Hdl Handle:
http://hdl.handle.net/10147/206250
Title:
Hemostasis in pre-eclampsia.
Authors:
Ismail, Siti Khadijah; Higgins, John R
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Ireland. k.ismail@ucc.ie
Citation:
Semin Thromb Hemost. 2011 Mar;37(2):111-7. Epub 2011 Mar 2.
Journal:
Seminars in thrombosis and hemostasis
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206250
DOI:
10.1055/s-0030-1270336
PubMed ID:
21370210
Abstract:
Pre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.
Language:
eng
MeSH:
Aspirin/therapeutic use; Female; Hemostasis/*physiology; Heparin, Low-Molecular-Weight/therapeutic use; Humans; Hypertension, Pregnancy-Induced/drug therapy/prevention & control; Placental Circulation; Placentation; Pre-Eclampsia/*blood/etiology; Pregnancy; Thrombophilia/complications/drug therapy
ISSN:
1098-9064 (Electronic); 0094-6176 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorIsmail, Siti Khadijahen_GB
dc.contributor.authorHiggins, John Ren_GB
dc.date.accessioned2012-01-31T16:43:27Z-
dc.date.available2012-01-31T16:43:27Z-
dc.date.issued2012-01-31T16:43:27Z-
dc.identifier.citationSemin Thromb Hemost. 2011 Mar;37(2):111-7. Epub 2011 Mar 2.en_GB
dc.identifier.issn1098-9064 (Electronic)en_GB
dc.identifier.issn0094-6176 (Linking)en_GB
dc.identifier.pmid21370210en_GB
dc.identifier.doi10.1055/s-0030-1270336en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206250-
dc.description.abstractPre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.en_GB
dc.language.isoengen_GB
dc.subject.meshAspirin/therapeutic useen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHemostasis/*physiologyen_GB
dc.subject.meshHeparin, Low-Molecular-Weight/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypertension, Pregnancy-Induced/drug therapy/prevention & controlen_GB
dc.subject.meshPlacental Circulationen_GB
dc.subject.meshPlacentationen_GB
dc.subject.meshPre-Eclampsia/*blood/etiologyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshThrombophilia/complications/drug therapyen_GB
dc.titleHemostasis in pre-eclampsia.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Ireland. k.ismail@ucc.ieen_GB
dc.identifier.journalSeminars in thrombosis and hemostasisen_GB
dc.description.provinceMunster-

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