Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.

Hdl Handle:
http://hdl.handle.net/10147/206223
Title:
Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.
Authors:
Nadeem, Montasser; Murray, Deirdre M; Boylan, Geraldine B; Dempsey, Eugene M; Ryan, Cornelius A
Affiliation:
Neonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.
Citation:
BMC Pediatr. 2011 Feb 4;11:10.
Journal:
BMC pediatrics
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206223
DOI:
10.1186/1471-2431-11-10
PubMed ID:
21294901
Abstract:
BACKGROUND: To examine the blood glucose profile and the relationship between blood glucose levels and neurodevelopmental outcome in term infants with hypoxic-ischaemic encephalopathy. METHODS: Blood glucose values within 72 hours of birth were collected from 52 term infants with hypoxic-ischaemic encephalopathy. Hypoglycaemia [< 46.8 mg/dL (2.6 mmol/L)] and hyperglycaemia [> 150 mg/dL (8.3 mmol/L)] were correlated to neurodevelopmental outcome at 24 months of age. RESULTS: Four fifths of the 468 blood samples were in the normoglycaemic range (392/468:83.8%). Of the remaining 76 samples, 51.3% were in the hypoglycaemic range and (48.7%) were hyperglycaemic. A quarter of the hypoglycaemic samples (28.2%:11/39) and a third of the hyperglycaemic samples (32.4%:12/37) were recorded within the first 30 minutes of life. Mean (SD) blood glucose values did not differ between infants with normal and abnormal outcomes [4.89(2.28) mmol/L and 5.02(2.35) mmol/L, p value = 0.15] respectively. In term infants with hypoxic-ischaemic encephalopathy, early hypoglycaemia (between 0-6 hours of life) was associated with adverse outcome at 24 months of age [OR = 5.8, CI = 1.04-32)]. On multivariate analysis to adjust for grade of HIE this association was not statistically significant. Late hypoglycaemia (6-72 hours of life) was not associated with abnormal outcome [OR = 0.22, CI (0.04-1.14)]. The occurrence of hyperglycaemia was not associated with adverse outcome. CONCLUSION: During the first 72 hours of life, blood glucose profile in infants with hypoxic-ischaemic encephalopathy varies widely despite a management protocol. Early hypoglycaemia (0-6 hours of life) was associated with severe HIE, and thereby; adverse outcome.
Language:
eng
MeSH:
Asphyxia Neonatorum/*blood/complications; Biological Markers; Birth Weight; Blood Glucose/*analysis; Brain Damage, Chronic/*epidemiology/etiology; Female; Follow-Up Studies; Gestational Age; Humans; Hyperglycemia/congenital/epidemiology; Hypoglycemia/complications/congenital/*epidemiology; Hypothermia, Induced; Hypoxia-Ischemia, Brain/*blood/complications/therapy; Infant, Newborn; Male; Retrospective Studies; Time Factors; Treatment Outcome
ISSN:
1471-2431 (Electronic); 1471-2431 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorNadeem, Montasseren_GB
dc.contributor.authorMurray, Deirdre Men_GB
dc.contributor.authorBoylan, Geraldine Ben_GB
dc.contributor.authorDempsey, Eugene Men_GB
dc.contributor.authorRyan, Cornelius Aen_GB
dc.date.accessioned2012-01-31T16:43:15Z-
dc.date.available2012-01-31T16:43:15Z-
dc.date.issued2012-01-31T16:43:15Z-
dc.identifier.citationBMC Pediatr. 2011 Feb 4;11:10.en_GB
dc.identifier.issn1471-2431 (Electronic)en_GB
dc.identifier.issn1471-2431 (Linking)en_GB
dc.identifier.pmid21294901en_GB
dc.identifier.doi10.1186/1471-2431-11-10en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206223-
dc.description.abstractBACKGROUND: To examine the blood glucose profile and the relationship between blood glucose levels and neurodevelopmental outcome in term infants with hypoxic-ischaemic encephalopathy. METHODS: Blood glucose values within 72 hours of birth were collected from 52 term infants with hypoxic-ischaemic encephalopathy. Hypoglycaemia [< 46.8 mg/dL (2.6 mmol/L)] and hyperglycaemia [> 150 mg/dL (8.3 mmol/L)] were correlated to neurodevelopmental outcome at 24 months of age. RESULTS: Four fifths of the 468 blood samples were in the normoglycaemic range (392/468:83.8%). Of the remaining 76 samples, 51.3% were in the hypoglycaemic range and (48.7%) were hyperglycaemic. A quarter of the hypoglycaemic samples (28.2%:11/39) and a third of the hyperglycaemic samples (32.4%:12/37) were recorded within the first 30 minutes of life. Mean (SD) blood glucose values did not differ between infants with normal and abnormal outcomes [4.89(2.28) mmol/L and 5.02(2.35) mmol/L, p value = 0.15] respectively. In term infants with hypoxic-ischaemic encephalopathy, early hypoglycaemia (between 0-6 hours of life) was associated with adverse outcome at 24 months of age [OR = 5.8, CI = 1.04-32)]. On multivariate analysis to adjust for grade of HIE this association was not statistically significant. Late hypoglycaemia (6-72 hours of life) was not associated with abnormal outcome [OR = 0.22, CI (0.04-1.14)]. The occurrence of hyperglycaemia was not associated with adverse outcome. CONCLUSION: During the first 72 hours of life, blood glucose profile in infants with hypoxic-ischaemic encephalopathy varies widely despite a management protocol. Early hypoglycaemia (0-6 hours of life) was associated with severe HIE, and thereby; adverse outcome.en_GB
dc.language.isoengen_GB
dc.subject.meshAsphyxia Neonatorum/*blood/complicationsen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshBirth Weighten_GB
dc.subject.meshBlood Glucose/*analysisen_GB
dc.subject.meshBrain Damage, Chronic/*epidemiology/etiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFollow-Up Studiesen_GB
dc.subject.meshGestational Ageen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHyperglycemia/congenital/epidemiologyen_GB
dc.subject.meshHypoglycemia/complications/congenital/*epidemiologyen_GB
dc.subject.meshHypothermia, Induceden_GB
dc.subject.meshHypoxia-Ischemia, Brain/*blood/complications/therapyen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshMaleen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleEarly blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.en_GB
dc.contributor.departmentNeonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.en_GB
dc.identifier.journalBMC pediatricsen_GB
dc.description.provinceMunster-

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