The impact of maternal celiac disease on birthweight and preterm birth: a Danish population-based cohort study.

Hdl Handle:
http://hdl.handle.net/10147/206230
Title:
The impact of maternal celiac disease on birthweight and preterm birth: a Danish population-based cohort study.
Authors:
Khashan, A S; Henriksen, T B; Mortensen, P B; McNamee, R; McCarthy, F P; Pedersen, M G; Kenny, L C
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynecology, University College , Cork, Cork University Maternity Hospital, Cork, Ireland. a.khashan@ucc.ie
Citation:
Hum Reprod. 2010 Feb;25(2):528-34. Epub 2009 Nov 24.
Journal:
Human reproduction (Oxford, England)
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206230
DOI:
10.1093/humrep/dep409
PubMed ID:
19939833
Abstract:
BACKGROUND: Adverse pregnancy outcomes have been associated with maternal celiac disease (CD). In this study, we investigate the effect of treated and untreated maternal CD on infant birthweight and preterm birth. METHODS: A population-based cohort study consisted of all singleton live births in Denmark between 1 January 1979 and 31 December 2004 was used. A total of 1,504,342 babies were born to 836,241 mothers during the study period. Of those, 1105 babies were born to women with diagnosed CD and 346 were born to women with undiagnosed CD. Women with diagnosed CD were considered as treated with a gluten free diet while women with undiagnosed CD were considered as untreated. The outcome measures were: birthweight, small for gestational age (SGA: birthweight <10th centile), very small for gestational age (VSGA: birthweight <5th centile) and preterm birth. We compared these measures in treated and untreated women with those of a reference group (no history of CD). RESULTS: Women with untreated CD delivered smaller babies [difference = -98 g (95% CI: -130, -67)], with a higher risk of SGA infants [OR = 1.31 (95% CI: 1.06, 1.63)], VSGA infants [OR = 1.54 (95% CI: 1.17, 2.03)] and preterm birth [OR = 1.33 (95% CI: 1.02, 1.72)] compared with women without CD. Women with treated CD had no increased risk of reduced mean birthweight, risk of delivering SGA and VSGA infants or preterm birth compared with women without CD. CONCLUSION: Untreated maternal CD increases the risk of reduced birthweight, the risk of delivering SGA and VSGA infants and preterm birth. Diagnosis and presumed treatment of maternal CD with a gluten-free diet appeared to result in a birthweight and preterm birth rate similar to those in women without CD.
Language:
eng
MeSH:
Adult; *Birth Weight; Celiac Disease/diet therapy/*epidemiology; Cohort Studies; Denmark/epidemiology; Female; Humans; Infant, Newborn; *Infant, Premature; *Infant, Small for Gestational Age; *Infant, Very Low Birth Weight; Male; Pregnancy; *Pregnancy Complications; *Pregnancy Outcome
ISSN:
1460-2350 (Electronic); 0268-1161 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKhashan, A Sen_GB
dc.contributor.authorHenriksen, T Ben_GB
dc.contributor.authorMortensen, P Ben_GB
dc.contributor.authorMcNamee, Ren_GB
dc.contributor.authorMcCarthy, F Pen_GB
dc.contributor.authorPedersen, M Gen_GB
dc.contributor.authorKenny, L Cen_GB
dc.date.accessioned2012-01-31T16:42:16Z-
dc.date.available2012-01-31T16:42:16Z-
dc.date.issued2012-01-31T16:42:16Z-
dc.identifier.citationHum Reprod. 2010 Feb;25(2):528-34. Epub 2009 Nov 24.en_GB
dc.identifier.issn1460-2350 (Electronic)en_GB
dc.identifier.issn0268-1161 (Linking)en_GB
dc.identifier.pmid19939833en_GB
dc.identifier.doi10.1093/humrep/dep409en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206230-
dc.description.abstractBACKGROUND: Adverse pregnancy outcomes have been associated with maternal celiac disease (CD). In this study, we investigate the effect of treated and untreated maternal CD on infant birthweight and preterm birth. METHODS: A population-based cohort study consisted of all singleton live births in Denmark between 1 January 1979 and 31 December 2004 was used. A total of 1,504,342 babies were born to 836,241 mothers during the study period. Of those, 1105 babies were born to women with diagnosed CD and 346 were born to women with undiagnosed CD. Women with diagnosed CD were considered as treated with a gluten free diet while women with undiagnosed CD were considered as untreated. The outcome measures were: birthweight, small for gestational age (SGA: birthweight <10th centile), very small for gestational age (VSGA: birthweight <5th centile) and preterm birth. We compared these measures in treated and untreated women with those of a reference group (no history of CD). RESULTS: Women with untreated CD delivered smaller babies [difference = -98 g (95% CI: -130, -67)], with a higher risk of SGA infants [OR = 1.31 (95% CI: 1.06, 1.63)], VSGA infants [OR = 1.54 (95% CI: 1.17, 2.03)] and preterm birth [OR = 1.33 (95% CI: 1.02, 1.72)] compared with women without CD. Women with treated CD had no increased risk of reduced mean birthweight, risk of delivering SGA and VSGA infants or preterm birth compared with women without CD. CONCLUSION: Untreated maternal CD increases the risk of reduced birthweight, the risk of delivering SGA and VSGA infants and preterm birth. Diagnosis and presumed treatment of maternal CD with a gluten-free diet appeared to result in a birthweight and preterm birth rate similar to those in women without CD.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.mesh*Birth Weighten_GB
dc.subject.meshCeliac Disease/diet therapy/*epidemiologyen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshDenmark/epidemiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.mesh*Infant, Prematureen_GB
dc.subject.mesh*Infant, Small for Gestational Ageen_GB
dc.subject.mesh*Infant, Very Low Birth Weighten_GB
dc.subject.meshMaleen_GB
dc.subject.meshPregnancyen_GB
dc.subject.mesh*Pregnancy Complicationsen_GB
dc.subject.mesh*Pregnancy Outcomeen_GB
dc.titleThe impact of maternal celiac disease on birthweight and preterm birth: a Danish population-based cohort study.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynecology, University College , Cork, Cork University Maternity Hospital, Cork, Ireland. a.khashan@ucc.ieen_GB
dc.identifier.journalHuman reproduction (Oxford, England)en_GB
dc.description.provinceMunster-

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