular attention paid to the best validated and most comprehensive models, in addition to those models which have been utilized to investigate potential therapeutic interventions for the treatment or prevention of preeclampsia.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.mesh*Disease Models, Animalen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Pre-Eclampsiaen_GB
dc.subject.meshPregnancyen_GB
dc.titleAnimal models of preeclampsia; uses and limitations.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics & Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland., fergusmccarthy@gmail.comen_GB
dc.identifier.journalPlacentaen_GB
dc.description.provinceMunster-

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