Antenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant.

Hdl Handle:
http://hdl.handle.net/10147/206229
Title:
Antenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant.
Authors:
McCarthy, Fergus P; Giles, Michelle L; Rowlands, Shelley; Purcell, Kara J; Jones, Cheryl A
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
Citation:
Cochrane Database Syst Rev. 2011 Mar 16;(3):CD008371.
Journal:
Cochrane database of systematic reviews (Online)
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206229
DOI:
10.1002/14651858.CD008371.pub2
PubMed ID:
21412919
Abstract:
BACKGROUND: Cytomegalovirus (CMV) is a herpesvirus and the most common cause of congenital infection in developed countries. Congenital CMV infection can have devastating consequences to the fetus. The high incidence and the serious morbidity associated with congenital CMV infection emphasise the need for effective interventions to prevent the antenatal transmission of CMV infection. OBJECTIVES: The aim of this review was to assess the benefits and harms of interventions used during pregnancy to prevent mother to fetus transmission of CMV infection. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010). SELECTION CRITERIA: All randomised controlled trials (RCTs) and quasi RCTs investigating antenatal interventions for preventing the transmission of CMV from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion. MAIN RESULTS: We identified six studies from the search. None of these studies met the pre-defined criteria for inclusion in this review. AUTHORS' CONCLUSIONS: To date, no RCTs are available that examine antenatal interventions for preventing the transmission of CMV from the infected mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. Further research is needed to assess the efficacy of interventions aimed at preventing the transmission of CMV from the mother to fetus during pregnancy including a long-term follow-up of exposed infants and a cost effective analysis.
Language:
eng
MeSH:
Cytomegalovirus Infections/congenital/*transmission; Female; Fetal Diseases/*prevention & control; Humans; Infectious Disease Transmission, Vertical/*prevention & control; Pregnancy; Pregnancy Complications, Infectious/*virology; Prenatal Care
ISSN:
1469-493X (Electronic); 1361-6137 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcCarthy, Fergus Pen_GB
dc.contributor.authorGiles, Michelle Len_GB
dc.contributor.authorRowlands, Shelleyen_GB
dc.contributor.authorPurcell, Kara Jen_GB
dc.contributor.authorJones, Cheryl Aen_GB
dc.date.accessioned2012-01-31T16:43:22Z-
dc.date.available2012-01-31T16:43:22Z-
dc.date.issued2012-01-31T16:43:22Z-
dc.identifier.citationCochrane Database Syst Rev. 2011 Mar 16;(3):CD008371.en_GB
dc.identifier.issn1469-493X (Electronic)en_GB
dc.identifier.issn1361-6137 (Linking)en_GB
dc.identifier.pmid21412919en_GB
dc.identifier.doi10.1002/14651858.CD008371.pub2en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206229-
dc.description.abstractBACKGROUND: Cytomegalovirus (CMV) is a herpesvirus and the most common cause of congenital infection in developed countries. Congenital CMV infection can have devastating consequences to the fetus. The high incidence and the serious morbidity associated with congenital CMV infection emphasise the need for effective interventions to prevent the antenatal transmission of CMV infection. OBJECTIVES: The aim of this review was to assess the benefits and harms of interventions used during pregnancy to prevent mother to fetus transmission of CMV infection. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010). SELECTION CRITERIA: All randomised controlled trials (RCTs) and quasi RCTs investigating antenatal interventions for preventing the transmission of CMV from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion. MAIN RESULTS: We identified six studies from the search. None of these studies met the pre-defined criteria for inclusion in this review. AUTHORS' CONCLUSIONS: To date, no RCTs are available that examine antenatal interventions for preventing the transmission of CMV from the infected mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. Further research is needed to assess the efficacy of interventions aimed at preventing the transmission of CMV from the mother to fetus during pregnancy including a long-term follow-up of exposed infants and a cost effective analysis.en_GB
dc.language.isoengen_GB
dc.subject.meshCytomegalovirus Infections/congenital/*transmissionen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFetal Diseases/*prevention & controlen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfectious Disease Transmission, Vertical/*prevention & controlen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Complications, Infectious/*virologyen_GB
dc.subject.meshPrenatal Careen_GB
dc.titleAntenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.en_GB
dc.identifier.journalCochrane database of systematic reviews (Online)en_GB
dc.description.provinceMunster-

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