Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity.

2.50
Hdl Handle:
http://hdl.handle.net/10147/206247
Title:
Local anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity.
Authors:
Dempsey, Eugene; McCreery, Kathryn
Affiliation:
Neonatology, Cork University Maternity Hospital, Cork, Ireland.
Citation:
Cochrane Database Syst Rev. 2011 Sep 7;9:CD007645.
Journal:
Cochrane database of systematic reviews (Online)
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206247
DOI:
10.1002/14651858.CD007645.pub2
PubMed ID:
21901708
Abstract:
BACKGROUND: Screening examinations for retinopathy of prematurity (ROP) are performed routinely in the neonatal intensive care unit and are a recognised cause of pain in the newborn. OBJECTIVES: To determine the effect of instillation of topical anaesthetic eye drops compared with placebo or no treatment on pain in infants undergoing ROP screening. SEARCH STRATEGY: We used the standard search strategy of the Cochrane Neonatal Review Group. This included a search of the Cochrane Neonatal Group register and the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 10, 2010). We identified relevant studies by searching the following: (1) computerised bibliographic databases: MEDLINE (1966 to October 2010), EMBASE (1988 to October 2010) and Web of Science (1975 to March 2010; (2) the Oxford Database of Perinatal Trials. We searched electronically abstracts from PAS from 2000 to 2010 and handsearched abstracts from ESPR from 2000 to 2009. SELECTION CRITERIA: All randomised, or quasi-randomised controlled trials, or randomised cross-over trials. DATA COLLECTION AND ANALYSIS: We used the standard methods of the Cochrane Neonatal Review Group. MAIN RESULTS: We identified two studies for inclusion. Both studies were randomised cross-over trials performed in single centres. Both studies used the Premature Infant Pain Profile (PIPP) score as a measure of pain response. Different methods of evaluating PIPP scores are presented including the absolute PIPP score, a PIPP score > 10 or > 12 and an increase in PIPP >/= 4 from the baseline value. There is a nonsignificant reduction in pain scores at one minute and a nonsignificant increase at five minutes post insertion of the speculum. PIPP score > 12 at one minute resulted in a statistically significant reduction in the number of patients who experienced pain (typical risk ratio (RR) 0.56, 95% CI 0.36 to 0.89; typical risk difference (RD) -0.23, 95% CI -0.39 to -0.86; number needed to treat to benefit (NNTB) 4). When pain was defined as an increase in PIPP > 4 there was a statistically significant reduction in the absolute number of patients who experienced pain at one minute (typical RR 0.70, 95% CI 0.52 to 0.94; typical RD -0.19, 95% CI -0.34 to -0.04; NNTB 5.3). AUTHORS' CONCLUSIONS: The administration of topical proparacaine 30 seconds prior to the ophthalmological evaluation was associated with a reduction in pain scores especially at the time of speculum insertion. However, despite treatment, screening remains a painful procedure and the role of nonpharmacological and pharmacological intervention including different local anaesthetic agents should be ascertained in future randomised trials.
Language:
eng
MeSH:
Anesthetics, Local/*administration & dosage; Eye Pain/*prevention & control; Humans; Infant, Extremely Low Birth Weight; Infant, Newborn; Infant, Premature; Ophthalmic Solutions; Ophthalmoscopy/*adverse effects; Pain Measurement/methods; Propoxycaine/administration & dosage; Retinopathy of Prematurity/*diagnosis
ISSN:
1469-493X (Electronic); 1361-6137 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDempsey, Eugeneen_GB
dc.contributor.authorMcCreery, Kathrynen_GB
dc.date.accessioned2012-01-31T16:44:08Z-
dc.date.available2012-01-31T16:44:08Z-
dc.date.issued2012-01-31T16:44:08Z-
dc.identifier.citationCochrane Database Syst Rev. 2011 Sep 7;9:CD007645.en_GB
dc.identifier.issn1469-493X (Electronic)en_GB
dc.identifier.issn1361-6137 (Linking)en_GB
dc.identifier.pmid21901708en_GB
dc.identifier.doi10.1002/14651858.CD007645.pub2en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206247-
dc.description.abstractBACKGROUND: Screening examinations for retinopathy of prematurity (ROP) are performed routinely in the neonatal intensive care unit and are a recognised cause of pain in the newborn. OBJECTIVES: To determine the effect of instillation of topical anaesthetic eye drops compared with placebo or no treatment on pain in infants undergoing ROP screening. SEARCH STRATEGY: We used the standard search strategy of the Cochrane Neonatal Review Group. This included a search of the Cochrane Neonatal Group register and the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library, Issue 10, 2010). We identified relevant studies by searching the following: (1) computerised bibliographic databases: MEDLINE (1966 to October 2010), EMBASE (1988 to October 2010) and Web of Science (1975 to March 2010; (2) the Oxford Database of Perinatal Trials. We searched electronically abstracts from PAS from 2000 to 2010 and handsearched abstracts from ESPR from 2000 to 2009. SELECTION CRITERIA: All randomised, or quasi-randomised controlled trials, or randomised cross-over trials. DATA COLLECTION AND ANALYSIS: We used the standard methods of the Cochrane Neonatal Review Group. MAIN RESULTS: We identified two studies for inclusion. Both studies were randomised cross-over trials performed in single centres. Both studies used the Premature Infant Pain Profile (PIPP) score as a measure of pain response. Different methods of evaluating PIPP scores are presented including the absolute PIPP score, a PIPP score > 10 or > 12 and an increase in PIPP >/= 4 from the baseline value. There is a nonsignificant reduction in pain scores at one minute and a nonsignificant increase at five minutes post insertion of the speculum. PIPP score > 12 at one minute resulted in a statistically significant reduction in the number of patients who experienced pain (typical risk ratio (RR) 0.56, 95% CI 0.36 to 0.89; typical risk difference (RD) -0.23, 95% CI -0.39 to -0.86; number needed to treat to benefit (NNTB) 4). When pain was defined as an increase in PIPP > 4 there was a statistically significant reduction in the absolute number of patients who experienced pain at one minute (typical RR 0.70, 95% CI 0.52 to 0.94; typical RD -0.19, 95% CI -0.34 to -0.04; NNTB 5.3). AUTHORS' CONCLUSIONS: The administration of topical proparacaine 30 seconds prior to the ophthalmological evaluation was associated with a reduction in pain scores especially at the time of speculum insertion. However, despite treatment, screening remains a painful procedure and the role of nonpharmacological and pharmacological intervention including different local anaesthetic agents should be ascertained in future randomised trials.en_GB
dc.language.isoengen_GB
dc.subject.meshAnesthetics, Local/*administration & dosageen_GB
dc.subject.meshEye Pain/*prevention & controlen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Extremely Low Birth Weighten_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshInfant, Prematureen_GB
dc.subject.meshOphthalmic Solutionsen_GB
dc.subject.meshOphthalmoscopy/*adverse effectsen_GB
dc.subject.meshPain Measurement/methodsen_GB
dc.subject.meshPropoxycaine/administration & dosageen_GB
dc.subject.meshRetinopathy of Prematurity/*diagnosisen_GB
dc.titleLocal anaesthetic eye drops for prevention of pain in preterm infants undergoing screening for retinopathy of prematurity.en_GB
dc.contributor.departmentNeonatology, Cork University Maternity Hospital, Cork, Ireland.en_GB
dc.identifier.journalCochrane database of systematic reviews (Online)en_GB
dc.description.provinceMunster-

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