A prospective cohort study investigating associations between hyperemesis gravidarum and cognitive, behavioural and emotional well-being in pregnancy.

2.50
Hdl Handle:
http://hdl.handle.net/10147/206218
Title:
A prospective cohort study investigating associations between hyperemesis gravidarum and cognitive, behavioural and emotional well-being in pregnancy.
Authors:
McCarthy, Fergus P; Khashan, Ali S; North, Robyn A; Moss-Morris, Rona; Baker, Philip N; Dekker, Gus; Poston, Lucilla; Kenny, Louise C
Affiliation:
Department of Obstetrics and Gynecology, The Anu Research Centre, Cork University, Maternity Hospital, University College Cork, Cork, Ireland., Fergus.mccarthy@ucc.ie
Citation:
PLoS One. 2011;6(11):e27678. Epub 2011 Nov 18.
Journal:
PloS one
Issue Date:
31-Jan-2012
URI:
http://hdl.handle.net/10147/206218
DOI:
10.1371/journal.pone.0027678
PubMed ID:
22125621
Abstract:
OBJECTIVES: To investigate the association between hyperemesis gravidarum and altered cognitive, behavioural and emotional well-being in pregnancy. METHODS: The study cohort consisted of 3423 nulliparous women recruited in the Screening for Pregnancy Endpoints (SCOPE) study performed in Auckland, New Zealand; Adelaide, Australia; Cork, Ireland; Manchester and London, United Kingdom between November 2004 and August 2008. Women were interviewed at 15+/-1 weeks' gestation and at 20+/-1weeks' gestation. Women with a diagnosis of hyperemesis gravidarum (HG) were compared with women who did not have a diagnosis of HG. Main outcome measures included the Short form State- Trait Anxiety Inventory (STAI) score (range 6-24), Perceived Stress Scale score (PSS, range 0-30), Edinburgh Postnatal Depression Scale (EPDS) score (range 0-30 or categories a-c) and behavioural responses to pregnancy score (limiting/resting [range 0-20] and all-or-nothing [range 0-28]). RESULTS: During the study period 164 women suffered from HG prior to their 15 week interview. Women with HG had significantly higher mean STAI, PSS, EPDS and limiting response to pregnancy scores compared to women without HG. These differences were observed at both 15+/-1 and 20+/-1 weeks' of gestation. The magnitude of these differences was greater in women with severe HG compared to all women with HG. Women with severe HG had an increased risk of having a spontaneous preterm birth compared with women without HG (adjusted OR 2.6 [95% C.I. 1.2, 5.7]). CONCLUSION: This is the first large prospective study on women with HG. Women with HG, particularly severe HG, are at increased risk of cognitive, behavioural and emotional dysfunction in pregnancy. Women with severe HG had a higher rate of spontaneous preterm birth compared to women without HG. Further research is required to determine whether the provision of emotional support for women with HG is beneficial.
Language:
eng
ISSN:
1932-6203 (Electronic); 1932-6203 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcCarthy, Fergus Pen_GB
dc.contributor.authorKhashan, Ali Sen_GB
dc.contributor.authorNorth, Robyn Aen_GB
dc.contributor.authorMoss-Morris, Ronaen_GB
dc.contributor.authorBaker, Philip Nen_GB
dc.contributor.authorDekker, Gusen_GB
dc.contributor.authorPoston, Lucillaen_GB
dc.contributor.authorKenny, Louise Cen_GB
dc.date.accessioned2012-01-31T16:44:06Z-
dc.date.available2012-01-31T16:44:06Z-
dc.date.issued2012-01-31T16:44:06Z-
dc.identifier.citationPLoS One. 2011;6(11):e27678. Epub 2011 Nov 18.en_GB
dc.identifier.issn1932-6203 (Electronic)en_GB
dc.identifier.issn1932-6203 (Linking)en_GB
dc.identifier.pmid22125621en_GB
dc.identifier.doi10.1371/journal.pone.0027678en_GB
dc.identifier.urihttp://hdl.handle.net/10147/206218-
dc.description.abstractOBJECTIVES: To investigate the association between hyperemesis gravidarum and altered cognitive, behavioural and emotional well-being in pregnancy. METHODS: The study cohort consisted of 3423 nulliparous women recruited in the Screening for Pregnancy Endpoints (SCOPE) study performed in Auckland, New Zealand; Adelaide, Australia; Cork, Ireland; Manchester and London, United Kingdom between November 2004 and August 2008. Women were interviewed at 15+/-1 weeks' gestation and at 20+/-1weeks' gestation. Women with a diagnosis of hyperemesis gravidarum (HG) were compared with women who did not have a diagnosis of HG. Main outcome measures included the Short form State- Trait Anxiety Inventory (STAI) score (range 6-24), Perceived Stress Scale score (PSS, range 0-30), Edinburgh Postnatal Depression Scale (EPDS) score (range 0-30 or categories a-c) and behavioural responses to pregnancy score (limiting/resting [range 0-20] and all-or-nothing [range 0-28]). RESULTS: During the study period 164 women suffered from HG prior to their 15 week interview. Women with HG had significantly higher mean STAI, PSS, EPDS and limiting response to pregnancy scores compared to women without HG. These differences were observed at both 15+/-1 and 20+/-1 weeks' of gestation. The magnitude of these differences was greater in women with severe HG compared to all women with HG. Women with severe HG had an increased risk of having a spontaneous preterm birth compared with women without HG (adjusted OR 2.6 [95% C.I. 1.2, 5.7]). CONCLUSION: This is the first large prospective study on women with HG. Women with HG, particularly severe HG, are at increased risk of cognitive, behavioural and emotional dysfunction in pregnancy. Women with severe HG had a higher rate of spontaneous preterm birth compared to women without HG. Further research is required to determine whether the provision of emotional support for women with HG is beneficial.en_GB
dc.language.isoengen_GB
dc.titleA prospective cohort study investigating associations between hyperemesis gravidarum and cognitive, behavioural and emotional well-being in pregnancy.en_GB
dc.contributor.departmentDepartment of Obstetrics and Gynecology, The Anu Research Centre, Cork University, Maternity Hospital, University College Cork, Cork, Ireland., Fergus.mccarthy@ucc.ieen_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceMunster-

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