Survival trends of US dialysis patients with heart failure: 1995 to 2005.
Affiliation
Regional Kidney Centre, Department of Medicine, Letterkenny General Hospital,, Letterkenny, Donegal, Ireland. Austin.Stack@hse.ieIssue Date
2012-01-31T16:31:12ZMeSH
AdolescentAdult
Age Factors
Aged
Analysis of Variance
Chi-Square Distribution
Cohort Studies
Female
Heart Failure/*mortality
Humans
Kidney Failure, Chronic/*mortality/*therapy
Logistic Models
Male
Middle Aged
Odds Ratio
Prevalence
Proportional Hazards Models
Renal Dialysis/*mortality
Risk Assessment
Risk Factors
Sex Factors
Survival Analysis
Survival Rate
Time Factors
Treatment Outcome
United States/epidemiology
Young Adult
Metadata
Show full item recordCitation
Clin J Am Soc Nephrol. 2011 Aug;6(8):1982-9. Epub 2011 Jul 22.Journal
Clinical journal of the American Society of Nephrology : CJASNDOI
10.2215/CJN.01130211PubMed ID
21784821Abstract
BACKGROUND AND OBJECTIVES: Congestive heart failure (CHF) is a major risk factor for death in end-stage kidney disease; however, data on prevalence and survival trends are limited. The objective of this study was to determine the prevalence and mortality effect of CHF in successive incident dialysis cohorts. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was a population-based cohort of incident US dialysis patients (n = 926,298) from 1995 to 2005. Age- and gender-specific prevalence of CHF was determined by incident year, whereas temporal trends in mortality were compared using multivariable Cox regression. RESULTS: The prevalence of CHF was significantly higher in women than men and in older than younger patients, but it did not change over time in men (range 28% to 33%) or women (range 33% to 36%). From 1995 to 2005, incident death rates decreased for younger men (70 years). For women, the pattern was similar but less impressive. During this period, the adjusted mortality risks (relative risk [RR]) from CHF decreased in men (from RR = 1.06 95% Confidence intervals (CI) 1.02-1.11 in 1995 to 0.91 95% CI 0.87-0.96 in 2005) and women (from RR = 1.06 95% CI 1.01-1.10 in 1995 to 0.90 95% CI 0.85-0.95 in 2005 compared with referent year 2000; RR = 1.00). The reduction in mortality over time was greater for younger than older patients (20% to 30% versus 5% to 10% decrease per decade). CONCLUSIONS: Although CHF remains a common condition at dialysis initiation, mortality risks in US patients have declined from 1995 to 2005.Language
engISSN
1555-905X (Electronic)1555-9041 (Linking)
ae974a485f413a2113503eed53cd6c53
10.2215/CJN.01130211
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