Risk of affective disorders following prenatal exposure to severe life events: a Danish population-based cohort study.

Hdl Handle:
http://hdl.handle.net/10147/206222
Title:
Risk of affective disorders following prenatal exposure to severe life events: a Danish population-based cohort study.
Authors:
Khashan, Ali S; McNamee, Roseanne; Henriksen, Tine B; Pedersen, Marianne G; Kenny, Louise C; Abel, Kathryn M; Mortensen, Preben B
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynecology, University College , Cork, Cork University Maternity Hospital, Cork, Ireland. a.khashan@ucc.ie
Citation:
J Psychiatr Res. 2011 Jul;45(7):879-85. Epub 2011 Jan 3.
Journal:
Journal of psychiatric research
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206222
DOI:
10.1016/j.jpsychires.2010.12.005
PubMed ID:
21208629
Abstract:
OBJECTIVE: To examine the effect of prenatal exposure to severe life events on risk of affective disorders in the offspring. METHODS: In a cohort of 1.1 million Danish births from May 1978 until December 1997, mothers were considered exposed if one (or more) of their close relatives died or was diagnosed with serious illness up to 6 months before conception or during pregnancy. Offspring were followed up from their 10th birthday until their death, migration, onset of affective disorder or 31 December 2007; hospital admissions were identified by linkage to the Central Psychiatric Register. Log-linear Poisson regression was used for data analysis. RESULTS: The risk of affective disorders was increased in male offspring whose mothers were exposed to severe life events during the second trimester (adjusted RR 1.55 [95% CI 1.05-2.28]). There was an increased risk of male offspring affective disorders in relation to maternal exposure to death of a relative in the second trimester (adjusted RR 1.74 [95% CI 1.06-2.84]) or serious illness in a relative before pregnancy (adjusted RR 1.44 [95% CI 1.02-2.05]). There was no evidence for an association between prenatal exposure to severe life events and risk of female offspring affective disorders. CONCLUSIONS: Our population-based study suggests that prenatal maternal exposure to severe life events may increase the risk of affective disorders in male offspring. These findings are consistent with studies of populations exposed to famine and earthquake disasters which indicate that prenatal environment may influence the neurodevelopment of the unborn child.
Language:
eng
MeSH:
Adolescent; Adult; Aged; Child; Cohort Studies; Cross-Sectional Studies; Denmark; Female; Gestational Age; Humans; Infant, Newborn; *Life Change Events; Male; Middle Aged; Mood Disorders/*epidemiology/*psychology; Pregnancy; Prenatal Exposure Delayed Effects/*psychology; Risk Factors; Sex Factors; Young Adult
ISSN:
1879-1379 (Electronic); 0022-3956 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKhashan, Ali Sen_GB
dc.contributor.authorMcNamee, Roseanneen_GB
dc.contributor.authorHenriksen, Tine Ben_GB
dc.contributor.authorPedersen, Marianne Gen_GB
dc.contributor.authorKenny, Louise Cen_GB
dc.contributor.authorAbel, Kathryn Men_GB
dc.contributor.authorMortensen, Preben Ben_GB
dc.date.accessioned2012-01-31T16:43:12Z-
dc.date.available2012-01-31T16:43:12Z-
dc.date.issued2012-01-31T16:43:12Z-
dc.identifier.citationJ Psychiatr Res. 2011 Jul;45(7):879-85. Epub 2011 Jan 3.en_GB
dc.identifier.issn1879-1379 (Electronic)en_GB
dc.identifier.issn0022-3956 (Linking)en_GB
dc.identifier.pmid21208629en_GB
dc.identifier.doi10.1016/j.jpsychires.2010.12.005en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206222-
dc.description.abstractOBJECTIVE: To examine the effect of prenatal exposure to severe life events on risk of affective disorders in the offspring. METHODS: In a cohort of 1.1 million Danish births from May 1978 until December 1997, mothers were considered exposed if one (or more) of their close relatives died or was diagnosed with serious illness up to 6 months before conception or during pregnancy. Offspring were followed up from their 10th birthday until their death, migration, onset of affective disorder or 31 December 2007; hospital admissions were identified by linkage to the Central Psychiatric Register. Log-linear Poisson regression was used for data analysis. RESULTS: The risk of affective disorders was increased in male offspring whose mothers were exposed to severe life events during the second trimester (adjusted RR 1.55 [95% CI 1.05-2.28]). There was an increased risk of male offspring affective disorders in relation to maternal exposure to death of a relative in the second trimester (adjusted RR 1.74 [95% CI 1.06-2.84]) or serious illness in a relative before pregnancy (adjusted RR 1.44 [95% CI 1.02-2.05]). There was no evidence for an association between prenatal exposure to severe life events and risk of female offspring affective disorders. CONCLUSIONS: Our population-based study suggests that prenatal maternal exposure to severe life events may increase the risk of affective disorders in male offspring. These findings are consistent with studies of populations exposed to famine and earthquake disasters which indicate that prenatal environment may influence the neurodevelopment of the unborn child.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshChilden_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshCross-Sectional Studiesen_GB
dc.subject.meshDenmarken_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGestational Ageen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.mesh*Life Change Eventsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMood Disorders/*epidemiology/*psychologyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPrenatal Exposure Delayed Effects/*psychologyen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSex Factorsen_GB
dc.subject.meshYoung Adulten_GB
dc.titleRisk of affective disorders following prenatal exposure to severe life events: a Danish population-based cohort study.en_GB
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynecology, University College , Cork, Cork University Maternity Hospital, Cork, Ireland. a.khashan@ucc.ieen_GB
dc.identifier.journalJournal of psychiatric researchen_GB
dc.description.provinceMunster-

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