Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population.

Hdl Handle:
http://hdl.handle.net/10147/203754
Title:
Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population.
Authors:
Welsh, Paul; Murray, Heather M; Buckley, Brendan M; de Craen, Anton J M; Ford, Ian; Jukema, J Wouter; Macfarlane, Peter W; Packard, Chris J; Stott, David J; Westendorp, Rudi G J; Shepherd, James; Sattar, Naveed
Affiliation:
Faculty of Medicine, University of Glasgow, Scotland, UK. p.welsh@clinmed.gla.ac.uk
Citation:
Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. 2009, 32 (2):308-10 Diabetes Care
Journal:
Diabetes care
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10147/203754
DOI:
10.2337/dc08-1458
PubMed ID:
19001191
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628699/pdf/308.pdf
Abstract:
To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women.; We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up.; In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]).; Leptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.
Item Type:
Article
Language:
en
Description:
OBJECTIVE: To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women. RESEARCH DESIGN AND METHODS: We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up. RESULTS: In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]). CONCLUSIONS: Leptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.
MeSH:
Aged; Aged, 80 and over; Biological Markers; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Ireland; Leptin; Male; Myocardial Infarction; Netherlands; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Scotland; Stroke
ISSN:
1935-5548

Full metadata record

DC FieldValue Language
dc.contributor.authorWelsh, Paulen
dc.contributor.authorMurray, Heather Men
dc.contributor.authorBuckley, Brendan Men
dc.contributor.authorde Craen, Anton J Men
dc.contributor.authorFord, Ianen
dc.contributor.authorJukema, J Wouteren
dc.contributor.authorMacfarlane, Peter Wen
dc.contributor.authorPackard, Chris Jen
dc.contributor.authorStott, David Jen
dc.contributor.authorWestendorp, Rudi G Jen
dc.contributor.authorShepherd, Jamesen
dc.contributor.authorSattar, Naveeden
dc.date.accessioned2012-01-19T16:49:06Z-
dc.date.available2012-01-19T16:49:06Z-
dc.date.issued2009-02-
dc.identifier.citationLeptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. 2009, 32 (2):308-10 Diabetes Careen
dc.identifier.issn1935-5548-
dc.identifier.pmid19001191-
dc.identifier.doi10.2337/dc08-1458-
dc.identifier.urihttp://hdl.handle.net/10147/203754-
dc.descriptionOBJECTIVE: To clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women. RESEARCH DESIGN AND METHODS: We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up. RESULTS: In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]). CONCLUSIONS: Leptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.en
dc.description.abstractTo clarify the association of circulating levels of leptin with risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women.-
dc.description.abstractWe related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up.-
dc.description.abstractIn treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women (1.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]).-
dc.description.abstractLeptin, similar to other markers of adiposity in general, is more strongly related to risk of diabetes than CVD in the elderly.-
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628699/pdf/308.pdfen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBiological Markers-
dc.subject.meshCardiovascular Diseases-
dc.subject.meshDiabetes Mellitus-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshLeptin-
dc.subject.meshMale-
dc.subject.meshMyocardial Infarction-
dc.subject.meshNetherlands-
dc.subject.meshProportional Hazards Models-
dc.subject.meshProspective Studies-
dc.subject.meshRisk Assessment-
dc.subject.meshRisk Factors-
dc.subject.meshScotland-
dc.subject.meshStroke-
dc.titleLeptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population.en
dc.typeArticleen
dc.contributor.departmentFaculty of Medicine, University of Glasgow, Scotland, UK. p.welsh@clinmed.gla.ac.uken
dc.identifier.journalDiabetes careen
dc.description.provinceMunster-

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